KEGG   PATHWAY: svs00480
Entry
svs00480                    Pathway                                
Name
Glutathione metabolism - Setaria viridis (green foxtail)
Class
Metabolism; Metabolism of other amino acids
Pathway map
svs00480  Glutathione metabolism
svs00480

Module
svs_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:svs00480]
Other DBs
GO: 0006749
Organism
Setaria viridis (green foxtail) [GN:svs]
Gene
117862633  glutathione hydrolase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
117856693  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
117841535  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
117865446  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
117837378  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
117850004  glutamate--cysteine ligase A, chloroplastic [KO:K01919] [EC:6.3.2.2]
117855700  glutamate--cysteine ligase A, chloroplastic-like isoform X1 [KO:K01919] [EC:6.3.2.2]
117848103  glutathione synthetase, chloroplastic-like isoform X1 [KO:K21456] [EC:6.3.2.3]
117833963  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
117844857  leucine aminopeptidase 2, chloroplastic-like isoform X1 [KO:K01255] [EC:3.4.11.1]
117860987  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
117845443  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117845592  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
117845702  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
117845808  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
117839260  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
117839487  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117847134  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117847252  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
117839952  protein IN2-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
117840055  glutathione S-transferase U24-like [KO:K00799] [EC:2.5.1.18]
117847544  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
117847665  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
117847694  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
117833363  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117833808  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117835147  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
117835174  probable glutathione S-transferase GSTU6 isoform X1 [KO:K00799] [EC:2.5.1.18]
117835175  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117835443  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
117835632  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117835633  uncharacterized protein LOC117835633 [KO:K00799] [EC:2.5.1.18]
117835634  uncharacterized protein LOC117835634 [KO:K00799] [EC:2.5.1.18]
117835636  uncharacterized protein LOC117835636 [KO:K00799] [EC:2.5.1.18]
117835755  protein IN2-1-like [KO:K00799] [EC:2.5.1.18]
117835905  protein IN2-1 homolog B isoform X1 [KO:K00799] [EC:2.5.1.18]
117836218  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
117836451  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
117836542  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117836543  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117836657  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
117836741  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
117837203  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
117842368  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
117838019  probable glutathione S-transferase GSTU6 isoform X1 [KO:K00799] [EC:2.5.1.18]
117838387  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
117838514  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
117838515  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
117838687  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
117838688  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
117845371  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
117861876  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
117851448  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
117851925  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117865626  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117854725  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
117854883  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117854929  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
117854930  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
117855069  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
117855265  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117855326  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117855375  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117855443  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117855444  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117855583  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117855780  probable glutathione S-transferase GSTF1 isoform X1 [KO:K00799] [EC:2.5.1.18]
117855876  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117856338  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
117856593  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117857122  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
117857518  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117857520  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117857521  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117857522  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
117857523  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117858050  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
117858181  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
117858888  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
117859266  glutathione S-transferase 4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
117835637  uncharacterized protein LOC117835637 [KO:K00799] [EC:2.5.1.18]
117850548  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
117853206  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
117841522  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
117838415  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
117838509  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
117847610  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
117863842  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
117857800  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
117833124  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
117852099  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
117855629  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
117839537  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
117837487  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
117860511  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
117863960  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
117864245  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
117839298  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
117847054  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
117834752  probable glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
117860133  uncharacterized protein LOC117860133 isoform X1 [KO:K00432] [EC:1.11.1.9]
117863573  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial [KO:K00432] [EC:1.11.1.9]
117865800  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
117853171  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
117845850  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
117845657  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
117843880  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
117843115  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
117859962  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
117853865  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
117837486  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
117842945  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
117859935  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
117860239  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
117863384  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
117865913  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
117865975  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
117841447  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
117853118  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
117858470  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
117864108  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
117851309  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
svs00220  Arginine biosynthesis
svs00250  Alanine, aspartate and glutamate metabolism
svs00270  Cysteine and methionine metabolism
svs00430  Taurine and hypotaurine metabolism
svs00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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