KEGG   PATHWAY: slb00260
Entry
slb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Sugiyamaella lignohabitans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
slb00260  Glycine, serine and threonine metabolism
slb00260

Module
slb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:slb00260]
slb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:slb00260]
slb_M00621  Glycine cleavage system [PATH:slb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sugiyamaella lignohabitans [GN:slb]
Gene
AWJ20_3147  HOM3; aspartate kinase [KO:K00928] [EC:2.7.2.4]
AWJ20_537  HOM6; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AWJ20_2491  THR1; homoserine kinase [KO:K00872] [EC:2.7.1.39]
AWJ20_2351  THR4; threonine synthase THR4 [KO:K01733] [EC:4.2.3.1]
AWJ20_451  GLY1; threonine aldolase GLY1 [KO:K01620] [EC:4.1.2.48]
AWJ20_4628  SHM2; glycine hydroxymethyltransferase SHM2 [KO:K00600] [EC:2.1.2.1]
AWJ20_4267  SHM1; glycine hydroxymethyltransferase SHM1 [KO:K00600] [EC:2.1.2.1]
AWJ20_5243  AGX1; alanine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AWJ20_3815  GPM1; phosphoglycerate mutase GPM1 [KO:K01834] [EC:5.4.2.11]
AWJ20_4520  TDA10; Tda10p [KO:K15918] [EC:2.7.1.31]
AWJ20_3411  SER33; phosphoglycerate dehydrogenase SER33 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AWJ20_4903  SER1; O-phospho-L-serine:2-oxoglutarate transaminase [KO:K00831] [EC:2.6.1.52]
AWJ20_3156  SER2; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AWJ20_1310  HEM1; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
AWJ20_2943  copper-containing amine oxidase [KO:K00276] [EC:1.4.3.21]
AWJ20_132  AMO2; putative peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AWJ20_1415  AMO2; putative peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AWJ20_3858  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
AWJ20_1586  GCV1; glycine decarboxylase subunit T [KO:K00605] [EC:2.1.2.10]
AWJ20_96  LPD1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AWJ20_1101  GCV3; glycine decarboxylase subunit H [KO:K02437]
AWJ20_2748  D-amino acid oxidase (predicted) [KO:K00273] [EC:1.4.3.3]
AWJ20_3355  hypothetical protein [KO:K00273] [EC:1.4.3.3]
AWJ20_4531  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AWJ20_5157  CYS4; cystathionine beta-synthase CYS4 [KO:K01697] [EC:4.2.1.22]
AWJ20_3470  CYS3; cystathionine gamma-lyase CYS3 [KO:K01758] [EC:4.4.1.1]
AWJ20_1948  ILV1; threonine ammonia-lyase ILV1 [KO:K01754] [EC:4.3.1.19]
AWJ20_186  CHA1; L-serine/L-threonine ammonia-lyase CHA1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AWJ20_3241  CHA1; L-serine/L-threonine ammonia-lyase CHA1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AWJ20_34  DSD1; D-serine ammonia-lyase DSD1 [KO:K20498] [EC:4.3.1.18]
AWJ20_4453  DSD1; D-serine ammonia-lyase DSD1 [KO:K20498] [EC:4.3.1.18]
AWJ20_2071  TRP5; tryptophan synthase TRP5 [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
slb00010  Glycolysis / Gluconeogenesis
slb00020  Citrate cycle (TCA cycle)
slb00230  Purine metabolism
slb00250  Alanine, aspartate and glutamate metabolism
slb00270  Cysteine and methionine metabolism
slb00290  Valine, leucine and isoleucine biosynthesis
slb00300  Lysine biosynthesis
slb00330  Arginine and proline metabolism
slb00460  Cyanoamino acid metabolism
slb00470  D-Amino acid metabolism
slb00564  Glycerophospholipid metabolism
slb00600  Sphingolipid metabolism
slb00620  Pyruvate metabolism
slb00630  Glyoxylate and dicarboxylate metabolism
slb00640  Propanoate metabolism
slb00680  Methane metabolism
slb00860  Porphyrin metabolism
slb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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