KEGG   PATHWAY: ko00100
Entry
ko00100                     Pathway                                
Name
Steroid biosynthesis
Class
Metabolism; Lipid metabolism
Pathway map
ko00100  Steroid biosynthesis
ko00100

Module
M00101  Cholesterol biosynthesis, FPP => cholesterol [PATH:ko00100]
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol [PATH:ko00100]
M00103  Cholecalciferol biosynthesis [PATH:ko00100]
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol [PATH:ko00100]
Drug
D00282  Clotrimazole (JP18/USP/INN)
D00322  Fluconazole (JP18/USP/INN)
D00350  Itraconazole (JP18/USP)
D00351  Ketoconazole (JP18/USP)
D00381  Tolnaftate (JP18/USP/INN)
D00416  Miconazole (JP18/USP/INN)
D00578  Voriconazole (JP18/USP/INN)
D00880  Butoconazole nitrate (USP)
D00881  Econazole nitrate (JAN/USP)
D00882  Miconazole nitrate (JP18/USP)
D00883  Naftifine hydrochloride (USP)
D00885  Oxiconazole nitrate (JAN/USAN)
D00886  Sulconazole nitrate (JAN/USP)
D00888  Terconazole (USP/INN)
D00890  Tioconazole (JAN/USP/INN)
D01092  Lanoconazole (JP18/INN)
D01093  Butenafine hydrochloride (JP18/USAN)
D01384  Tolciclate (JAN/USAN/INN)
D01429  Fosfluconazole (JAN/INN)
D01480  Isoconazole nitrate (JAN)
D01550  Liranaftate (JAN/INN)
D01620  Neticonazole hydrochloride (JAN)
D01664  Omoconazole nitrate (JAN/USAN)
D01720  Amorolfine hydrochloride (JAN)
D01775  Bifonazole (JP18/USAN/INN)
D02169  Croconazole hydrochloride (JP18)
D02219  Terbinafine hydrochloride (JP18/USP)
D02375  Terbinafine (USAN/INN)
D02555  Posaconazole (JAN/USAN/INN)
D02556  Ravuconazole (prop.INN)
D02557  Chlormidazole (INN)
D02582  Fenticonazole (INN)
D02583  Fenticonazole nitrate (USAN)
D02584  Aliconazole (INN)
D02585  Vibunazole
D02923  Amorolfine (USAN/INN)
D03526  Cisconazole (USAN/INN)
D03936  Econazole (USAN/INN)
D04624  Isoconazole (USAN/INN)
D06630  Pramiconazole (USAN/INN)
D07596  Butenafine (INN)
D07598  Butoconazole (INN)
D07676  Chlormidazole hydrochloride
D07752  Croconazole (INN)
D08245  Naftifine (INN)
D08296  Omoconazole (INN)
D08313  Oxiconazole (INN)
D08535  Sulconazole (INN)
D11785  Oteseconazole (USAN/INN)
D12326  Opelconazole (USAN/INN)
Other DBs
GO: 0016126
Orthology
K00213  DHCR7; 7-dehydrocholesterol reductase [EC:1.3.1.21]
K00222  TM7SF2, ERG24; Delta14-sterol reductase [EC:1.3.1.70]
K00223  ERG4; Delta24(24(1))-sterol reductase [EC:1.3.1.71]
K00227  SC5DL, ERG3; Delta7-sterol 5-desaturase [EC:1.14.19.20]
K00511  SQLE, ERG1; squalene monooxygenase [EC:1.14.14.17]
K00559  SMT1, ERG6; sterol 24-C-methyltransferase [EC:2.1.1.41]
K00637  SOAT; sterol O-acyltransferase [EC:2.3.1.26]
K00801  FDFT1; farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
K01052  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13]
K01824  EBP; cholestenol Delta-isomerase [EC:5.3.3.5]
K01852  LSS, ERG7; lanosterol synthase [EC:5.4.99.7]
K01853  CAS1; cycloartenol synthase [EC:5.4.99.8]
K05917  CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]
K07419  CYP2R1; vitamin D 25-hydroxylase [EC:1.14.14.24]
K07436  CYP24A1; vitamin D3 24-hydroxylase [EC:1.14.15.16]
K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
K07748  NSDHL, ERG26; sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170]
K07750  MESO1, ERG25; methylsterol monooxygenase [EC:1.14.18.9]
K08242  E2.1.1.143; 24-methylenesterol C-methyltransferase [EC:2.1.1.143]
K08246  CPI1; cycloeucalenol cycloisomerase [EC:5.5.1.9]
K09827  ERG27; 3-keto steroid reductase [EC:1.1.1.270]
K09828  DHCR24, DWF1; Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-]
K09829  ERG2; C-8 sterol isomerase [EC:5.-.-.-]
K09831  ERG5, CYP61A; sterol 22-desaturase [EC:1.14.19.41]
K09832  CYP710A; sterol 22-desaturase [EC:1.14.19.41]
K12298  CEL; bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]
K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]
K14423  SMO1; plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase [EC:1.14.18.10]
K14424  SMO2; plant 4alpha-monomethylsterol monooxygenase [EC:1.14.18.11]
K14674  TGL4; TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
K19532  LBR; Delta14-sterol reductase (lamin-B receptor) [EC:1.3.1.70]
K21146  CYP105A1; vitamin D 1,25-hydroxylase [EC:1.14.15.22]
K23485  AltSQE; alternative squalene epoxidase
K23558  3BETAHSDD; plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase
Compound
C00187  Cholesterol
C00448  trans,trans-Farnesyl diphosphate
C00751  Squalene
C01054  (S)-2,3-Epoxysqualene
C01164  7-Dehydrocholesterol
C01189  Lathosterol
C01561  Calcidiol
C01673  Calcitriol
C01694  Ergosterol
C01724  Lanosterol
C01753  beta-Sitosterol
C01789  Campesterol
C01802  Desmosterol
C01902  Cycloartenol
C01943  Obtusifoliol
C02141  Cycloeucalenol
C02530  Cholesterol ester
C03428  Presqualene diphosphate
C03845  5alpha-Cholest-8-en-3beta-ol
C04525  Fecosterol
C05103  4alpha-Methylzymosterol
C05107  7-Dehydrodesmosterol
C05108  14-Demethyllanosterol
C05109  24,25-Dihydrolanosterol
C05437  Zymosterol
C05439  5alpha-Cholesta-7,24-dien-3beta-ol
C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C05441  Vitamin D2
C05442  Stigmasterol
C05443  Vitamin D3
C07712  Secalciferol
C08813  Brassicasterol
C08821  Isofucosterol
C08830  24-Methylidenecycloartanol
C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C15776  4alpha-Methylfecosterol
C15777  Episterol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C15808  4alpha-Methylzymosterol-4-carboxylate
C15816  3-Keto-4-methylzymosterol
C15915  4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol
C18231  Calcitetrol
C21106  24-epi-Campesterol
C22112  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol
C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
C22121  Cycloeucalenone
C22122  Episterone
C22123  Avenastenone
C22136  Zymosterone
Reference
  Authors
Koshiba K, Kamiya Y.
  Title
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese)
  Journal
Koudansya saientific:199-138 (2002)
Reference
PMID:16531502
  Authors
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D.
  Title
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
  Journal
Plant Cell 18:1008-22 (2006)
DOI:10.1105/tpc.105.036012
Reference
PMID:12777052
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702
Related
pathway
ko00120  Primary bile acid biosynthesis
ko00140  Steroid hormone biosynthesis
ko00900  Terpenoid backbone biosynthesis
ko00905  Brassinosteroid biosynthesis
ko00984  Steroid degradation

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