KEGG   PATHWAY: thk00230
Entry
thk00230                    Pathway                                
Name
Purine metabolism - Thauera sp. K11
Class
Metabolism; Nucleotide metabolism
Pathway map
thk00230  Purine metabolism
thk00230

Module
thk_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:thk00230]
thk_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:thk00230]
thk_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:thk00230]
thk_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:thk00230]
thk_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:thk00230]
Other DBs
GO: 0006163 0042278
Organism
Thauera sp. K11 [GN:thk]
Gene
CCZ27_10230  NUDIX hydrolase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
CCZ27_07365  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
CCZ27_13585  phosphomannomutase/phosphoglucomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
CCZ27_17285  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
CCZ27_00265  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
CCZ27_15260  phosphoribosylpyrophosphate synthetase [KO:K00948] [EC:2.7.6.1]
CCZ27_04455  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
CCZ27_02790  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
CCZ27_04005  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
CCZ27_07810  phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
CCZ27_04620  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
CCZ27_03910  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
CCZ27_11975  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
CCZ27_11980  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
CCZ27_13925  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
CCZ27_02075  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
CCZ27_02795  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
CCZ27_11650  alkaline phosphatase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
CCZ27_04895  5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
CCZ27_11140  hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
CCZ27_04105  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CCZ27_17025  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
CCZ27_10960  IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
CCZ27_02205  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
CCZ27_19745  rdgB; non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
CCZ27_10955  glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
CCZ27_06895  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
CCZ27_19115  guanylate kinase [KO:K00942] [EC:2.7.4.8]
CCZ27_15845  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
CCZ27_12630  ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [KO:K00525] [EC:1.17.4.1]
CCZ27_15850  ribonucleotide reductase [KO:K00526] [EC:1.17.4.1]
CCZ27_07455  ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
CCZ27_16090  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
CCZ27_19105  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
CCZ27_09965  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CCZ27_09975  GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
CCZ27_15255  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
CCZ27_02460  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
CCZ27_02280  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
CCZ27_01855  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
CCZ27_20965  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
CCZ27_21550  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
CCZ27_12085  adenylate kinase [KO:K00939] [EC:2.7.4.3]
CCZ27_00250  phosphorylase [KO:K00988] [EC:2.7.7.5 2.7.7.53]
CCZ27_06320  phosphorylase [KO:K00988] [EC:2.7.7.5 2.7.7.53]
CCZ27_01830  diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
CCZ27_13990  adenylyl-sulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
CCZ27_16360  sulfate adenylyltransferase subunit CysN [KO:K00956] [EC:2.7.7.4]
CCZ27_13995  sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
CCZ27_16355  sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
CCZ27_09720  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
CCZ27_09730  uraD; OHCU decarboxylase [KO:K13485] [EC:4.1.1.97]
CCZ27_00485  Asp/Glu/hydantoin racemase [KO:K16841] [EC:5.1.99.3]
CCZ27_09735  allantoinase PuuE [KO:K16842] [EC:3.5.2.5]
CCZ27_09740  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
CCZ27_09800  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
CCZ27_09745  ureidoglycolate lyase [KO:K01483] [EC:4.3.2.3]
CCZ27_09805  ureidoglycolate lyase [KO:K01483] [EC:4.3.2.3]
CCZ27_17135  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
CCZ27_17140  urease subunit beta [KO:K01429] [EC:3.5.1.5]
CCZ27_17145  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
CCZ27_07600  gamma-glutamyltransferase [KO:K22602] [EC:3.5.1.126]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
thk00030  Pentose phosphate pathway
thk00220  Arginine biosynthesis
thk00250  Alanine, aspartate and glutamate metabolism
thk00260  Glycine, serine and threonine metabolism
thk00340  Histidine metabolism
thk00630  Glyoxylate and dicarboxylate metabolism
thk00730  Thiamine metabolism
thk00740  Riboflavin metabolism
thk00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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