KEGG   PATHWAY: psen00260
Entry
psen00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudoalteromonas sp. NC201
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psen00260  Glycine, serine and threonine metabolism
psen00260

Module
psen_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psen00260]
psen_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psen00260]
psen_M00555  Betaine biosynthesis, choline => betaine [PATH:psen00260]
psen_M00621  Glycine cleavage system [PATH:psen00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudoalteromonas sp. NC201 [GN:psen]
Gene
PNC201_01245  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
PNC201_03795  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PNC201_03850  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PNC201_04280  gcvT2; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PNC201_04285  gcvH; Glycine cleavage system H protein [KO:K02437]
PNC201_04290  gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
PNC201_05485  asd1; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
PNC201_06160  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
PNC201_07245  lysC1; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
PNC201_09070  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
PNC201_09420  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
PNC201_09780  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
PNC201_09785  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PNC201_10885  cbs; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
PNC201_12420  ghrA; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PNC201_12890  lysC2; Aspartokinase 2 [KO:K00928] [EC:2.7.2.4]
PNC201_13375  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PNC201_13380  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
PNC201_13385  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
PNC201_13390  thrA; Bifunctional aspartokinase/homoserine dehydrogenase 1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
PNC201_13695  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PNC201_13770  [KO:K00018] [EC:1.1.1.29]
PNC201_14480  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
PNC201_14485  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
PNC201_14790  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PNC201_16190  metL; Bifunctional aspartokinase/homoserine dehydrogenase 2 [KO:K12525] [EC:2.7.2.4 1.1.1.3]
PNC201_18000  [KO:K15918] [EC:2.7.1.31]
PNC201_19440  asd2; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PNC201_19700  betB; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PNC201_19705  betA; Oxygen-dependent choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PNC201_20110  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PNC201_21805  [KO:K25316]
PNC201_22710  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psen00010  Glycolysis / Gluconeogenesis
psen00020  Citrate cycle (TCA cycle)
psen00230  Purine metabolism
psen00250  Alanine, aspartate and glutamate metabolism
psen00270  Cysteine and methionine metabolism
psen00290  Valine, leucine and isoleucine biosynthesis
psen00300  Lysine biosynthesis
psen00330  Arginine and proline metabolism
psen00460  Cyanoamino acid metabolism
psen00470  D-Amino acid metabolism
psen00564  Glycerophospholipid metabolism
psen00600  Sphingolipid metabolism
psen00620  Pyruvate metabolism
psen00630  Glyoxylate and dicarboxylate metabolism
psen00640  Propanoate metabolism
psen00680  Methane metabolism
psen00860  Porphyrin metabolism
psen00920  Sulfur metabolism
KO pathway
ko00260   

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