KEGG   PATHWAY: uah00982
Entry
uah00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Ursus arctos (brown bear)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
uah00982  Drug metabolism - cytochrome P450
uah00982

Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113262842  FMO4; dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
113262844  FMO1; flavin-containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
113262845  FMO2; flavin-containing monooxygenase 2 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
113262846  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
113262847  LOW QUALITY PROTEIN: flavin-containing monooxygenase 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
113268763  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
125280867  FMO5; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
113247073  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113247088  glutathione S-transferase theta-4-like isoform X5 [KO:K00799] [EC:2.5.1.18]
113247089  glutathione S-transferase theta-1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
113257838  MGST1; microsomal glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
113244917  GSTM3; glutathione S-transferase Mu 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
113255690  MGST2; microsomal glutathione S-transferase 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
113268693  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
113251904  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
113251905  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
113247021  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
113247025  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
113261183  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
113261185  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
113261186  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
113261187  glutathione S-transferase A3-like isoform X2 [KO:K00799] [EC:2.5.1.18]
125282883  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
125282884  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
130543420  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
130543421  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
113244018  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
113244019  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
113265493  GSTK1; glutathione S-transferase kappa 1 isoform X2 [KO:K13299] [EC:2.5.1.18]
113263135  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
113263118  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
113263120  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
113263121  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
113263119  ADH6; alcohol dehydrogenase 6 isoform X2 [KO:K13952] [EC:1.1.1.1]
113271268  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
113244008  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
113244012  ALDH3B2; aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
113265899  uncharacterized protein LOC113265899 [KO:K00274] [EC:1.4.3.4]
113265900  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
113250605  aldehyde oxidase 2 isoform X2 [KO:K00157] [EC:1.2.3.1]
113250606  AOX1; aldehyde oxidase isoform X2 [KO:K00157] [EC:1.2.3.1]
113250607  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
113250325  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
113262548  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
113262550  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
113262552  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
125283434  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125280979  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283091  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283092  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283435  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283436  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125281344  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
130542426  UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
130542430  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
125283093  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
130543210  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
113240971  cytochrome P450 1A2 isoform X2 [KO:K07409] [EC:1.14.14.1]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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