KEGG   PATHWAY: psc00260
Entry
psc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Stutzerimonas stutzeri CCUG 29243
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psc00260  Glycine, serine and threonine metabolism
psc00260

Module
psc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psc00260]
psc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psc00260]
psc_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:psc00260]
psc_M00555  Betaine biosynthesis, choline => betaine [PATH:psc00260]
psc_M00621  Glycine cleavage system [PATH:psc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Stutzerimonas stutzeri CCUG 29243 [GN:psc]
Gene
A458_20395  aspartate kinase [KO:K00928] [EC:2.7.2.4]
A458_07305  aspartate kinase [KO:K00928] [EC:2.7.2.4]
A458_11900  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A458_15760  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
A458_20770  homoserine kinase [KO:K02204] [EC:2.7.1.39]
A458_15065  thrH; phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
A458_10660  thrH; phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
A458_15755  threonine synthase [KO:K01733] [EC:4.2.3.1]
A458_07295  threonine aldolase [KO:K01620] [EC:4.1.2.48]
A458_11830  threonine aldolase [KO:K01620] [EC:4.1.2.48]
A458_17065  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A458_16165  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
A458_08520  putative 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
A458_05080  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
A458_00870  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
A458_19385  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A458_12410  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
A458_10420  hypothetical protein [KO:K00831] [EC:2.6.1.52]
A458_02490  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
A458_00970  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
A458_00960  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
A458_11460  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
A458_00965  glycine cleavage system protein H [KO:K02437]
A458_20500  glycine cleavage system H protein [KO:K02437]
A458_04405  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
A458_12050  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
A458_12055  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A458_03660  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
A458_19350  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A458_00360  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
A458_00365  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A458_12065  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A458_20380  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
A458_20375  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
A458_20385  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
A458_20390  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
A458_02990  tyrosine decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psc00010  Glycolysis / Gluconeogenesis
psc00020  Citrate cycle (TCA cycle)
psc00230  Purine metabolism
psc00250  Alanine, aspartate and glutamate metabolism
psc00270  Cysteine and methionine metabolism
psc00290  Valine, leucine and isoleucine biosynthesis
psc00300  Lysine biosynthesis
psc00330  Arginine and proline metabolism
psc00460  Cyanoamino acid metabolism
psc00470  D-Amino acid metabolism
psc00564  Glycerophospholipid metabolism
psc00620  Pyruvate metabolism
psc00630  Glyoxylate and dicarboxylate metabolism
psc00640  Propanoate metabolism
psc00680  Methane metabolism
psc00860  Porphyrin metabolism
psc00920  Sulfur metabolism
KO pathway
ko00260   
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