 | | PATHWAY: ko00100 | |
| Entry |
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| Name |
Steroid biosynthesis |
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| Class |
Metabolism; Lipid metabolism
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| Pathway map |
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| Module |
| M00101 | Cholesterol biosynthesis, FPP => cholesterol [PATH:ko00100] |
| M00102 | Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol [PATH:ko00100] |
| M00917 | Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol [PATH:ko00100] |
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| Drug |
| D00282 | Clotrimazole (JP18/USP/INN) |
| D00322 | Fluconazole (JP18/USP/INN) |
| D00350 | Itraconazole (JP18/USP) |
| D00351 | Ketoconazole (JP18/USP) |
| D00381 | Tolnaftate (JP18/USP/INN) |
| D00416 | Miconazole (JP18/USP/INN) |
| D00578 | Voriconazole (JP18/USP/INN) |
| D00880 | Butoconazole nitrate (USP) |
| D00881 | Econazole nitrate (JAN/USP) |
| D00882 | Miconazole nitrate (JP18/USP) |
| D00883 | Naftifine hydrochloride (USP) |
| D00885 | Oxiconazole nitrate (JAN/USAN) |
| D00886 | Sulconazole nitrate (JAN/USP) |
| D00890 | Tioconazole (JAN/USP/INN) |
| D01092 | Lanoconazole (JP18/INN) |
| D01093 | Butenafine hydrochloride (JP18/USAN) |
| D01384 | Tolciclate (JAN/USAN/INN) |
| D01429 | Fosfluconazole (JAN/INN) |
| D01480 | Isoconazole nitrate (JAN) |
| D01620 | Neticonazole hydrochloride (JAN) |
| D01664 | Omoconazole nitrate (JAN/USAN) |
| D01720 | Amorolfine hydrochloride (JAN) |
| D01775 | Bifonazole (JP18/USAN/INN) |
| D02169 | Croconazole hydrochloride (JP18) |
| D02219 | Terbinafine hydrochloride (JP18/USP) |
| D02555 | Posaconazole (JAN/USAN/INN) |
| D02556 | Ravuconazole (prop.INN) |
| D02583 | Fenticonazole nitrate (USAN) |
| D06630 | Pramiconazole (USAN/INN) |
| D07676 | Chlormidazole hydrochloride |
| D11785 | Oteseconazole (USAN/INN) |
| D12326 | Opelconazole (USAN/INN) |
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| Other DBs |
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| Orthology |
| K23485 | alternative squalene epoxidase [EC:1.14.19.-] |
| K07748 | sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170] |
| K01052 | lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13] |
| K07438 | calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18] |
| K09829 | C-8 sterol isomerase [EC:5.-.-.-] |
| K23558 | plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase [EC:1.1.1.418] |
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| Compound |
| C00448 | trans,trans-Farnesyl diphosphate |
| C03428 | Presqualene diphosphate |
| C03845 | 5alpha-Cholest-8-en-3beta-ol |
| C05103 | 4alpha-Methylzymosterol |
| C05109 | 24,25-Dihydrolanosterol |
| C05439 | 5alpha-Cholesta-7,24-dien-3beta-ol |
| C05440 | Ergosta-5,7,22,24(28)-tetraen-3beta-ol |
| C08830 | 24-Methylidenecycloartanol |
| C11455 | 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol |
| C11508 | 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol |
| C15776 | 4alpha-Methylfecosterol |
| C15781 | 24-Methylenecholesterol |
| C15808 | 4alpha-Methylzymosterol-4-carboxylate |
| C15816 | 3-Keto-4-methylzymosterol |
| C15915 | 4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol |
| C22112 | 4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol |
| C22116 | 3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate |
| C22119 | 3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate |
| C22120 | 4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol |
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| Reference |
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| Authors |
Koshiba K, Kamiya Y. |
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| Title |
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese) |
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| Journal |
Koudansya saientific:199-138 (2002) |
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| Reference |
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| Authors |
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D. |
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| Title |
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. |
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| Journal |
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| Reference |
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| Authors |
Lange BM, Ghassemian M. |
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| Title |
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. |
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| Journal |
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Related
pathway |
| ko00120 | Primary bile acid biosynthesis |
| ko00140 | Steroid hormone biosynthesis |
| ko00900 | Terpenoid backbone biosynthesis |
| ko00905 | Brassinosteroid biosynthesis |
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| LinkDB |
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