KEGG   PATHWAY: srx04330
Entry
srx04330                    Pathway                                
Name
Notch signaling pathway - Sinocyclocheilus rhinocerous
Description
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
srx04330  Notch signaling pathway
srx04330

Other DBs
GO: 0007219
Organism
Sinocyclocheilus rhinocerous [GN:srx]
Gene
107728223  delta-like protein C isoform X1 [KO:K06051]
107721368  delta-like protein 4 [KO:K06051]
107729897  delta-like protein A [KO:K06051]
107717858  delta-like protein D [KO:K06051]
107729127  delta-like protein C isoform X1 [KO:K06051]
107757508  delta-like protein B [KO:K06051]
107746130  delta-like protein A [KO:K06051]
107739369  delta-like protein 4 [KO:K06051]
107746357  delta-like protein B [KO:K06051]
107754741  delta-like protein D [KO:K06051]
107705411  jag1; protein jagged-1 isoform X1 [KO:K06052]
107756988  protein jagged-1a-like [KO:K06052]
107739890  protein jagged-1b-like [KO:K06052]
107747432  protein jagged-1a [KO:K06052]
107724379  protein jagged-2-like [KO:K21635]
107705348  protein jagged-2-like [KO:K21635]
107718403  protein jagged-2-like isoform X1 [KO:K21635]
107755239  LOW QUALITY PROTEIN: protein jagged-2-like [KO:K21635]
107758333  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
107715074  beta-1,3-N-acetylglucosaminyltransferase manic fringe-like isoform X1 [KO:K05948] [EC:2.4.1.222]
107757470  beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
107708990  beta-1,3-N-acetylglucosaminyltransferase radical fringe-like [KO:K05948] [EC:2.4.1.222]
107753450  lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
107705975  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1-like [KO:K02599]
107720248  neurogenic locus notch homolog protein 1-like isoform X1 [KO:K02599]
107745520  neurogenic locus notch homolog protein 1-like [KO:K02599]
107737167  neurogenic locus notch homolog protein 1 [KO:K02599]
107717553  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2-like [KO:K20994]
107750854  neurogenic locus notch homolog protein 2-like isoform X1 [KO:K20994]
107711261  neurogenic locus notch homolog protein 2-like isoform X1 [KO:K20995]
107757359  neurogenic locus notch homolog protein 2-like [KO:K20995]
107708045  recombining binding protein suppressor of hairless-like protein [KO:K06053]
107714197  recombining binding protein suppressor of hairless-like [KO:K06053]
107707427  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
107742494  recombining binding protein suppressor of hairless-like isoform X1 [KO:K06053]
107723895  rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
107757894  suppressor of hairless protein homolog [KO:K06053]
107716081  transcription factor HES-4-B-like [KO:K06054]
107737700  transcription factor HES-4-B-like [KO:K06054]
107722674  transcription factor HES-1-like [KO:K06054]
107711114  transcription factor HES-1-like [KO:K06054]
107706549  enhancer of split mbeta protein-like [KO:K06055]
107712946  transcription factor HES-5-like [KO:K06055]
107712673  transcription factor HES-5-like [KO:K06055]
107712674  transcription factor HES-5-like [KO:K06055]
107735212  transcription factor HES-5-like [KO:K06055]
107750997  transcription factor HES-5-like [KO:K06055]
107737705  transcription factor HES-5-like [KO:K06055]
107737706  transcription factor HES-5-like [KO:K06055]
107712987  transcription factor HES-5-like isoform X1 [KO:K06055]
107712988  transcription factor HES-5-like [KO:K06055]
107712989  transcription factor HES-5-like [KO:K06055]
107746004  transcription factor HES-5-like [KO:K06055]
107706547  transcription factor HES-5-like [KO:K06055]
107706548  transcription factor HES-5-like [KO:K06055]
107712654  transcription factor HES-5-like [KO:K06055]
107712963  transcription factor HES-5-like [KO:K06055]
107710664  hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
107717129  hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
107724307  hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
107727582  hairy/enhancer-of-split related with YRPW motif protein 2-like [KO:K09091]
107743827  hey1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
107744242  notch-regulated ankyrin repeat-containing protein A [KO:K26480]
107713312  notch-regulated ankyrin repeat-containing protein A-like [KO:K26480]
107717599  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107709335  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107731941  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
107727485  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107749512  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
107708824  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
107758060  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107727776  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
107738023  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
107758530  numbl; numb-like protein [KO:K06057]
107758710  protein numb homolog [KO:K06057]
107749658  numb-like protein [KO:K06057]
107753345  protein numb homolog [KO:K06057]
107744345  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
107752199  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
107740281  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
107751942  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
107731926  E3 ubiquitin-protein ligase DTX4-like [KO:K06058] [EC:2.3.2.27]
107730372  dtx1; E3 ubiquitin-protein ligase DTX1 isoform X1 [KO:K06058] [EC:2.3.2.27]
107716192  probable E3 ubiquitin-protein ligase DTX3 isoform X1 [KO:K06058] [EC:2.3.2.27]
107721025  E3 ubiquitin-protein ligase DTX1-like [KO:K06058] [EC:2.3.2.27]
107720303  E3 ubiquitin-protein ligase DTX4-like [KO:K06058] [EC:2.3.2.27]
107711637  E3 ubiquitin-protein ligase DTX4-like [KO:K06058] [EC:2.3.2.27]
107708624  uncharacterized protein LOC107708624 [KO:K06058] [EC:2.3.2.27]
107709752  probable E3 ubiquitin-protein ligase DTX2 [KO:K06058] [EC:2.3.2.27]
107757659  uncharacterized protein LOC107757659 [KO:K06058] [EC:2.3.2.27]
107744330  dtx2; probable E3 ubiquitin-protein ligase DTX2 [KO:K06058] [EC:2.3.2.27]
107742417  E3 ubiquitin-protein ligase DTX3L-like [KO:K06058] [EC:2.3.2.27]
107746726  E3 ubiquitin-protein ligase DTX4-like isoform X1 [KO:K06058] [EC:2.3.2.27]
107747475  E3 ubiquitin-protein ligase DTX3L-like [KO:K06058] [EC:2.3.2.27]
107745454  probable E3 ubiquitin-protein ligase DTX3 isoform X1 [KO:K06058] [EC:2.3.2.27]
107746801  probable E3 ubiquitin-protein ligase DTX2 [KO:K06058] [EC:2.3.2.27]
107721298  adam17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
107756583  disintegrin and metalloproteinase domain-containing protein 17-like isoform X1 [KO:K06059] [EC:3.4.24.86]
107707689  disintegrin and metalloproteinase domain-containing protein 17-like isoform X1 [KO:K06059] [EC:3.4.24.86]
107752755  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
107723284  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
107753355  presenilin-1 [KO:K04505] [EC:3.4.23.-]
107757025  presenilin-2 [KO:K04522] [EC:3.4.23.-]
107747431  presenilin-2-like [KO:K04522] [EC:3.4.23.-]
107747663  gamma-secretase subunit PEN-2-like [KO:K06170]
107745203  gamma-secretase subunit PEN-2 [KO:K06170]
107750207  ncstn; nicastrin [KO:K06171]
107726318  nicastrin-like [KO:K06171]
107715838  gamma-secretase subunit Aph-1b-like [KO:K06172]
107741400  gamma-secretase subunit Aph-1b [KO:K06172]
107750610  gamma-secretase subunit Aph-1b-like [KO:K06172]
107737132  gamma-secretase subunit Aph-1b-like [KO:K06172]
107722438  mastermind-like protein 1 [KO:K06061]
107714095  mastermind-like protein 2 [KO:K06061]
107712021  mastermind-like protein 3 [KO:K06061]
107733434  mastermind-like protein 1 [KO:K06061]
107744020  mastermind-like protein 2 isoform X1 [KO:K06061]
107737085  mastermind-like protein 3 [KO:K06061]
107755349  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107723602  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107709650  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107718619  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107715623  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107742089  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107734181  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107748789  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107755568  histone acetyltransferase KAT2A-like isoform X1 [KO:K06062] [EC:2.3.1.48]
107748684  histone acetyltransferase KAT2B-like [KO:K06062] [EC:2.3.1.48]
107729177  histone acetyltransferase KAT2A-like [KO:K06062] [EC:2.3.1.48]
107739562  histone acetyltransferase KAT2B-like [KO:K06062] [EC:2.3.1.48]
107747960  SNW domain-containing protein 1-like [KO:K06063]
107729277  C-terminal-binding protein 1-like [KO:K04496] [EC:1.1.1.428]
107733778  proline-rich protein 36-like isoform X1 [KO:K04496] [EC:1.1.1.428]
107742495  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
107742535  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
107754460  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
107754461  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
107734199  C-terminal-binding protein 2-like [KO:K04496] [EC:1.1.1.428]
107708208  protein groucho-2-like [KO:K04497]
107738704  protein groucho-2 isoform X1 [KO:K04497]
107719561  transducin-like enhancer protein 1 [KO:K04497]
107719559  transducin-like enhancer protein 4 [KO:K04497]
107729686  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
107729670  transducin-like enhancer protein 4 [KO:K04497]
107740439  transducin-like enhancer protein 3 [KO:K04497]
107755017  protein groucho-1-like [KO:K04497]
107742750  nuclear receptor corepressor 2-like [KO:K06065]
107753125  nuclear receptor corepressor 2-like isoform X1 [KO:K06065]
107742955  cir1; corepressor interacting with RBPJ 1 [KO:K06066]
107716126  msx2-interacting protein-like [KO:K25100]
107719036  msx2-interacting protein-like isoform X1 [KO:K25100]
107737932  LOW QUALITY PROTEIN: msx2-interacting protein-like [KO:K25100]
107709289  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
107745719  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
107714879  LOW QUALITY PROTEIN: ataxin-1-like [KO:K23616]
107723489  ataxin-1-like isoform X1 [KO:K23616]
107724277  ataxin-1-like [KO:K23616]
107738335  ataxin-1-like [KO:K23616]
107743820  ataxin-1-like [KO:K23616]
107747387  atxn1l; ataxin-1-like [KO:K23616]
107754864  uncharacterized protein LOC107754864 [KO:K23616]
107730479  uncharacterized protein LOC107730479 [KO:K23616]
Compound
C22528  Notch intracellular domain
Reference
PMID:15288257
  Authors
Hansson EM, Lendahl U, Chapman G.
  Title
Notch signaling in development and disease.
  Journal
Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011
Reference
PMID:15300010
  Authors
Callahan R, Egan SE.
  Title
Notch signaling in mammary development and oncogenesis.
  Journal
J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81
Reference
PMID:15288258
  Authors
Zweidler-McKay PA, Pear WS.
  Title
Notch and T cell malignancy.
  Journal
Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012
Reference
PMID:15288260
  Authors
Wu L, Griffin JD.
  Title
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
  Journal
Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014
Reference
PMID:15585829
  Authors
Tsukumo S, Yasutomo K.
  Title
Notch governing mature T cell differentiation.
  Journal
J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109
Reference
PMID:12464310
  Authors
Haltiwanger RS.
  Title
Regulation of signal transduction pathways in development by glycosylation.
  Journal
Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8
Reference
PMID:15272268
  Authors
Koo EH, Kopan R.
  Title
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.
  Journal
Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065
Reference
PMID:11896183
  Authors
Okano H, Imai T, Okabe M.
  Title
Musashi: a translational regulator of cell fate.
  Journal
J Cell Sci 115:1355-9 (2002)
Reference
PMID:12417415
  Authors
Haltiwanger RS, Stanley P.
  Title
Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
  Journal
Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2
Reference
PMID:12015972
  Authors
Das G, Reynolds-Kenneally J, Mlodzik M.
  Title
The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.
  Journal
Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8
Reference
PMID:10028969
  Authors
Cooper MT, Bray SJ.
  Title
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.
  Journal
Nature 397:526-30 (1999)
DOI:10.1038/17395
Reference
PMID:12681948
  Authors
Tanigaki K, Kuroda K, Han H, Honjo T.
  Title
Regulation of B cell development by Notch/RBP-J signaling.
  Journal
Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3
Related
pathway
srx04010  MAPK signaling pathway
KO pathway
ko04330   
LinkDB

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