KEGG   PATHWAY: psec00260
Entry
psec00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas sp. CCOS 191
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psec00260  Glycine, serine and threonine metabolism
psec00260

Module
psec_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psec00260]
psec_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psec00260]
psec_M00555  Betaine biosynthesis, choline => betaine [PATH:psec00260]
psec_M00621  Glycine cleavage system [PATH:psec00260]
psec_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:psec00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas sp. CCOS 191 [GN:psec]
Gene
CCOS191_1442  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
CCOS191_1561  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CCOS191_1089  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CCOS191_0078  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
CCOS191_1090  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
CCOS191_5006  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CCOS191_5005  glyA1; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
CCOS191_4643  glyA2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
CCOS191_4539  hprA; Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
CCOS191_0886  ghrB1; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CCOS191_2228  glxK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
CCOS191_3721  ttuD; putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
CCOS191_0430  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
CCOS191_0263  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CCOS191_3882  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
CCOS191_0577  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
CCOS191_4059  glycine acetyltransferase [KO:K00639] [EC:2.3.1.29]
CCOS191_3025  amine oxidase [KO:K00274] [EC:1.4.3.4]
CCOS191_3034  amine oxidase [KO:K00274] [EC:1.4.3.4]
CCOS191_3230  amine oxidase [KO:K00274] [EC:1.4.3.4]
CCOS191_3239  amine oxidase [KO:K00274] [EC:1.4.3.4]
CCOS191_2646  amine oxidase, flavin-containing [KO:K00274] [EC:1.4.3.4]
CCOS191_0507  amine oxidase [KO:K00274] [EC:1.4.3.4]
CCOS191_0218  gcvP2; Glycine dehydrogenase [decarboxylating] 2 [KO:K00281] [EC:1.4.4.2]
CCOS191_1000  gcvP1; Glycine dehydrogenase [decarboxylating] 1 [KO:K00281] [EC:1.4.4.2]
CCOS191_0216  gcvT1; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
CCOS191_0998  gcvT2; Aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
CCOS191_5262  lpd3; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
CCOS191_1449  lpdV; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CCOS191_1619  lpdG; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CCOS191_0217  gcvH2; Glycine cleavage system H protein 2 [KO:K02437]
CCOS191_1001  gcvH1; Glycine cleavage system H protein 1 [KO:K02437]
CCOS191_0731  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CCOS191_0423  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CCOS191_4601  Betaine aldehyde dehydrogenase, chloroplastic [KO:K00130] [EC:1.2.1.8]
CCOS191_0424  betB; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CCOS191_5012  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
CCOS191_5011  ferredoxin [KO:K21832] [EC:1.14.13.251]
CCOS191_5017  stcD; putative N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
CCOS191_5016  (Fe-S)-binding protein [KO:K21834]
CCOS191_5015  electron transfer flavoprotein subunit alpha [KO:K25960]
CCOS191_5014  electron transfer flavoprotein subunit beta [KO:K25961]
CCOS191_5002  soxA; Sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
CCOS191_5004  soxB; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
CCOS191_5001  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
CCOS191_5003  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
CCOS191_3987  metC; Cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
CCOS191_4038  Cystathionine beta-lyase or cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
CCOS191_2831  sdaA3; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
CCOS191_0999  sdaA2; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
CCOS191_0330  sdaA1; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
CCOS191_2858  ilvA2; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
CCOS191_3940  hypothetical protein [KO:K01754] [EC:4.3.1.19]
CCOS191_0269  ilvA1; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
CCOS191_3134  Sdsl; Serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CCOS191_0038  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
CCOS191_0039  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
CCOS191_2906  ectB; Diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CCOS191_3659  rhbA; Diaminobutyrate-2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psec00010  Glycolysis / Gluconeogenesis
psec00020  Citrate cycle (TCA cycle)
psec00230  Purine metabolism
psec00250  Alanine, aspartate and glutamate metabolism
psec00270  Cysteine and methionine metabolism
psec00290  Valine, leucine and isoleucine biosynthesis
psec00300  Lysine biosynthesis
psec00330  Arginine and proline metabolism
psec00460  Cyanoamino acid metabolism
psec00470  D-Amino acid metabolism
psec00564  Glycerophospholipid metabolism
psec00620  Pyruvate metabolism
psec00630  Glyoxylate and dicarboxylate metabolism
psec00640  Propanoate metabolism
psec00680  Methane metabolism
psec00860  Porphyrin metabolism
psec00920  Sulfur metabolism
KO pathway
ko00260   
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