KEGG   PATHWAY: rsl02024
Entry
rsl02024                    Pathway                                
Name
Quorum sensing - Ralstonia solanacearum PSI07
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
rsl02024  Quorum sensing
rsl02024

Other DBs
GO: 0009372
Organism
Ralstonia solanacearum PSI07 [GN:rsl]
Gene
RPSI07_0575  Sensor protein, Histidine kinase [KO:K10916] [EC:2.7.13.3 3.1.3.-]
RPSI07_2157  hfq; RNA chaperone Protein hfq, post-transcriptional regulator [KO:K03666]
RPSI07_0623  trpE; component I of anthranilate synthase [KO:K01657] [EC:4.1.3.27]
RPSI07_0622  trpG; Anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
RPSI07_0160  solI; Acyl-homoserine-lactone synthase, autoinducer synthesis protein solI [KO:K13061] [EC:2.3.1.184]
RPSI07_mp0704  solI; Acyl-homoserine-lactone synthase (Autoinducer synthesis protein solI) [KO:K13061] [EC:2.3.1.184]
RPSI07_2664  putative dtdp-rhamnosyl transferase rfbf protein [KO:K12990] [EC:2.4.1.-]
RPSI07_0856  aroG; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, phenylalanine-repressible) [KO:K01626] [EC:2.5.1.54]
RPSI07_2598  aroG; 3-deoxy-7-phosphoheptulonate synthase [KO:K01626] [EC:2.5.1.54]
RPSI07_mp1403  flhD; DNA-binding transcriptional dual regulator with FlhC [KO:K02403]
RPSI07_mp1402  flhC; Flagellar transcriptional activator flhC; sigma factor, dual regulator with flhD [KO:K02402]
RPSI07_0401  kdpE; response regulator (OmpR family) in two-component regulatory system with KdpD, regulation of potassium translocation [KO:K07667]
RPSI07_p0005  Putative conjugative transfer protein TrbJ [KO:K20266]
RPSI07_p0007  putative conjugative transfer protein TrbL [KO:K07344]
RPSI07_1777  Putative Spermidine/putrescine ABC transpoter (substrate binding protein) (potD) [KO:K02055]
RPSI07_1830  putative ABC transporter [KO:K02055]
RPSI07_1595  ABC transporter, periplasmic substrate-binding protein [KO:K02055]
RPSI07_1775  putative spermidine/putrescine transport system permease (potC) [KO:K02053]
RPSI07_1831  putative ABC transporter, membrane component [KO:K02053]
RPSI07_1832  putative ABC transporter, membrane component [KO:K02053]
RPSI07_1593  putative ABC transporter, permease protein [KO:K02053]
RPSI07_1596  ABC transporter, permease component [KO:K02053]
RPSI07_1776  putative polyamine ABC transporter, permease protein [KO:K02054]
RPSI07_1594  ABC transporter ATP-binding protein [KO:K02052]
RPSI07_1778  potA; Spermidine/putrescine ABC transporter ATP-binding subunit [KO:K02052]
RPSI07_1833  putative ABC transporter, ATP-binding component [KO:K02052]
RPSI07_mp1692  putative leucine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K01999]
RPSI07_0115  putative amino-acid ABC transporter [KO:K01999]
RPSI07_0143  putative ABC-type branched-chain amino acid transport system [KO:K01999]
RPSI07_0102  putative branched-chain amino acid transport system permease, periplasmic component [KO:K01999]
RPSI07_1046  putative branched-chain amino acid ABC transporter, periplasmic component [KO:K01999]
RPSI07_1033  putative leucine transporter subunit; periplasmic-binding component of ABC superfamily (livK) [KO:K01999]
RPSI07_2762  putative branched amino acid transport system permease, periplasmic binding component [KO:K01999]
RPSI07_mp0014  putative Leu/Ile/Val-binding periplasmic (Pbp) abc transporter protein [KO:K01999]
RPSI07_1178  putative substrate-binding periplasmic abc transporter protein [KO:K01999]
RPSI07_3107  putative branched amino acid transport system permease, periplasmic binding component [KO:K01999]
RPSI07_1791  putative ABC-type branched-chain amino acid transporter, periplasmic component [KO:K01999]
RPSI07_1360  putative branched amino acid ABC transporter [KO:K01999]
RPSI07_mp1337  putative Leu/Ile/Val-binding periplasmic (PBP) ABC transporter protein [KO:K01999]
RPSI07_0103  putative Branched-chain amino acid transport system permease, membrane component (livH) [KO:K01997]
RPSI07_1034  livH; leucine/isoleucine/valine transporter subunit; membrane component of ABC superfamily [KO:K01997]
RPSI07_mp0015  livH; high-affinity branched-chain leucine/isoleucine/valine transporter subunit protein (ABC superfamily, membrane) [KO:K01997]
RPSI07_1174  putative transmembrane abc transporter protein [KO:K01997]
RPSI07_1792  putative ABC-type branched-chain amino acid transporter, membrane component (livH) [KO:K01997]
RPSI07_mp0603  ABC transporter; branched-chain amino acid transport protein [KO:K01997]
RPSI07_mp1338  putative ABC-type branched-chain amino acid transport system, permease component. Phosphotransferase system, fructose-specific IIC domain [KO:K01997]
RPSI07_mp0604  ABC transporter, permease protein (N-ter) and ATP-binding protein (C-ter) [KO:K01995 K01998]
RPSI07_0104  putative Branched-chain amino acid transport system permease, membrane component (livM) [KO:K01998]
RPSI07_1035  livM; leucine/isoleucine/valine transporter subunit; Inner-membrane translocator, membrane component of ABC superfamily [KO:K01998]
RPSI07_mp0016  livM; leucine/isoleucine/valine transporter permease subunit (transmembrane abc transporter) [KO:K01998]
RPSI07_1793  putative ABC-type branched-chain amino acid transporter, membrane component [KO:K01998]
RPSI07_1175  putative transmembrane abc transporter protein [KO:K01998]
RPSI07_mp1339  putative ABC-type branched-chain amino acid transport system, permease component [KO:K01998]
RPSI07_0100  putative branched-chain amino acid transport system permease, ATP binding component [KO:K01995]
RPSI07_1036  livG; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01995]
RPSI07_mp0017  livG; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01995]
RPSI07_1176  livG; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01995]
RPSI07_1794  putative ABC-type branched-chain amino acid transporter, atp_binding component [KO:K01995]
RPSI07_mp1340  livG; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01995]
RPSI07_0101  putative leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily (livF) [KO:K01996]
RPSI07_1037  livF; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01996]
RPSI07_mp0018  livF; Leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01996]
RPSI07_1795  putative ABC-type branched-chain amino acid transporter, ATP_binding component [KO:K01996]
RPSI07_1177  livF; High-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
RPSI07_mp0605  livF; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01996]
RPSI07_mp1341  livF; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily; Fe(3+)-transporting ATPase [KO:K01996]
RPSI07_0159  solR; Transcriptional activator protein solR [KO:K19666]
RPSI07_0157  conserved hypothethical protein [KO:K20275]
RPSI07_0158  conserved hypothethical protein [KO:K20275]
RPSI07_0156  putative sugar-binding lectin protein [KO:K20277]
RPSI07_0649  fadD; acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) [KO:K01897] [EC:6.2.1.3]
RPSI07_2826  fadD; acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) [KO:K01897] [EC:6.2.1.3]
RPSI07_3313  putative long-chain-fatty-acid--coa ligase protein (fadD2) [KO:K01897] [EC:6.2.1.3]
RPSI07_mp0740  putative transcription regulator protein [KO:K10914]
RPSI07_2623  ribD; bifunctional protein: diaminohydroxyphosphoribosylaminopyrimidine deaminase (N-terminal); 5-amino-6-(5-phosphoribosylamino) uracil reductase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
RPSI07_mp0753  outer membrane drug efflux lipoprotein [KO:K18139]
RPSI07_3371  putative outer membrane protein (Probable drug efflux lipoprotein) [KO:K18139]
RPSI07_1979  putative outer membrane efflux protein [KO:K18139]
RPSI07_0635  putative periplasmic dipeptide transport protein precursor (dppA-like or gsiB-like) [KO:K02035]
RPSI07_1422  putative extracellular solute-binding protein [KO:K02035]
RPSI07_1507  dppA; dipeptide transport protein [KO:K02035]
RPSI07_mp1036  putative ABC transporter; dipeptide-binding protein [KO:K02035]
RPSI07_mp0723  Extracellular solute-binding protein, family 5 precursor [KO:K02035]
RPSI07_3334  dppA; periplasmic dipeptide transport protein [KO:K02035]
RPSI07_0636  dppB; dipeptide transport protein 1 (ABC superfamily, membrane component) [KO:K02033]
RPSI07_mp0724  dppB; dipeptide transporter, membrane component of ABC superfamily [KO:K02033]
RPSI07_mp1035  Putative dipeptide transport system permease protein dppB [KO:K02033]
RPSI07_1511  dppB; dipeptide transport protein 1 (ABC superfamily, membrane component) [KO:K02033]
RPSI07_mp0725  Binding-protein-dependent transport systems inner membrane component [KO:K02034]
RPSI07_mp1034  putative dipeptide transport system permease protein dppC [KO:K02034]
RPSI07_0637  dppC; Dipeptide transport system permease protein (ABC superfamily, membrane) [KO:K02034]
RPSI07_1510  dppC; Dipeptide transport system permease protein (ABC superfamily, membrane) [KO:K02034]
RPSI07_mp0726  dppD; dipeptide ABC transporter atp-binding domain [KO:K02031]
RPSI07_1509  dppD; Dipeptide transport ATP-binding (ABC superfamily) [KO:K02031]
RPSI07_0638  dppD; Dipeptide transport ATP-binding (ABC superfamily) [KO:K02031]
RPSI07_mp1033  putative dipeptide transport ATP-binding protein dppD [KO:K02031 K02032]
RPSI07_0639  dppF; Dipeptide transport ATP-binding (ABC superfamily) [KO:K02032]
RPSI07_1508  dppF; Dipeptide transport ATP-binding (ABC superfamily) [KO:K02032]
RPSI07_mp0727  dppF; dipeptide ABC transporter, ATP-binding protein [KO:K02032]
RPSI07_3382  yidC; cytoplasmic insertase, essential for proper integration of ATPase into the membrane [KO:K03217]
RPSI07_0863  putative extracellular protease precursor, subtilisin-like protein [KO:K14645] [EC:3.4.21.-]
RPSI07_0862  putative extracellular subtilisin-like protease precursor [KO:K14645] [EC:3.4.21.-]
RPSI07_0457  secE; preprotein translocase membrane subunit [KO:K03073]
RPSI07_1366  secG; preprotein translocase membrane subunit [KO:K03075]
RPSI07_0499  secY; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) [KO:K03076]
RPSI07_0797  yajC; protein translocase auxillary subunit [KO:K03210]
RPSI07_0673  secA; preprotein translocase, ATPase secretion component (General Secretory Pathway) [KO:K03070] [EC:7.4.2.8]
RPSI07_3021  ftsY; Signal recognition particle (SRP) GTPase [KO:K03110]
RPSI07_3053  secB; molecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway) [KO:K03071]
RPSI07_0696  ffh; Signal Recognition Particle (SRP) component with 4.5S RNA (ffs) [KO:K03106] [EC:3.6.5.4]
RPSI07_3091  plcN; Non-hemolytic phospholipase C precursor (PLC-N) [KO:K01114] [EC:3.1.4.3]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
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Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
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FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
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Int J Mol Sci 14:16386-401 (2013)
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Reference
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Front Microbiol 4:356 (2013)
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Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
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Int J Mol Sci 14:19309-40 (2013)
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PMID:20738404
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FEMS Microbiol Rev 35:247-74 (2011)
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The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
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Biomed Res Int 2015:759348 (2015)
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Reference
PMID:11544214
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  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
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J Bacteriol 183:5529-34 (2001)
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Mol Plant Microbe Interact 14:969-79 (2001)
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Reference
PMID:19696934
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The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
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PLoS Pathog 5:e1000553 (2009)
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Reference
PMID:22144490
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Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
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Infect Immun 80:688-703 (2012)
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PMID:23160491
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Fucose sensing regulates bacterial intestinal colonization.
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Nature 492:113-7 (2012)
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PMID:22778415
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Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
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Proc Natl Acad Sci U S A 109:12141-6 (2012)
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PMID:14617175
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Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
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Mol Microbiol 50:511-25 (2003)
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PMID:12448738
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J Bacteriol 181:3816-23 (1999)
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PMID:7665477
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Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
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J Bacteriol 177:5000-8 (1995)
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Reference
PMID:19761612
  Authors
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  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
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BMC Genomics 10:441 (2009)
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Reference
PMID:16041013
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  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
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Infect Immun 73:4982-92 (2005)
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PMID:22949660
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  Title
Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
  Journal
Proc Natl Acad Sci U S A 109:15479-84 (2012)
DOI:10.1073/pnas.1205037109
Reference
PMID:23799665
  Authors
Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
  Title
Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
  Journal
Virulence 4:400-9 (2013)
DOI:10.4161/viru.25338
Reference
PMID:21166386
  Authors
Deng Y, Wu J, Tao F, Zhang LH
  Title
Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
  Journal
Chem Rev 111:160-73 (2011)
DOI:10.1021/cr100354f
Reference
PMID:21227698
  Authors
Ryan RP, Dow JM
  Title
Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
  Journal
Trends Microbiol 19:145-52 (2011)
DOI:10.1016/j.tim.2010.12.003
Reference
PMID:15522077
  Authors
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
  Title
Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
  Journal
Mol Microbiol 54:921-34 (2004)
DOI:10.1111/j.1365-2958.2004.04338.x
Reference
PMID:17376080
  Authors
Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
  Title
Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
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Mol Microbiol 64:165-79 (2007)
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Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
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J Bacteriol 193:3871-8 (2011)
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Mol Cell 42:199-209 (2011)
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LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
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Curr Microbiol 62:101-10 (2011)
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Front Microbiol 6:1174 (2015)
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Mol Cell 32:150-8 (2008)
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J Bacteriol 191:3919-27 (2009)
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Sensors (Basel) 12:2519-38 (2012)
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Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.
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J Bacteriol 194:3961-71 (2012)
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Toxins (Basel) 6:2239-55 (2014)
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Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis.
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Peptides 25:1405-14 (2004)
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Bacterial quorum sensing: its role in virulence and possibilities for its control.
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Cold Spring Harb Perspect Med 2:a012427 (2012)
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Exploiting quorum sensing to confuse bacterial pathogens.
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Microbiol Mol Biol Rev 77:73-111 (2013)
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Healthcare epidemiology: quorum sensing: bacteria talk sense.
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Clin Infect Dis 47:1070-6 (2008)
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Related
pathway
rsl00405  Phenazine biosynthesis
rsl02040  Flagellar assembly
KO pathway
ko02024   
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