KEGG   PATHWAY: yli00260
Entry
yli00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yarrowia lipolytica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
yli00260  Glycine, serine and threonine metabolism
yli00260

Module
yli_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:yli00260]
yli_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:yli00260]
yli_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:yli00260]
yli_M00621  Glycine cleavage system [PATH:yli00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yarrowia lipolytica [GN:yli]
Gene
2910365  YALI2_D00879g; Aspartokinase [KO:K00928] [EC:2.7.2.4]
2910253  YALI2_D00843g; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
2910416  YALI2_D01103g; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
2907881  YALI2_F00268g; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
2908784  YALI2_E01055g; Threonine synthase [KO:K01733] [EC:4.2.3.1]
2906427  YALI2_A00341g; Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
2910775  YALI2_D00470g; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
2911591  YALI2_E01433g; Serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
2911630  YALI2_E00330g; Alanine--glyoxylate aminotransferase 1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
2907141  YALI2_B00050g; Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
2905739  YALI2_A00646g; D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
2908991  YALI2_F00781g; D-3-phosphoglycerate dehydrogenase 1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
2908388  YALI2_F00856g; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
2906633  YALI2_C00671g; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
2910028  YALI2_C01052g; NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
2909236  YALI2_C00102g; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
2906052  YALI2_A00255g; Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
2909556  YALI2_B00448g; Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
2909633  YALI2_B00296g; Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
2905991  YALI2_A00154g; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
2907779  YALI2_F00053g; Putative aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
2910150  YALI2_D00728g; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
2912864  YALI2_E00007g; Glycine cleavage system H protein [KO:K02437]
2909003  YALI2_F00777g; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
2911832  YALI2_E01352g; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
2907652  YALI2_E00907g; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
2907946  YALI2_E00856g; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
2910708  YALI2_D00162g; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
2912520  YALI2_E00190g; Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
2908468  YALI2_F00114g; Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
2910530  YALI2_D01079g; Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
2906629  YALI2_C00759g; Catabolic L-serine/threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
2912595  YALI2_E01553g; Serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
2910167  YALI2_D00812g; D-serine dehydratase [KO:K20498] [EC:4.3.1.18]
2908896  YALI2_E01010g; Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
yli00010  Glycolysis / Gluconeogenesis
yli00020  Citrate cycle (TCA cycle)
yli00230  Purine metabolism
yli00250  Alanine, aspartate and glutamate metabolism
yli00270  Cysteine and methionine metabolism
yli00290  Valine, leucine and isoleucine biosynthesis
yli00300  Lysine biosynthesis
yli00330  Arginine and proline metabolism
yli00460  Cyanoamino acid metabolism
yli00470  D-Amino acid metabolism
yli00564  Glycerophospholipid metabolism
yli00600  Sphingolipid metabolism
yli00620  Pyruvate metabolism
yli00630  Glyoxylate and dicarboxylate metabolism
yli00640  Propanoate metabolism
yli00680  Methane metabolism
yli00860  Porphyrin metabolism
yli00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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