Entry Name Nucleotide excision repair - Paramormyrops kingsleyae
Description Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class Genetic Information Processing; Replication and repairBRITE hierarchy
Pathway map Other DBs Organism Paramormyrops kingsleyae [GN:
pki ]
Gene 111836202 ercc4; DNA repair endonuclease XPF isoform X1 [KO:K10848 ] [EC:3.1.-.-]
111840640 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843 ] [EC:5.6.2.4 ]
111842787 rpa3; replication protein A 14 kDa subunit isoform X1 [KO:K10740 ]
111844110 ercc2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844 ] [EC:5.6.2.3 ]
111845231 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014 ]
111847194 rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
111847866 polr2j; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008 ]
111847969 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007 ]
111848282 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009 ]
111850286 gtf2h2c; general transcription factor IIH subunit 2-like protein [KO:K03142 ]
111850575 gtf2h3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143 ]
111850639 polr2i; DNA-directed RNA polymerase II subunit RPB9 isoform X1 [KO:K03017 ]
111851053 mnat1; CDK-activating kinase assembly factor MAT1 isoform X1 [KO:K10842 ]
111851938 polr2c; DNA-directed RNA polymerase II subunit RPB3 isoform X1 [KO:K03011 ]
111853565 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016 ]
111855397 xpa; DNA repair protein complementing XP-A cells isoform X1 [KO:K10847 ]
111855826 ercc5; DNA repair protein complementing XP-G cells isoform X1 [KO:K10846 ]
111855834 xpc; DNA repair protein complementing XP-C cells isoform X1 [KO:K10838 ]
Reference Authors Sugasawa K.
Title [Molecular mechanism of mammalian nucleotide excision repair]
Journal Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference Authors Nakatsu Y.
Title [Transcription-coupled repair and Cockayne syndrome]
Journal Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference Authors Nakagawa N, Masui R, Kuramitsu S.
Title [Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
Journal Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference Authors Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Title Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Journal Reference Authors Saldivar JS, Wu X, Follen M, Gershenson D.
Title Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Journal Reference Authors Sugasawa K.
Title [DNA repair pathways involving Cul4A ubiquitin ligases]
Journal Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference Authors Ito S, Ando D, Tanaka K.
Title [Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
Journal Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related KO pathway
