KEGG   PATHWAY: ptep04150
Entry
ptep04150                   Pathway                                
Name
mTOR signaling pathway - Parasteatoda tepidariorum (common house spider)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ptep04150  mTOR signaling pathway
ptep04150

Organism
Parasteatoda tepidariorum (common house spider) [GN:ptep]
Gene
107443310  large neutral amino acids transporter small subunit 2-like [KO:K13780]
107452476  Y+L amino acid transporter 2 isoform X1 [KO:K13780]
107444086  Y+L amino acid transporter 2 [KO:K13780]
107451245  sodium-coupled neutral amino acid transporter 9 homolog [KO:K14995]
107456819  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
107443915  V-type proton ATPase subunit B [KO:K02147]
107445108  V-type proton ATPase subunit C [KO:K02148]
122270774  V-type proton ATPase subunit D 1-like [KO:K02149]
107457323  V-type proton ATPase subunit D-like [KO:K02149]
107451387  V-type proton ATPase subunit D [KO:K02149]
107446071  V-type proton ATPase subunit D [KO:K02149]
107440117  V-type proton ATPase subunit E [KO:K02150]
107453529  V-type proton ATPase subunit F [KO:K02151]
107454597  V-type proton ATPase subunit G [KO:K02152]
107447575  V-type proton ATPase subunit G [KO:K02152]
107451994  V-type proton ATPase subunit H-like [KO:K02144]
107452824  V-type proton ATPase subunit H isoform X1 [KO:K02144]
107444644  ragulator complex protein LAMTOR1 [KO:K20397]
107453543  uncharacterized protein LOC107453543 isoform X1 [KO:K20397]
107438657  ragulator complex protein LAMTOR2-B [KO:K20398]
107449995  ragulator complex protein LAMTOR4 [KO:K20399]
107456763  folliculin [KO:K09594]
107456072  folliculin-interacting protein 1 isoform X1 [KO:K20401]
107449326  ras-related GTP-binding protein A [KO:K16185]
107436943  ras-related GTP-binding protein C isoform X1 [KO:K16186]
107436978  ras-related GTP-binding protein C [KO:K16186]
107443478  GATOR complex protein MIOS isoform X1 [KO:K20407]
107454401  nucleoporin SEH1 [KO:K14299]
107439884  GATOR complex protein WDR24 isoform X2 [KO:K20408]
107441419  GATOR complex protein WDR59 isoform X1 [KO:K20409]
107451491  protein SEC13 homolog [KO:K14004]
107443174  protein SEC13 homolog isoform X2 [KO:K14004]
107443117  GATOR complex protein Iml1 isoform X1 [KO:K20404]
107439534  GATOR complex protein NPRL2 isoform X1 [KO:K20405]
107449371  GATOR complex protein NPRL3 [KO:K20406]
107453804  S-phase kinase-associated protein 2 [KO:K03875]
107450389  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
107444734  uncharacterized protein LOC107444734 isoform X1 [KO:K16184]
107439010  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107450002  target of rapamycin complex subunit lst8 [KO:K08266]
107441420  telomere length regulation protein TEL2 homolog [KO:K11137]
107444975  TELO2-interacting protein 1 homolog [KO:K20403]
107437215  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
107448508  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
107446432  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
107454465  eukaryotic translation initiation factor 4E [KO:K03259]
107451200  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107439814  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
107447686  40S ribosomal protein S6 [KO:K02991]
107444928  STE20-related kinase adapter protein alpha [KO:K08271]
107448241  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107451572  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107453678  protein Mo25-like [KO:K08272]
107450058  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107448053  hamartin [KO:K07206]
107447247  TBC1 domain family member 7 isoform X1 [KO:K20396]
107455436  GTP-binding protein Rheb homolog [KO:K07208]
107438386  protein Wnt-1 [KO:K03209]
107442876  protein Wnt-2b-A-like [KO:K00182]
107444171  protein Wnt-4-like [KO:K00408]
107447180  protein Wnt-5b-like [KO:K00444]
107445649  protein Wnt-1 [KO:K00444]
107438387  protein Wnt-6 isoform X1 [KO:K00445]
107442309  protein Wnt-7b-like [KO:K00572]
107447185  protein Wnt-7b-like precursor [KO:K00572]
107453612  protein Wnt-8b-like [KO:K00714]
107446521  protein Wnt-11b-2 [KO:K01384]
107449252  protein Wnt-11 isoform X1 [KO:K01384]
107457243  protein Wnt-16-like precursor [KO:K01558]
107451398  frizzled-7-B [KO:K02432]
107441380  frizzled-4 [KO:K02354]
107442148  frizzled-4 [KO:K02354]
107451394  frizzled-5 [KO:K02375]
107456922  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
107441379  glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
107443254  glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
107440477  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K07209] [EC:2.7.11.10]
107444576  uncharacterized protein LOC107444576 [KO:K04526]
107448965  insulin-2-like [KO:K04526]
107448973  bombyxin A-1 homolog [KO:K04526]
107455901  insulin-like [KO:K04526]
107451234  bombyxin B-1 homolog [KO:K04526]
107455739  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107450481  growth factor receptor-bound protein 2 [KO:K04364]
107446993  son of sevenless homolog 2 isoform X1 [KO:K03099]
107448797  GTPase HRas [KO:K07827]
107445892  serine/threonine-protein kinase A-Raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107443359  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107441316  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107442143  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
107456412  ribosomal protein S6 kinase 2 beta isoform X2 [KO:K04373] [EC:2.7.11.1]
107453084  ribosomal protein S6 kinase 2 beta isoform X1 [KO:K04373] [EC:2.7.11.1]
107438950  insulin receptor substrate 1 [KO:K16172]
107446916  insulin receptor substrate 1-B [KO:K16172]
107439742  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107441029  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107437416  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107454170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107437787  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107438749  3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
107451835  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107442776  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
107452496  rapamycin-insensitive companion of mTOR [KO:K08267]
107449634  proline-rich protein 5-like isoform X1 [KO:K20411]
107453752  ras-like GTP-binding protein RHO [KO:K04513]
107442249  ras-like GTP-binding protein RHO [KO:K04513]
107452056  ras-like GTP-binding protein Rho1 [KO:K04513]
107445195  protein kinase C, brain isozyme-like [KO:K02677] [EC:2.7.11.13]
107449617  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ptep00561  Glycerolipid metabolism
ptep04140  Autophagy - animal
KO pathway
ko04150   
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