KEGG   PATHWAY: ppad03015
Entry
ppad03015                   Pathway                                
Name
mRNA surveillance pathway - Panthera pardus (leopard)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
ppad03015  mRNA surveillance pathway
ppad03015

Other DBs
GO: 0071028
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109270109  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
109264016  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
109250760  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
109259164  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
109266854  MAGOH; protein mago nashi homolog [KO:K12877]
109268595  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
109247441  CASC3; protein CASC3 isoform X1 [KO:K14323]
109276816  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109266179  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
109253294  PNN; pinin [KO:K13114]
109255034  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
109278159  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
109276767  ALYREF; THO complex subunit 4 [KO:K12881]
109270638  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
109270639  ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
109261858  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
109250067  GLE1; nucleoporin GLE1 [KO:K18723]
109246606  NXF1; nuclear RNA export factor 1 [KO:K14284]
109261037  nuclear RNA export factor 2-like [KO:K14284]
109260347  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
109260364  nuclear RNA export factor 2-like [KO:K14284]
109274648  NXT1; NTF2-related export protein 1 [KO:K14285]
109253664  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
109260530  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
109270304  PYM1; partner of Y14 and mago [KO:K14294]
109274321  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
109263391  RNGTT; mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
109257630  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
109259028  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
109274101  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
109245726  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
109255027  polyadenylate-binding protein 2 [KO:K14396]
109270894  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
109246543  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
109270488  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
109274535  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
109251159  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
109255018  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
109246457  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
109267283  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
109258314  CPSF1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
109274473  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
109268842  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
109277006  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404]
109251234  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
109279070  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
109278808  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
109247898  WDR82; WD repeat-containing protein 82 [KO:K14962]
109266491  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109246846  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109277658  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109273939  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
109272233  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
109258844  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
109255411  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
109271317  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
109253209  SYMPK; symplekin isoform X1 [KO:K06100]
109247222  RNA-binding protein Musashi homolog 2-like [KO:K14411]
109257683  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
109247467  RNA-binding protein Musashi homolog 2-like [KO:K14411]
109277538  MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
109255459  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
109249317  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
109272388  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
109257553  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
109260318  polyadenylate-binding protein 1-like 2 [KO:K13126]
109260319  PABPC1L2A; polyadenylate-binding protein 1-like 2 [KO:K13126]
109278007  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
109252136  ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
109278338  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
109261041  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
109247642  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
109273732  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
109278389  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
109253890  SMG7; protein SMG7 isoform X1 [KO:K14409]
109256286  SMG5; protein SMG5 isoform X1 [KO:K11125]
109255124  telomerase-binding protein EST1A-like isoform X1 [KO:K11124] [EC:3.1.-.-]
109255128  telomerase-binding protein EST1A [KO:K11124] [EC:3.1.-.-]
109250803  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
109277271  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109278670  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
109252915  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
109246311  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
109256720  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
109277309  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
109269702  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
109259570  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
109253325  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
109256152  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
109271642  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
109268349  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
109246690  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
109254718  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
109274569  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
109249895  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
109275895  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
ppad03013  Nucleocytoplasmic transport
ppad03018  RNA degradation
ppad03040  Spliceosome
KO pathway
ko03015   
LinkDB

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