Entry |
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Name |
Novobiocin biosynthesis |
Class |
Metabolism; Biosynthesis of other secondary metabolites
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Pathway map |
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Other DBs |
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Reaction |
R00734 | L-tyrosine:2-oxoglutarate aminotransferase |
R01728 | prephenate:NAD+ oxidoreductase(decarboxylating) |
R06746 | L-proline:[peptidyl-carrier protein] ligase (AMP-forming) |
R06747 | L-prolyl-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase |
R06748 | pyrrole-2-carbonyl-[peptidyl-carrier protein]:[peptidyl-carrier protein] (pyrrole-2-carbonyl)transferase |
R06757 | dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase |
R06758 | 3-(4-hydroxy-3-prenylphenyl)pyruvate:oxygen 1,2-oxidoreductase (4-hydroxy-3-prenylmandelate-forming) |
R06759 | 4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming) |
R06770 | dTDP-4-O-demethyl-beta-L-noviose:novobiocic-acid 7-O-[4-O-demethyl-L-noviosyl]transferase |
R06771 | S-adenosyl-L-methionine:demethyldecarbamoylnovobiocin 4''-O-methyltransferase |
R06772 | carbamoyl phosphate:decarbamoylnovobiocin 3''-O-carbamoyltransferase |
R10453 | 3-dimethylallyl-4-hydroxybenzoate:3-amino-4,7-dihydroxycoumarin ligase (AMP-forming) |
R10454 | S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase |
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Compound |
C01179 | 3-(4-Hydroxyphenyl)pyruvate |
C12456 | 3-Dimethylallyl-4-hydroxyphenylpyruvate |
C12457 | 3-Dimethylallyl-4-hydroxymandelic acid |
C12458 | 3-Dimethylallyl-4-hydroxybenzoate |
C12459 | 3-Dimethylallyl-4-hydroxybenzaldehyde |
C12460 | 3-Dimethylallyl-beta-hydroxy-L-tyrosyl-[pcp] |
C12462 | beta-Hydroxy-L-tyrosyl-[pcp] |
C12463 | beta-Keto-L-tyrosyl-[pcp] |
C12467 | 2-Hydroxy-beta-keto-L-tyrosyl-[pcp] |
C12468 | 3-Amino-4,7-dihydroxycoumarin |
C12469 | 3-Amino-4,7-dihydroxy-8-chlorocoumarin |
C12475 | Demethyldecarbamoylnovobiocin |
C12477 | 3-Methylpyrrole-2,4-dicarboxylic acid |
C12481 | dTDP-5-dimethyl-L-lyxose |
C12483 | Pyrrole-2-carbonyl-[pcp] |
C20629 | 8-Demethylnovobiocic acid |
C20637 | 5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate |
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Reference |
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Authors |
Pojer F, Li SM, Heide L. |
Title |
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. |
Journal |
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Reference |
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Authors |
Chen H, Walsh CT. |
Title |
Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI. |
Journal |
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Reference |
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Authors |
Schmutz E, Steffensky M, Schmidt J, Porzel A, Li SM, Heide L. |
Title |
An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. |
Journal |
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Reference |
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Authors |
Xu H, Kahlich R, Kammerer B, Heide L, Li SM. |
Title |
CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin. |
Journal |
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Reference |
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Authors |
Xu H, Wang ZX, Schmidt J, Heide L, Li SM. |
Title |
Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin. |
Journal |
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Reference |
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Authors |
Freel Meyers CL, Oberthur M, Xu H, Heide L, Kahne D, Walsh CT |
Title |
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. |
Journal |
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Reference |
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Authors |
Pojer F, Kahlich R, Kammerer B, Li SM, Heide L. |
Title |
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. |
Journal |
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Reference |
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Authors |
Li SM, Westrich L, Schmidt J, Kuhnt C, Heide L. |
Title |
Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments. |
Journal |
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Reference |
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Authors |
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L. |
Title |
CloQ, a prenyltransferase involved in clorobiocin biosynthesis. |
Journal |
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Related pathway |
rn00330 | Arginine and proline metabolism |
rn00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
rn00523 | Polyketide sugar unit biosynthesis |
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KO pathway |
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LinkDB |
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