Entry |
|
Name |
Novobiocin biosynthesis |
Class |
Metabolism; Biosynthesis of other secondary metabolites
|
Pathway map |
|
Other DBs |
|
Orthology |
K12701 | novobiocin biosynthesis protein NovH |
K12702 | novobiocin biosynthesis protein NovI |
K12703 | novobiocin biosynthesis protein NovJ |
K12704 | novobiocin biosynthesis protein NovK |
K12714 | clorobiocin biosynthesis protein Clo-hal |
K12720 | peptidyl carrier protein |
K12721 | L-prolyl-[peptidyl-carrier protein] dehydrogenase [EC:1.3.8.14] |
K12723 | clorobiocin biosynthesis protein CloN2 |
K17626 | clorobiocin biosynthesis protein CloN1 |
K12722 | clorobiocin/coumermycin A biosynthesis protein CloN6/CouN6 |
K12724 | clorobiocin/coumermycin A biosynthesis protein CloN7/CouN7 |
|
Compound |
C01179 | 3-(4-Hydroxyphenyl)pyruvate |
C12456 | 3-Dimethylallyl-4-hydroxyphenylpyruvate |
C12457 | 3-Dimethylallyl-4-hydroxymandelic acid |
C12458 | 3-Dimethylallyl-4-hydroxybenzoate |
C12459 | 3-Dimethylallyl-4-hydroxybenzaldehyde |
C12460 | 3-Dimethylallyl-beta-hydroxy-L-tyrosyl-[pcp] |
C12462 | beta-Hydroxy-L-tyrosyl-[pcp] |
C12463 | beta-Keto-L-tyrosyl-[pcp] |
C12467 | 2-Hydroxy-beta-keto-L-tyrosyl-[pcp] |
C12468 | 3-Amino-4,7-dihydroxycoumarin |
C12469 | 3-Amino-4,7-dihydroxy-8-chlorocoumarin |
C12475 | Demethyldecarbamoylnovobiocin |
C12477 | 3-Methylpyrrole-2,4-dicarboxylic acid |
C12481 | dTDP-5-dimethyl-L-lyxose |
C12483 | Pyrrole-2-carbonyl-[pcp] |
C20629 | 8-Demethylnovobiocic acid |
C20637 | 5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate |
|
Reference |
|
Authors |
Pojer F, Li SM, Heide L. |
Title |
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. |
Journal |
|
Reference |
|
Authors |
Chen H, Walsh CT. |
Title |
Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI. |
Journal |
|
Reference |
|
Authors |
Schmutz E, Steffensky M, Schmidt J, Porzel A, Li SM, Heide L. |
Title |
An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. |
Journal |
|
Reference |
|
Authors |
Xu H, Kahlich R, Kammerer B, Heide L, Li SM. |
Title |
CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin. |
Journal |
|
Reference |
|
Authors |
Xu H, Wang ZX, Schmidt J, Heide L, Li SM. |
Title |
Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin. |
Journal |
|
Reference |
|
Authors |
Freel Meyers CL, Oberthur M, Xu H, Heide L, Kahne D, Walsh CT |
Title |
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. |
Journal |
|
Reference |
|
Authors |
Pojer F, Kahlich R, Kammerer B, Li SM, Heide L. |
Title |
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. |
Journal |
|
Reference |
|
Authors |
Li SM, Westrich L, Schmidt J, Kuhnt C, Heide L. |
Title |
Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments. |
Journal |
|
Reference |
|
Authors |
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L. |
Title |
CloQ, a prenyltransferase involved in clorobiocin biosynthesis. |
Journal |
|
Related pathway |
ko00330 | Arginine and proline metabolism |
ko00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
ko00523 | Polyketide sugar unit biosynthesis |
|
LinkDB |
|