 | | PATHWAY: rn00100 | |
| Entry |
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| Name |
Steroid biosynthesis |
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| Class |
Metabolism; Lipid metabolism
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| Pathway map |
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| Module |
| M00101 | Cholesterol biosynthesis, FPP => cholesterol [PATH:rn00100] |
| M00102 | Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol [PATH:rn00100] |
| M00917 | Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol [PATH:rn00100] |
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| Other DBs |
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| Reaction |
| R00702 | farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase |
| R01451 | cholesterol:NAD+ delta7-oxidoreductase |
| R01456 | cholesterol:NADP+ delta7-oxidoreductase |
| R01457 | cholesterol:NADP+ Delta24-oxidoreductase |
| R01461 | acyl-CoA:cholesterol O-acyltransferase |
| R01462 | cholesterol ester acylhydrolase |
| R02692 | 1,2-diacyl-sn-glycerol:sterol O-acyltransferase |
| R02872 | presqualene-diphosphate diphosphate-lyase (reducing, squalene-forming) |
| R02874 | squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing) |
| R03199 | (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming) |
| R03200 | (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming) |
| R03353 | 5alpha-cholest-7-en-3beta-ol delta7-delta8-isomerase |
| R03610 | calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating) |
| R03611 | calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating) |
| R03689 | lanosterol delta24-reductase |
| R03775 | cycloeucalenol lyase (cyclopropane-decyclizing) |
| R04427 | S-adenosyl-L-methionine:zymosterol C-methyltransferase |
| R04804 | delta8,24-cholestadien-3beta-ol delta7-delta8-isomerase |
| R05639 | 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase |
| R05640 | lanosterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) |
| R05641 | ergosterol:NADP+ Delta24(24(1))-oxidoreductase |
| R05703 | lanosterol D24-reductase |
| R05731 | obtusifoliol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) |
| R05776 | S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase |
| R07215 | lathosterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating |
| R07486 | delta7-avenasterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating |
| R07489 | beta-sitosterol,NADPH:oxygen oxidoreductase (22,23-dehydrogenating) |
| R07491 | episterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating |
| R07495 | 4alpha-methylzymosterol:NADP+ 3-oxidoreductase |
| R07506 | ergosta-5,7,24(28)-trien-3beta-ol,NADPH:oxygen oxidoreductase (22,23-dehydrogenating) |
| R07509 | 14-demethyllanosterol,ferrocytochrome-b5:oxygen oxidoreductase (hydroxylating) |
| R09515 | calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating) |
| R09516 | calcidiol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating) |
| R11097 | 24-epi-campesterol,NADPH:oxygen oxidoreductase (22,23-dehydrogenating) |
| R11458 | calciol,ferredoxin:oxygen oxidoreductase (1,25-hydroxylating) |
| R12323 | lanosterol,reduced ferredoxin:oxygen oxidoreductase (14-methyl cleaving) |
| R12371 | 3beta-hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate:NAD+ 3-oxidoreductase (decarboxylating) |
| R12375 | 3beta-hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate:NAD+ 3-oxidoreductase (decarboxylating) |
| R12376 | 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol:NAD+ 3-oxidoreductase (decarboxylating) |
| R12377 | 24-methylidenecycloartanol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating) |
| R12378 | 24-methylenelophenol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating) |
| R12379 | 24-ethylidenelophenol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating) |
| R12399 | cycloeucalenol:NADP+ 3-oxidoreductase |
| R12400 | episterol:NADP+ 3-oxidoreductase |
| R12401 | delta7-avenasterol:NADP+ 3-oxidoreductase |
| R12403 | 4alpha-methylzymosterol,ferrocytochrome-b5:oxygen oxidoreductase (hydroxylating) |
| R12404 | 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ 3-oxidoreductase (decarboxylating) |
| R12405 | zymosterol:NADP+ 3-oxidoreductase |
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| Compound |
| C00448 | trans,trans-Farnesyl diphosphate |
| C03428 | Presqualene diphosphate |
| C03845 | 5alpha-Cholest-8-en-3beta-ol |
| C05103 | 4alpha-Methylzymosterol |
| C05109 | 24,25-Dihydrolanosterol |
| C05439 | 5alpha-Cholesta-7,24-dien-3beta-ol |
| C05440 | Ergosta-5,7,22,24(28)-tetraen-3beta-ol |
| C08830 | 24-Methylidenecycloartanol |
| C11455 | 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol |
| C11508 | 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol |
| C15776 | 4alpha-Methylfecosterol |
| C15781 | 24-Methylenecholesterol |
| C15808 | 4alpha-Methylzymosterol-4-carboxylate |
| C15816 | 3-Keto-4-methylzymosterol |
| C15915 | 4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol |
| C22112 | 4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol |
| C22116 | 3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate |
| C22119 | 3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate |
| C22120 | 4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol |
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| Reference |
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| Authors |
Koshiba K, Kamiya Y. |
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| Title |
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese) |
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| Journal |
Koudansya saientific:199-138 (2002) |
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| Reference |
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| Authors |
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D. |
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| Title |
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. |
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| Journal |
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| Reference |
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| Authors |
Lange BM, Ghassemian M. |
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| Title |
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. |
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| Journal |
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Related
pathway |
| rn00120 | Primary bile acid biosynthesis |
| rn00140 | Steroid hormone biosynthesis |
| rn00900 | Terpenoid backbone biosynthesis |
| rn00905 | Brassinosteroid biosynthesis |
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| KO pathway |
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