KEGG   PATHWAY: psim02024
Entry
psim02024                   Pathway                                
Name
Quorum sensing - Pimelobacter simplex
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
psim02024  Quorum sensing
psim02024

Other DBs
GO: 0009372
Organism
Pimelobacter simplex [GN:psim]
Gene
KR76_01370  Anthranilate synthase [KO:K01658] [EC:4.1.3.27]
KR76_11205  phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
KR76_01360  2-Amino-2-deoxy-isochorismate synthase [KO:K13063] [EC:2.6.1.86]
KR76_23670  sensor histidine kinase [KO:K07667]
KR76_16010  Agmatine/putrescine antiporter, associated with agmatine catabolism [KO:K20265]
KR76_26855  ABC transporter, periplasmic spermidine putrescine-binding protein PotD [KO:K02055]
KR76_17690  Spermidine/putrescine-binding periplasmic protein [KO:K02055]
KR76_26845  Spermidine Putrescine ABC transporter permease component potC [KO:K02053]
KR76_17680  Spermidine Putrescine ABC transporter permease component potC [KO:K02053]
KR76_17685  Spermidine Putrescine ABC transporter permease component PotB [KO:K02054]
KR76_26850  Spermidine Putrescine ABC transporter permease component PotB [KO:K02054]
KR76_26860  Putrescine transport ATP-binding protein PotA [KO:K02052]
KR76_17675  Putrescine transport ATP-binding protein PotA [KO:K02052]
KR76_11595  Branched-chain amino acid ABC transporter, amino acid-binding protein [KO:K01999]
KR76_00735  Branched-chain amino acid ABC transporter, amino acid-binding protein [KO:K01999]
KR76_25025  ABC amino acid transporter, substrate-binding component CamA [KO:K01999]
KR76_25195  ABC amino acid transporter, substrate-binding component CamA [KO:K01999]
KR76_23220  branched-chain amino acid ABC transporter [KO:K01999]
KR76_19630  Branched-chain amino acid ABC transporter, amino acid-binding protein [KO:K01999]
KR76_00470  hypothetical protein [KO:K01999]
KR76_00460  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
KR76_11600  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
KR76_00750  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
KR76_24660  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
KR76_25190  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
KR76_19635  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
KR76_08780  High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997 K01998]
KR76_24655  Branched-chain amino acid transport system permease protein LivM [KO:K01998]
KR76_11605  Branched-chain amino acid transport system permease protein LivM [KO:K01998]
KR76_00450  Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
KR76_11610  Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
KR76_19645  Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
KR76_00455  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_00745  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_08790  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_11615  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_19650  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_24670  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_25180  Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
KR76_17560  beta-lactamase-like protein [KO:K13075] [EC:3.1.1.81]
KR76_09985  Fibronectin, type III domain protein [KO:K20276]
KR76_21160  hypothetical protein [KO:K20276]
KR76_23475  transmembrane serine/threonine-protein kinase D PknD [KO:K20276]
KR76_25240  internalin, putative [KO:K20276]
KR76_03625  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
KR76_00905  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
KR76_11075  Long-chain fatty-acid-CoA ligase, Mycobacterial subgroup FadD15 [KO:K01897] [EC:6.2.1.3]
KR76_17545  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
KR76_23425  Acetoacetyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
KR76_11785  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
KR76_09810  Fatty-acid-CoA ligase FadD7 [KO:K01897] [EC:6.2.1.3]
KR76_05675  Fatty-acid-CoA ligase FadD7 [KO:K01897] [EC:6.2.1.3]
KR76_03075  cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase [KO:K10914]
KR76_26255  GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
KR76_12650  hypothetical protein [KO:K20333]
KR76_12360  Diaminohydroxyphosphoribosylaminopyrimidine deaminase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
KR76_20305  Putative inner membrane protein [KO:K09936]
KR76_00940  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_13155  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_14790  ABC transport protein BldKB [KO:K02035]
KR76_09625  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_09410  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_17985  Dipeptide-binding ABC transporter, periplasmic substrate-binding component [KO:K02035]
KR76_25285  putative ABC transporter, periplasmic solute-binding protein [KO:K02035]
KR76_25590  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_25655  Dipeptide-binding ABC transporter, periplasmic substrate-binding component [KO:K02035]
KR76_26510  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_20940  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K02035]
KR76_00920  Putative glutathione transporter, permease component [KO:K02033]
KR76_13165  ABC transporter permease protein [KO:K02033]
KR76_14785  ABC transporter permease protein [KO:K02033]
KR76_09615  Oligopeptide transport system permease protein OppB [KO:K02033]
KR76_09415  Dipeptide transport system permease protein DppB [KO:K02033]
KR76_18015  Putative glutathione transporter, permease component [KO:K02033]
KR76_25300  Dipeptide transport system permease protein DppB [KO:K02033]
KR76_25585  Dipeptide transport system permease protein DppB [KO:K02033]
KR76_25650  Dipeptide transport system permease protein DppB [KO:K02033]
KR76_26515  Dipeptide transport system permease protein DppB [KO:K02033]
KR76_13160  oligopeptide transport integral membrane protein [KO:K02034]
KR76_14795  oligopeptide transport integral membrane protein [KO:K02034]
KR76_18010  Dipeptide transport system permease protein DppC [KO:K02034]
KR76_25295  putative ABC transporter, permease [KO:K02034]
KR76_25645  Dipeptide transport system permease protein DppC [KO:K02034]
KR76_26520  Dipeptide transport system permease protein DppC [KO:K02034]
KR76_25580  Oligopeptide transport system permease protein OppB [KO:K02031 K02034]
KR76_09620  Oligopeptide transport system permease protein OppC [KO:K02034]
KR76_00930  oligopeptide ABC transporter ATP-binding protein [KO:K02031]
KR76_13170  Oligopeptide transport ATP-binding protein OppD [KO:K02031]
KR76_14780  oligopeptide ABC transporter ATP-binding protein [KO:K02031]
KR76_09610  Oligopeptide transport ATP-binding protein OppF [KO:K02031 K02032]
KR76_18005  Oligopeptide transport system permease protein OppB [KO:K02031]
KR76_25640  Oligopeptide transport system permease protein OppB [KO:K02031]
KR76_26525  Dipeptide transport ATP-binding protein DppD [KO:K02031 K02032]
KR76_18000  Oligopeptide transport ATP-binding protein OppF [KO:K02032]
KR76_14775  Oligopeptide transport ATP-binding protein OppF [KO:K02032]
KR76_00855  Inner membrane protein translocase component YidC, long form [KO:K03217]
KR76_04490  Preprotein translocase subunit SecE [KO:K03073]
KR76_14055  Preprotein translocase subunit SecG [KO:K03075]
KR76_21185  Preprotein translocase secY subunit [KO:K03076]
KR76_14840  Preprotein translocase subunit YajC [KO:K03210]
KR76_08650  Protein export cytoplasm protein SecA ATPase RNA helicase [KO:K03070] [EC:7.4.2.8]
KR76_18320  Signal recognition particle receptor protein FtsY (alpha subunit) [KO:K03110]
KR76_18275  Signal recognition particle, subunit Ffh SRP54 [KO:K03106] [EC:3.6.5.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
  Authors
Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  Journal
Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
  Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  Title
Quinolones: from antibiotics to autoinducers.
  Journal
FEMS Microbiol Rev 35:247-74 (2011)
DOI:10.1111/j.1574-6976.2010.00247.x
Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
DOI:10.1111/j.1365-2958.2009.06906.x
Reference
PMID:7665477
  Authors
Beck von Bodman S, Farrand SK
  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
  Journal
J Bacteriol 177:5000-8 (1995)
DOI:10.1128/JB.177.17.5000-5008.1995
Reference
PMID:19761612
  Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
DOI:10.1186/1471-2164-10-441
Reference
PMID:16041013
  Authors
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  Journal
Infect Immun 73:4982-92 (2005)
DOI:10.1128/IAI.73.8.4982-4992.2005
Reference
PMID:22949660
  Authors
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
  Title
Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
  Journal
Proc Natl Acad Sci U S A 109:15479-84 (2012)
DOI:10.1073/pnas.1205037109
Reference
PMID:23799665
  Authors
Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
  Title
Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
  Journal
Virulence 4:400-9 (2013)
DOI:10.4161/viru.25338
Reference
PMID:21166386
  Authors
Deng Y, Wu J, Tao F, Zhang LH
  Title
Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
  Journal
Chem Rev 111:160-73 (2011)
DOI:10.1021/cr100354f
Reference
PMID:21227698
  Authors
Ryan RP, Dow JM
  Title
Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
  Journal
Trends Microbiol 19:145-52 (2011)
DOI:10.1016/j.tim.2010.12.003
Reference
PMID:15522077
  Authors
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
  Title
Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
  Journal
Mol Microbiol 54:921-34 (2004)
DOI:10.1111/j.1365-2958.2004.04338.x
Reference
PMID:17376080
  Authors
Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
  Title
Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
  Journal
Mol Microbiol 64:165-79 (2007)
DOI:10.1111/j.1365-2958.2007.05646.x
Reference
PMID:21622734
  Authors
Stauff DL, Bassler BL
  Title
Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
  Journal
J Bacteriol 193:3871-8 (2011)
DOI:10.1128/JB.05125-11
Reference
PMID:21504831
  Authors
Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
  Title
A strategy for antagonizing quorum sensing.
  Journal
Mol Cell 42:199-209 (2011)
DOI:10.1016/j.molcel.2011.04.003
Reference
PMID:16513747
  Authors
Hao G, Burr TJ
  Title
Regulation of long-chain N-acyl-homoserine lactones in Agrobacterium vitis.
  Journal
J Bacteriol 188:2173-83 (2006)
DOI:10.1128/JB.188.6.2173-2183.2006
Reference
PMID:20514483
  Authors
Savka MA, Le PT, Burr TJ
  Title
LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
  Journal
Curr Microbiol 62:101-10 (2011)
DOI:10.1007/s00284-010-9679-1
Reference
PMID:26579084
  Authors
Le KY, Otto M
  Title
Quorum-sensing regulation in staphylococci-an overview.
  Journal
Front Microbiol 6:1174 (2015)
DOI:10.3389/fmicb.2015.01174
Reference
PMID:18851841
  Authors
Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M
  Title
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
  Journal
Mol Cell 32:150-8 (2008)
DOI:10.1016/j.molcel.2008.08.005
Reference
PMID:25714717
  Authors
Darkoh C, DuPont HL, Norris SJ, Kaplan HB
  Title
Toxin synthesis by Clostridium difficile is regulated through quorum signaling.
  Journal
MBio 6:e02569 (2015)
DOI:10.1128/mBio.02569-14
Reference
PMID:25824838
  Authors
Vidal JE, Shak JR, Canizalez-Roman A
  Title
The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.
  Journal
Infect Immun 83:2430-42 (2015)
DOI:10.1128/IAI.00240-15
Reference
PMID:19363118
  Authors
Ohtani K, Yuan Y, Hassan S, Wang R, Wang Y, Shimizu T
  Title
Virulence gene regulation by the agr system in Clostridium perfringens.
  Journal
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Related
pathway
psim00405  Phenazine biosynthesis
psim02040  Flagellar assembly
KO pathway
ko02024   
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