KEGG   PATHWAY: tet04148
Entry
tet04148                    Pathway                                
Name
Efferocytosis - Tetrahymena thermophila
Class
Cellular Processes; Transport and catabolism
Pathway map
tet04148  Efferocytosis
tet04148

Organism
Tetrahymena thermophila [GN:tet]
Gene
TTHERM_00600340  diacylglycerol kinase [KO:K04718] [EC:2.7.1.91]
TTHERM_00459289  diacylglycerol kinase [KO:K04718] [EC:2.7.1.91]
TTHERM_00085220  MEK kinase [KO:K04371] [EC:2.7.11.24]
TTHERM_00697080  plant dual-specificity MAP kinase kinase family domain protein [KO:K04368] [EC:2.7.12.2]
TTHERM_00046430  tyrosine phosphatase [KO:K04459] [EC:3.1.3.16 3.1.3.48]
TTHERM_00670180  tyrosine phosphatase [KO:K04459] [EC:3.1.3.16 3.1.3.48]
TTHERM_00151070  dual specificity phosphatase domain protein [KO:K04459] [EC:3.1.3.16 3.1.3.48]
TTHERM_00616330  dual specificity phosphatase domain protein [KO:K04459] [EC:3.1.3.16 3.1.3.48]
TTHERM_00715640  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00294760  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00470548  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_000797949  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00797970  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00797960  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00600310  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00411630  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_01359440  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00840160  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00325570  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_01123860  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00977720  phospholipid-translocating P-type ATPase, flippase family protein [KO:K14802] [EC:7.6.2.1]
TTHERM_00787080  ligand-effect modulator 3 LEM3 family protein [KO:K26935]
TTHERM_00670450  ligand-effect modulator 3 LEM3 family protein [KO:K26935]
TTHERM_00267910  Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP-binding Rac1)-like protein [KO:K04392]
TTHERM_00957580  small guanosine triphosphatase family Ras family protein [KO:K07889]
TTHERM_00614720  Rab-family small GTPase [KO:K07889]
TTHERM_00393150  corvet complex core vacuolar protein [KO:K20178]
TTHERM_00290710  corvet complex core vacuolar protein [KO:K20178]
TTHERM_00716100  corvet complex core vacuolar protein [KO:K20178]
TTHERM_00532700  corvet complex core vacuolar protein [KO:K20178]
TTHERM_01205260  vacuolar sorting-like protein [KO:K20179]
TTHERM_00370870  vps16, amine-terminal region protein [KO:K20180]
TTHERM_00294740  vps16, amine-terminal region protein [KO:K20180]
TTHERM_00463740  vacuolar sorting protein [KO:K20181]
TTHERM_00410250  vacuolar sorting protein, putative [KO:K20181]
TTHERM_00242090  vacuolar sorting protein [KO:K20181]
TTHERM_00292270  vacuolar sorting protein, putative [KO:K20181]
TTHERM_000077749  vacuolar protein sorting-associated protein [KO:K20182]
TTHERM_00355020  Sec1 family protein [KO:K20182]
TTHERM_000777289  transforming growth beta receptor associated protein, putative [KO:K20183]
TTHERM_00470810  small guanosine triphosphatase family (GTPase)-like Ras family protein [KO:K07897]
TTHERM_00462900  pyridoxal-binding domain pyridoxal-dependent decarboxylase [KO:K01581] [EC:4.1.1.17]
TTHERM_00295080  Rieske iron-sulfur protein, ubiquinol-cytochrome C reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
TTHERM_00284110  ab-hydrolase associated lipase region protein [KO:K01052] [EC:3.1.1.13]
TTHERM_00723090  Ab-hydrolase associated lipase region protein [KO:K01052] [EC:3.1.1.13]
TTHERM_00001200  MFS transporter [KO:K07299]
TTHERM_001504069  kinase domain protein [KO:K13302] [EC:2.7.11.1]
TTHERM_01388160  kinase domain protein [KO:K13302] [EC:2.7.11.1]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
tet00010  Glycolysis / Gluconeogenesis
tet04145  Phagosome
KO pathway
ko04148   
LinkDB

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