KEGG   PATHWAY: vfu00260
Entry
vfu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio furnissii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vfu00260  Glycine, serine and threonine metabolism
vfu00260

Module
vfu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vfu00260]
vfu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vfu00260]
vfu_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:vfu00260]
vfu_M00555  Betaine biosynthesis, choline => betaine [PATH:vfu00260]
vfu_M00621  Glycine cleavage system [PATH:vfu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio furnissii [GN:vfu]
Gene
vfu_A03126  aspartate kinase III [KO:K00928] [EC:2.7.2.4]
vfu_A02976  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
vfu_B00640  aspartate kinase [KO:K00928] [EC:2.7.2.4]
vfu_A02897  bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
vfu_A00581  aspartokinase II/homoserine dehydrogenase, methionine-sensitive [KO:K12525] [EC:2.7.2.4 1.1.1.3]
vfu_A01216  aspartate-semialdehyde dehydrogenase, hypothetical [KO:K00133] [EC:1.2.1.11]
vfu_A01293  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
vfu_A02896  homoserine kinase [KO:K00872] [EC:2.7.1.39]
vfu_A02895  threonine synthase [KO:K01733] [EC:4.2.3.1]
vfu_B01400  L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
vfu_A02660  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
vfu_B01364  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
vfu_A03125  aminotransferase, class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
vfu_A00756  2-hydroxyacid dehydrogenase family protein [KO:K00018] [EC:1.1.1.29]
vfu_B00592  Lactate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
vfu_B01214  glycerate kinase [KO:K00865] [EC:2.7.1.165]
vfu_B00588  glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
vfu_A00030  phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
vfu_B00089  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
vfu_A00816  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
vfu_A02295  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
vfu_A02875  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
vfu_B00563  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
vfu_B00562  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
vfu_B01361  glycine cleavage system P protein [KO:K00281] [EC:1.4.4.2]
vfu_B01366  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
vfu_B00911  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
vfu_A00882  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
vfu_A00050  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
vfu_A00378  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
vfu_A00380  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
vfu_B00942  Monomeric sarcosine oxidase (MSOX) [KO:K00301] [EC:1.5.3.1]
vfu_A01777  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
vfu_A02443  L-serine deaminase [KO:K01752] [EC:4.3.1.17]
vfu_A00292  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
vfu_B00821  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
vfu_A02214  amino acid aldolase or racemase [KO:K01753] [EC:4.3.1.18]
vfu_B00460  alanine racemase [KO:K25317] [EC:5.1.1.10]
vfu_A02223  intracellular septation protein A [KO:K01695] [EC:4.2.1.20]
vfu_A02222  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
vfu_A01724  aminotransferase, class III/decarboxylase, group II [KO:K00836] [EC:2.6.1.76]
vfu_B00642  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
vfu_B00643  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
vfu_B00641  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vfu00010  Glycolysis / Gluconeogenesis
vfu00020  Citrate cycle (TCA cycle)
vfu00230  Purine metabolism
vfu00250  Alanine, aspartate and glutamate metabolism
vfu00270  Cysteine and methionine metabolism
vfu00290  Valine, leucine and isoleucine biosynthesis
vfu00300  Lysine biosynthesis
vfu00330  Arginine and proline metabolism
vfu00460  Cyanoamino acid metabolism
vfu00470  D-Amino acid metabolism
vfu00564  Glycerophospholipid metabolism
vfu00600  Sphingolipid metabolism
vfu00620  Pyruvate metabolism
vfu00630  Glyoxylate and dicarboxylate metabolism
vfu00640  Propanoate metabolism
vfu00680  Methane metabolism
vfu00860  Porphyrin metabolism
vfu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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