KEGG   PATHWAY: shr04721
Entry
shr04721                    Pathway                                
Name
Synaptic vesicle cycle - Sarcophilus harrisii (Tasmanian devil)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
shr04721  Synaptic vesicle cycle
shr04721

Other DBs
GO: 0016079 0048488
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100925130  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
100916325  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
100933876  SLC18A1; chromaffin granule amine transporter [KO:K08155]
100920172  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
100930519  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
100928483  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
100913698  SLC17A8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
100925625  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
100920124  VAMP2; vesicle-associated membrane protein 2 [KO:K13504]
100927659  RAB3A; ras-related protein Rab-3A [KO:K07882]
100918553  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
100914393  STX1A; syntaxin-1A [KO:K04560]
100920757  STX3; syntaxin-3 isoform X1 [KO:K08486]
100914181  STX2; syntaxin-2 isoform X1 [KO:K08486]
100929548  STX1B; syntaxin-1B [KO:K08486]
100918336  STXBP1; syntaxin-binding protein 1 isoform X2 [KO:K15292]
100915455  UNC13C; protein unc-13 homolog C isoform X1 [KO:K15293]
100918963  protein unc-13 homolog B isoform X10 [KO:K15293]
100920361  UNC13A; protein unc-13 homolog A isoform X1 [KO:K15293]
100931896  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
100931169  CPLX1; complexin-1 [KO:K15294]
100931972  CPLX2; complexin-2 [KO:K15294]
100934755  CPLX3; complexin-3 [KO:K15295]
100924452  CPLX4; complexin-4 [KO:K15295]
100925240  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100933192  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100919423  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
100933822  NAPA; alpha-soluble NSF attachment protein isoform X1 [KO:K15296]
100925008  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
100926536  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
100925580  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
100926895  CLTA; clathrin light chain A isoform X1 [KO:K04644]
100933527  CLTB; clathrin light chain B isoform X2 [KO:K04645]
100920538  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
100935396  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
100924206  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
100921341  AP2A1; AP-2 complex subunit alpha-1 [KO:K11824]
100913959  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
100930280  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
116423036  AP2S1; AP-2 complex subunit sigma [KO:K11827]
100934335  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100930744  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100931454  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100924709  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
100915395  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100920765  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100927023  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100934113  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100923734  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100913521  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100921352  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152]
100930285  V-type proton ATPase subunit e 2 [KO:K02153]
100924440  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
100917978  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105749382  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100934805  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100919520  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100928254  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
100913849  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100931636  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100924463  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100918992  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100926814  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
100923309  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
100914957  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
100927144  sodium-dependent serotonin transporter-like [KO:K05037]
100923444  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
100928227  SLC6A5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
100918472  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X1 [KO:K05038]
100934652  SLC6A7; sodium-dependent proline transporter [KO:K05040]
111719448  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
100917782  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
100921451  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
100926284  SLC1A1; excitatory amino acid transporter 3 isoform X1 [KO:K05612]
100923371  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
100932840  SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
100922279  SLC1A6; excitatory amino acid transporter 4 [KO:K05617]
100922050  SLC1A7; excitatory amino acid transporter 5 [KO:K05618]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
shr04144  Endocytosis
shr04724  Glutamatergic synapse
shr04725  Cholinergic synapse
shr04726  Serotonergic synapse
shr04727  GABAergic synapse
shr04728  Dopaminergic synapse
KO pathway
ko04721   
LinkDB

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