PATHWAY: sgh00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Sinocyclocheilus grahami (golden-line barbel)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
sgh_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sgh00020 ]
sgh_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:sgh00020 ]
Other DBs
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:
sgh ]
Gene
107554778 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
107563611 dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658 ] [EC:2.3.1.61 ]
107574295 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
107566633 sdha; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234 ] [EC:1.3.5.1 ]
107593926 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
107591143 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
107600074 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236 ]
107557876 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236 ]
107577886 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial-like [KO:K00237 ]
107586238 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial [KO:K00237 ]
107598448 succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial-like isoform X1 [KO:K00237 ]
107601715 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial-like [KO:K00237 ]
107592287 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial-like isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
107599948 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial-like isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
107586777 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like [KO:K00161 ] [EC:1.2.4.1 ]
107551651 dlat; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627 ] [EC:2.3.1.12 ]
107603285 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
sgh00053 Ascorbate and aldarate metabolism
sgh00250 Alanine, aspartate and glutamate metabolism
sgh00280 Valine, leucine and isoleucine degradation
sgh00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
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