KEGG   PATHWAY: psom00480
Entry
psom00480                   Pathway                                
Name
Glutathione metabolism - Papaver somniferum (opium poppy)
Class
Metabolism; Metabolism of other amino acids
Pathway map
psom00480  Glutathione metabolism
psom00480

Module
psom_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:psom00480]
Other DBs
GO: 0006749
Organism
Papaver somniferum (opium poppy) [GN:psom]
Gene
113339244  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113353554  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113348072  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113354039  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113349296  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113300000  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
113346330  gamma-glutamylcyclotransferase 2-3-like [KO:K22596] [EC:4.3.2.9]
113356209  gamma-glutamylcyclotransferase 2-3-like [KO:K22596] [EC:4.3.2.9]
113358780  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
113282439  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
113276469  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
113283164  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
113296928  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
113315065  glutathione synthetase, chloroplastic-like isoform X1 [KO:K21456] [EC:6.3.2.3]
113350147  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
113330796  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
113299153  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
113299090  puromycin-sensitive aminopeptidase-like isoform X1 [KO:K01256] [EC:3.4.11.2]
113317316  puromycin-sensitive aminopeptidase-like isoform X1 [KO:K01256] [EC:3.4.11.2]
113350463  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
113347731  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
113305056  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113306551  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113308493  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113309905  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113319096  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113301858  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113304443  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113295418  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113334981  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113298287  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113322335  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113328952  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113330093  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113309180  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113274958  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113274959  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113274960  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113274962  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113274963  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113336226  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113271772  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113274404  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
113279055  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113279072  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113300992  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113306624  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
113303227  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113304504  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113304505  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113304506  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113304508  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113326538  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113307535  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113311347  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113272056  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113328345  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113334359  glutathione S-transferase F13-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113334400  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113331125  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
113324445  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113284070  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113286098  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
113345327  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113274006  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
113275403  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113277221  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113285849  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113290105  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113304509  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113291620  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
113294985  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113299808  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
113299809  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113316953  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113331347  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113311142  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113274800  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113335734  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113335772  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113277278  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113285461  glutathione S-transferase F13-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113287336  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113287337  probable glutathione S-transferase parC isoform X1 [KO:K00799] [EC:2.5.1.18]
113290164  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113290166  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113302733  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113289326  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113298967  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
113331457  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113302592  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113305254  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113306377  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
113306379  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
113317494  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113318969  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113318971  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113334931  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113272184  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113272185  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113318840  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113331494  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113322541  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113322542  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113342784  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113343186  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113343189  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113343227  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113286365  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113289971  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113344327  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113344505  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113345567  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113282212  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113343374  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113343379  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113277436  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
113303723  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113303724  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113286685  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113286686  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113359326  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113350236  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113351375  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113354171  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113349170  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113360964  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113360966  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113349584  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
113360311  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113359393  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
113356336  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
113357438  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
113354119  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113354123  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113348197  glutathione S-transferase F13-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113358728  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
113314260  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113322673  glutathione S-transferase DHAR2-like isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113322725  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113282063  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113310919  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113307676  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113275549  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113316540  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
113306731  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
113284112  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
113356125  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
113309939  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
113300069  isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
113318220  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
113289856  isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
113281904  6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113294600  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113275707  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113328170  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113278784  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113304626  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113281557  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113302640  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113276556  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113281005  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113271695  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113358055  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113316226  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
113300039  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
113301160  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
113301596  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
113304227  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
113284074  probable glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
113278373  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
113273619  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
113345163  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
113274608  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
113355303  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
113332656  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
113335174  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
113352994  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
113328939  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
113291591  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
113289037  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
113299132  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
113342144  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
113276420  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
113297918  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
113322813  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
113338425  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
113282498  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
113358461  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
113290889  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
113321825  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
113346337  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
113288942  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
113309651  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
113330609  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
113282817  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
113357184  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
113356406  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
113361130  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
113283524  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
113287118  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
113357203  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
113276634  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
113281533  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
113355342  ribonucleoside-diphosphate reductase small chain A-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
psom00220  Arginine biosynthesis
psom00250  Alanine, aspartate and glutamate metabolism
psom00270  Cysteine and methionine metabolism
psom00430  Taurine and hypotaurine metabolism
psom00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system