KEGG   PATHWAY: rcu00260
Entry
rcu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Ricinus communis (castor bean)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rcu00260  Glycine, serine and threonine metabolism
rcu00260

Module
rcu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rcu00260]
rcu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rcu00260]
rcu_M00555  Betaine biosynthesis, choline => betaine [PATH:rcu00260]
rcu_M00621  Glycine cleavage system [PATH:rcu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ricinus communis (castor bean) [GN:rcu]
Gene
8273113  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
8277163  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
8270673  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
8282718  homoserine kinase [KO:K00872] [EC:2.7.1.39]
8272525  threonine synthase 1, chloroplastic [KO:K01733] [EC:4.2.3.1]
8284687  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
8258622  low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
8262997  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
8260084  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
8284566  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
8286891  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
8270249  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
8280329  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
8286122  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
8273576  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
8272488  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
8258477  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
8258475  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
8263037  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
8267232  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
8283033  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
8271345  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
8288553  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
8288126  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
8264748  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
8268758  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
8284432  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
8278300  copper methylamine oxidase isoform X2 [KO:K00276] [EC:1.4.3.21]
8261471  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
8261466  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
8261470  primary amine oxidase 1 isoform X1 [KO:K00276] [EC:1.4.3.21]
8272134  primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
8272135  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
8273500  copper methylamine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
8261468  LOW QUALITY PROTEIN: primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
8275599  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
8284173  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
8258791  dihydrolipoyl dehydrogenase 1, chloroplastic isoform X2 [KO:K00382] [EC:1.8.1.4]
8261311  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
8284627  glycine cleavage system H protein, mitochondrial [KO:K02437]
8267572  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
8269354  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
8273496  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
8258071  choline monooxygenase, chloroplastic [KO:K00499] [EC:1.14.15.7]
8258123  aminoaldehyde dehydrogenase 2, peroxisomal isoform X1 [KO:K00130] [EC:1.2.1.8]
8259358  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
8272784  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
8274901  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
8266453  serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
8274723  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
8284236  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
8260816  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rcu00010  Glycolysis / Gluconeogenesis
rcu00020  Citrate cycle (TCA cycle)
rcu00230  Purine metabolism
rcu00250  Alanine, aspartate and glutamate metabolism
rcu00270  Cysteine and methionine metabolism
rcu00290  Valine, leucine and isoleucine biosynthesis
rcu00300  Lysine biosynthesis
rcu00330  Arginine and proline metabolism
rcu00460  Cyanoamino acid metabolism
rcu00470  D-Amino acid metabolism
rcu00564  Glycerophospholipid metabolism
rcu00600  Sphingolipid metabolism
rcu00620  Pyruvate metabolism
rcu00630  Glyoxylate and dicarboxylate metabolism
rcu00640  Propanoate metabolism
rcu00860  Porphyrin metabolism
rcu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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