KEGG   PATHWAY: pvu00480
Entry
pvu00480                    Pathway                                
Name
Glutathione metabolism - Phaseolus vulgaris (common bean)
Class
Metabolism; Metabolism of other amino acids
Pathway map
pvu00480  Glutathione metabolism
pvu00480

Module
pvu_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:pvu00480]
Other DBs
GO: 0006749
Organism
Phaseolus vulgaris (common bean) [GN:pvu]
Gene
PHAVU_001G249200g  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
PHAVU_004G173700g  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
PHAVU_009G103300g  hypothetical protein [KO:K22596] [EC:4.3.2.9]
PHAVU_008G163900g  hypothetical protein [KO:K22596] [EC:4.3.2.9]
PHAVU_002G211700g  hypothetical protein [KO:K01469] [EC:3.5.2.9]
PHAVU_002G289200g  hypothetical protein [KO:K01919] [EC:6.3.2.2]
PHAVU_002G157600g  hypothetical protein [KO:K01919] [EC:6.3.2.2]
PHAVU_006G094500g  hypothetical protein [KO:K21456] [EC:6.3.2.3]
PHAVU_006G094700g  hypothetical protein [KO:K21456] [EC:6.3.2.3]
PHAVU_006G094600g  hypothetical protein [KO:K21456] [EC:6.3.2.3]
PHAVU_009G195000g  hypothetical protein [KO:K01255] [EC:3.4.11.1]
PHAVU_003G156100g  hypothetical protein [KO:K01255] [EC:3.4.11.1]
PHAVU_002G2910000  hypothetical protein [KO:K01256] [EC:3.4.11.2]
PHAVU_009G187800g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_010G074600g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_010G075400g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_011G178400g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G164900g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_006G079600g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G053100g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G053200g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G053300g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G053900g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G054000g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G054100g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_005G054200g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_003G071300g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G013200g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G107200g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_006G022600g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_006G023400g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_006G023500g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_008G113600g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_008G113700g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_003G123300g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_002G080100g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_002G080200g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_006G087500g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_001G002000g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_002G241400g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_002G288500g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_002G288600g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_008G241100g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_006G020800g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_008G195400g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_008G195500g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_008G195600g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_009G105900g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G250000g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G161900g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G162000g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_001G173300g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_001G173500g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G134700g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_007G1348001  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_010G074700g  hypothetical protein [KO:K00799] [EC:2.5.1.18]
PHAVU_001G230400g  hypothetical protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
PHAVU_007G009800g  hypothetical protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
PHAVU_007G177200g  hypothetical protein [KO:K00383] [EC:1.8.1.7]
PHAVU_004G083600g  hypothetical protein [KO:K00383] [EC:1.8.1.7]
PHAVU_004G011200g  hypothetical protein [KO:K00031] [EC:1.1.1.42]
PHAVU_008G239900g  hypothetical protein [KO:K00031] [EC:1.1.1.42]
PHAVU_005G043900g  hypothetical protein [KO:K00031] [EC:1.1.1.42]
PHAVU_008G023700g  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
PHAVU_002G295200g  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
PHAVU_002G295300g  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
PHAVU_004G046100g  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
PHAVU_010G143200g  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
PHAVU_004G0570001  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
PHAVU_004G0570000  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
PHAVU_001G223300g  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
PHAVU_008G148700g  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
PHAVU_008G016900g  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
PHAVU_001G041100g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_002G288700g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_002G288800g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_001G149000g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_002G157200g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_002G322400g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_L010600g  hypothetical protein [KO:K00432] [EC:1.11.1.9]
PHAVU_002G189300g  hypothetical protein [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
PHAVU_009G020400g  hypothetical protein [KO:K01581] [EC:4.1.1.17]
PHAVU_009G020500g  hypothetical protein [KO:K01581] [EC:4.1.1.17]
PHAVU_002G072200g  hypothetical protein [KO:K00797] [EC:2.5.1.16]
PHAVU_003G199000g  hypothetical protein [KO:K00797] [EC:2.5.1.16]
PHAVU_003G052600g  hypothetical protein [KO:K00797] [EC:2.5.1.16]
PHAVU_009G054800g  hypothetical protein [KO:K00797] [EC:2.5.1.16]
PHAVU_011G035000g  hypothetical protein [KO:K00434] [EC:1.11.1.11]
PHAVU_009G1265000  hypothetical protein [KO:K00434] [EC:1.11.1.11]
PHAVU_011G071300g  hypothetical protein [KO:K00434] [EC:1.11.1.11]
PHAVU_009G093000g  hypothetical protein [KO:K00434] [EC:1.11.1.11]
PHAVU_002G104700g  hypothetical protein [KO:K00434] [EC:1.11.1.11]
PHAVU_002G107000g  hypothetical protein [KO:K00434] [EC:1.11.1.11]
PHAVU_009G115100g  hypothetical protein [KO:K10807] [EC:1.17.4.1]
PHAVU_002G267900g  hypothetical protein [KO:K10807] [EC:1.17.4.1]
PHAVU_001G093300g  hypothetical protein [KO:K10808] [EC:1.17.4.1]
PHAVU_001G190100g  hypothetical protein [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
pvu00220  Arginine biosynthesis
pvu00250  Alanine, aspartate and glutamate metabolism
pvu00270  Cysteine and methionine metabolism
pvu00430  Taurine and hypotaurine metabolism
pvu00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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