KEGG   PATHWAY: ptr03440
Entry
ptr03440                    Pathway                                
Name
Homologous recombination - Pan troglodytes (chimpanzee)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ptr03440  Homologous recombination
ptr03440

Other DBs
GO: 0000724
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
741448  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X2 [KO:K03111]
107974853  RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
737902  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
464278  NBN; nibrin isoform X1 [KO:K10867]
451530  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
449497  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
470638  BARD1; BRCA1-associated RING domain protein 1 isoform X2 [KO:K10683]
455333  RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
454796  BRIP1; Fanconi anemia group J protein isoform X2 [KO:K15362] [EC:5.6.2.3]
460709  TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X2 [KO:K10728]
461205  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
462299  UIMC1; BRCA1-A complex subunit RAP80 [KO:K20775]
455827  BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 [KO:K20776]
459112  BABAM2; BRISC and BRCA1-A complex member 2 isoform X2 [KO:K12173]
465951  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2 [KO:K11864] [EC:3.4.19.-]
453988  PALB2; partner and localizer of BRCA2 isoform X2 [KO:K10897]
452526  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
747549  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
452174  SYCP3; synaptonemal complex protein 3 isoform X2 [KO:K19528]
454414  RPA1; replication protein A 70 kDa DNA-binding subunit isoform X2 [KO:K07466]
456680  RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit [KO:K10739]
472290  RPA3; replication protein A 14 kDa subunit [KO:K10740]
736976  RPA4; replication protein A 30 kDa subunit [KO:K10741]
453339  RAD51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
466911  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
467487  RAD51B; DNA repair protein RAD51 homolog 2 isoform X3 [KO:K10869]
455162  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
468212  RAD51D; DNA repair protein RAD51 homolog 4 isoform X4 [KO:K10871]
738997  XRCC2; DNA repair protein XRCC2 [KO:K10879]
100611736  XRCC3; DNA repair protein XRCC3 isoform X2 [KO:K10880]
456563  RAD54L; DNA repair and recombination protein RAD54-like isoform X1 [KO:K10875] [EC:5.6.2.-]
472821  RAD54B; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
456228  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
472654  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
451422  POLD3; DNA polymerase delta subunit 3 isoform X2 [KO:K03504]
451366  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
453650  BLM; Bloom syndrome protein isoform X2 [KO:K10901] [EC:5.6.2.4]
458682  TOP3B; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
466667  MUS81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
747125  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

DBGET integrated database retrieval system