KEGG   PATHWAY: sbg00260
Entry
sbg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella bongori NCTC 12419
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sbg00260  Glycine, serine and threonine metabolism
sbg00260

Module
sbg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sbg00260]
sbg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sbg00260]
sbg_M00621  Glycine cleavage system [PATH:sbg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella bongori NCTC 12419 [GN:sbg]
Gene
SBG_3665  lysC; lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
SBG_0001  thrA; aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SBG_3600  metL; bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SBG_3133  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SBG_0002  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
SBG_0003  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SBG_0795  ybjU; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SBG_2329  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SBG_0973  putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic region [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SBG_3243  yiaE; putative 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SBG_2575  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SBG_2272  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SBG_2883  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SBG_0655  gpmA; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
SBG_3992  gpmB; putative phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]
SBG_3286  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SBG_2655  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SBG_0831  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SBG_3985  serB; putative phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SBG_1338  putative oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SBG_3291  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SBG_3290  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SBG_2646  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
SBG_2648  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SBG_0149  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBG_2647  gcvH; glycine cleavage system H protein [KO:K02437]
SBG_2370  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
SBG_2586  sdaB; L-serine dehydratase 2 (L-serine deaminase 2) [KO:K01752] [EC:4.3.1.17]
SBG_1683  sdaA; L-serine deaminase 1 [KO:K01752] [EC:4.3.1.17]
SBG_2009  sdaC2; putative L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SBG_2877  tdcG; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SBG_2881  tdcB; catabolic threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SBG_3449  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
SBG_2620  ygeA; conserved hypothetical protein [KO:K25316] [EC:5.1.1.10]
SBG_1589  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SBG_1588  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sbg00010  Glycolysis / Gluconeogenesis
sbg00020  Citrate cycle (TCA cycle)
sbg00230  Purine metabolism
sbg00250  Alanine, aspartate and glutamate metabolism
sbg00270  Cysteine and methionine metabolism
sbg00290  Valine, leucine and isoleucine biosynthesis
sbg00300  Lysine biosynthesis
sbg00330  Arginine and proline metabolism
sbg00460  Cyanoamino acid metabolism
sbg00470  D-Amino acid metabolism
sbg00564  Glycerophospholipid metabolism
sbg00600  Sphingolipid metabolism
sbg00620  Pyruvate metabolism
sbg00630  Glyoxylate and dicarboxylate metabolism
sbg00640  Propanoate metabolism
sbg00680  Methane metabolism
sbg00860  Porphyrin metabolism
sbg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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