Entry
Name
Notch signaling pathway - Xiphias gladius (swordfish)
Description
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Xiphias gladius (swordfish) [GN:
xgl ]
Gene
120804884 neurogenic locus notch homolog protein 1-like isoform X1 [KO:K02599 ]
120790638 notch2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994 ]
120806931 notch3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995 ]
120797567 rbpjb; recombination signal binding protein for immunoglobulin kappa J region b isoform X1 [KO:K06053 ]
120800333 rbpja; recombination signal binding protein for immunoglobulin kappa J region a [KO:K06053 ]
120783232 rbpjl; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053 ]
120786104 hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091 ]
120786581 heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091 ]
120788885 hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091 ]
120783705 hairy/enhancer-of-split related with YRPW motif protein 1-like [KO:K09091 ]
120806070 nrarpa; notch-regulated ankyrin repeat-containing protein A [KO:K26480 ]
120797479 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
120803573 segment polarity protein dishevelled homolog DVL-1-like [KO:K02353 ]
120799136 segment polarity protein dishevelled homolog DVL-3-like [KO:K02353 ]
120793534 tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497 ]
120790608 tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497 ]
120790739 tle3b; transducin-like enhancer protein 3-B isoform X1 [KO:K04497 ]
120783466 si:ch1073-335m2.2; msx2-interacting protein isoform X1 [KO:K25100 ]
Compound
C22528 Notch intracellular domain
Reference
Authors
Hansson EM, Lendahl U, Chapman G.
Title
Notch signaling in development and disease.
Journal
Reference
Authors
Callahan R, Egan SE.
Title
Notch signaling in mammary development and oncogenesis.
Journal
Reference
Authors
Zweidler-McKay PA, Pear WS.
Title
Notch and T cell malignancy.
Journal
Reference
Authors
Wu L, Griffin JD.
Title
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
Journal
Reference
Authors
Tsukumo S, Yasutomo K.
Title
Notch governing mature T cell differentiation.
Journal
Reference
Authors
Haltiwanger RS.
Title
Regulation of signal transduction pathways in development by glycosylation.
Journal
Reference
Authors
Koo EH, Kopan R.
Title
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.
Journal
Reference
Authors
Okano H, Imai T, Okabe M.
Title
Musashi: a translational regulator of cell fate.
Journal
J Cell Sci 115:1355-9 (2002)
Reference
Authors
Haltiwanger RS, Stanley P.
Title
Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
Journal
Reference
Authors
Das G, Reynolds-Kenneally J, Mlodzik M.
Title
The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.
Journal
Reference
Authors
Cooper MT, Bray SJ.
Title
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.
Journal
Reference
Authors
Tanigaki K, Kuroda K, Han H, Honjo T.
Title
Regulation of B cell development by Notch/RBP-J signaling.
Journal
Related pathway
KO pathway
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