KEGG   PATHWAY: tdc00260
Entry
tdc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Triticum dicoccoides (wild emmer wheat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tdc00260  Glycine, serine and threonine metabolism
tdc00260

Module
tdc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:tdc00260]
tdc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:tdc00260]
tdc_M00555  Betaine biosynthesis, choline => betaine [PATH:tdc00260]
tdc_M00621  Glycine cleavage system [PATH:tdc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Triticum dicoccoides (wild emmer wheat) [GN:tdc]
Gene
119310670  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
119312833  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
119278259  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
119270192  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
119287419  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
119339597  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
119301233  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
119308766  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
119311901  aspartate-semialdehyde dehydrogenase-like [KO:K00133] [EC:1.2.1.11]
119303233  aspartate-semialdehyde dehydrogenase-like [KO:K00133] [EC:1.2.1.11]
119300898  bifunctional aspartokinase/homoserine dehydrogenase 1-like [KO:K00003] [EC:1.1.1.3]
119308410  bifunctional aspartokinase/homoserine dehydrogenase 1-like [KO:K00003] [EC:1.1.1.3]
119325837  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
119365736  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
119318725  homoserine kinase-like isoform X1 [KO:K00872] [EC:2.7.1.39]
119320663  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
119356544  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
119276691  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
119349349  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
119355286  threonine synthase 1, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
119268748  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
119289952  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
119292085  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
119365006  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
119365316  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
119294206  probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]
119355862  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
119304171  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
119304181  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
119275785  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
119365935  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
119277775  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
119295016  serine hydroxymethyltransferase 1, mitochondrial [KO:K00600] [EC:2.1.2.1]
119356710  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
119269769  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
119286723  serine hydroxymethyltransferase 1, mitochondrial [KO:K00600] [EC:2.1.2.1]
119339068  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
119339676  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
119333254  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
119338420  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
119345840  glycerate dehydrogenase-like [KO:K15893] [EC:1.1.1.29]
119319132  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
119352830  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119331137  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119352774  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119352823  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119352826  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119352831  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119358674  glyoxylate/hydroxypyruvate/pyruvate reductase 2KGR-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119360282  hydroxyphenylpyruvate reductase-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119361814  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119361856  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119361858  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119361862  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119340473  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
119331030  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
119317826  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
119338210  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
119324692  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
119315196  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
119299402  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
119300856  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
119322893  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
119277387  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
119296262  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
119269393  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
119276746  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
119268798  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
119275971  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119366048  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119330637  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119267601  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119356812  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119339367  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119291461  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
119284710  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
119332409  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
119353637  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
119338260  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
119270735  phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
119362813  phosphoserine phosphatase, chloroplastic-like isoform X1 [KO:K01079] [EC:3.1.3.3]
119364598  copper methylamine oxidase-like [KO:K00276] [EC:1.4.3.21]
119292832  primary amine oxidase 2-like [KO:K00276] [EC:1.4.3.21]
119353081  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
119355470  copper methylamine oxidase-like [KO:K00276] [EC:1.4.3.21]
119284637  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
119362157  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
119276559  glycine dehydrogenase (decarboxylating) 1, mitochondrial-like [KO:K00281] [EC:1.4.4.2]
119268662  glycine dehydrogenase (decarboxylating) 1, mitochondrial-like [KO:K00281] [EC:1.4.4.2]
119365720  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
119356526  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
119327113  dihydrolipoyl dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
119327734  leghemoglobin reductase-like [KO:K00382] [EC:1.8.1.4]
119366632  leghemoglobin reductase-like [KO:K00382] [EC:1.8.1.4]
119367246  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
119322044  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
119362832  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
119316439  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
119317911  glycine cleavage system H protein, mitochondrial-like isoform X1 [KO:K02437]
119322819  glycine cleavage system H protein, mitochondrial [KO:K02437]
119323141  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
119291579  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119348682  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119296203  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119283776  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119284591  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119363905  glutamate--glyoxylate aminotransferase 2 isoform X1 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
119354714  glutamate--glyoxylate aminotransferase 2 isoform X1 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
119340424  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
119318390  betaine aldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
119355407  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
119323872  betaine aldehyde dehydrogenase 2-like [KO:K00130] [EC:1.2.1.8]
119309456  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
119301583  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
119310925  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119310926  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119310929  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119348764  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119284660  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119302129  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119302130  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119294825  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
119368317  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
119296838  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
119299064  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
119286886  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
119308916  uncharacterized protein LOC119308916 [KO:K01754] [EC:4.3.1.19]
119356120  serine racemase-like [KO:K12235] [EC:5.1.1.18]
119294502  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
119312213  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
119349782  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
119303554  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
119328237  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
119336313  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
119328799  tryptophan synthase beta chain 2-like isoform X1 [KO:K06001] [EC:4.2.1.20]
119337308  tryptophan synthase beta chain 2-like isoform X1 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tdc00010  Glycolysis / Gluconeogenesis
tdc00020  Citrate cycle (TCA cycle)
tdc00230  Purine metabolism
tdc00250  Alanine, aspartate and glutamate metabolism
tdc00270  Cysteine and methionine metabolism
tdc00290  Valine, leucine and isoleucine biosynthesis
tdc00300  Lysine biosynthesis
tdc00330  Arginine and proline metabolism
tdc00460  Cyanoamino acid metabolism
tdc00470  D-Amino acid metabolism
tdc00564  Glycerophospholipid metabolism
tdc00600  Sphingolipid metabolism
tdc00620  Pyruvate metabolism
tdc00630  Glyoxylate and dicarboxylate metabolism
tdc00640  Propanoate metabolism
tdc00860  Porphyrin metabolism
tdc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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