KEGG   PATHWAY: vcan04013
Entry
vcan04013                   Pathway                                
Name
MAPK signaling pathway - fly - Venturia canescens
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
vcan04013  MAPK signaling pathway - fly
vcan04013

Other DBs
GO: 0000165
Organism
Venturia canescens [GN:vcan]
Gene
122419193  torso-like protein [KO:K12377]
122416976  torso-like protein [KO:K12377]
122417746  torso-like protein [KO:K12377]
122418091  torso-like protein isoform X1 [KO:K12377]
122412969  torso-like protein [KO:K12377]
122406385  torso-like protein isoform X1 [KO:K12377]
122406601  torso-like protein [KO:K12377]
122407781  torso-like protein [KO:K12377]
122412083  protein giant-lens [KO:K02104]
122412601  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122412218  leucine-rich repeat-containing protein 24-like [KO:K20230]
122413064  proto-oncogene tyrosine-protein kinase ROS isoform X1 [KO:K05088] [EC:2.7.10.1]
122415460  SHC-transforming protein 1 [KO:K06279]
122413698  growth factor receptor-bound protein 2 [KO:K04364]
122419128  GRB2-associated-binding protein 2 [KO:K20231]
122418422  tyrosine-protein phosphatase corkscrew-like isoform X1 [KO:K07293] [EC:3.1.3.48]
122418940  protein son of sevenless [KO:K03099]
122413172  ras-like protein 1 [KO:K07827]
122413171  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
122417704  ras GTPase-activating protein 3 isoform X1 [KO:K12380]
122411710  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
122415758  14-3-3 protein zeta isoform X1 [KO:K16197]
122411524  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122409436  kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
122414907  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
122412584  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122408913  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
122408774  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
122417671  importin-7 [KO:K20223]
122416585  nuclear receptor subfamily 2 group E member 1 [KO:K08545]
122406061  nuclear receptor subfamily 2 group E member 1 [KO:K08545]
122412171  protein groucho-like isoform X1 [KO:K04497]
122412175  protein groucho-like isoform X1 [KO:K04497]
122411852  protein groucho isoform X1 [KO:K04497]
122405948  zinc finger protein mnm-2-like [KO:K12379]
122410699  ETS-like protein pointed isoform X1 [KO:K02678]
122406090  ets DNA-binding protein pokkuri [KO:K03211]
122412530  exportin-1 [KO:K14290]
122414654  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
122413605  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
122407839  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
122405832  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
122408907  homeobox protein prospero isoform X1 [KO:K20211]
122405621  tyrosine-protein kinase Src42A [KO:K08892] [EC:2.7.10.2]
122418491  tyrosine-protein kinase Src64B isoform X1 [KO:K05704] [EC:2.7.10.2]
122407193  tyrosine-protein kinase Btk29A isoform X1 [KO:K07364] [EC:2.7.10.2]
122410434  tyrosine-protein kinase Shark [KO:K17512] [EC:2.7.10.2]
122408008  serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]
122419279  ras-related protein Rac1 [KO:K04392]
122409245  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
122411682  ras-like GTP-binding protein RhoL [KO:K04392]
122405899  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
122415725  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
122415661  mitogen-activated protein kinase kinase kinase 10-like isoform X1 [KO:K04417] [EC:2.7.11.25]
122414246  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
122409733  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
122410864  serine/threonine-protein kinase 10-like [KO:K04431] [EC:2.7.12.2]
122415166  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122411239  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
122416846  striatin-3 isoform X1 [KO:K17608]
122415950  transcription factor AP-1 [KO:K04448]
122417112  protein decapentaplegic-like [KO:K04662]
122410853  profilin [KO:K05759]
122411814  uncharacterized protein LOC122411814 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122413068  bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
122419522  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122410990  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
122415152  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]
122415552  mitogen-activated protein kinase p38b-like isoform X1 [KO:K04441] [EC:2.7.11.24]
122417859  cyclic AMP-dependent transcription factor ATF-7 isoform X1 [KO:K04450]
122414533  dual oxidase isoform X1 [KO:K13411] [EC:1.6.3.1 1.11.1.-]
122417176  optomotor-blind protein isoform X1 [KO:K10176]
122413792  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
122413126  superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
vcan04214  Apoptosis - fly
KO pathway
ko04013   
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