KEGG   PATHWAY: rn00330
Entry
rn00330                     Pathway                                
Name
Arginine and proline metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
rn00330  Arginine and proline metabolism
rn00330

Module
M00015  Proline biosynthesis, glutamate => proline [PATH:rn00330]
M00047  Creatine pathway [PATH:rn00330]
M00133  Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:rn00330]
M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:rn00330]
M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:rn00330]
M00136  GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:rn00330]
M00879  Arginine succinyltransferase pathway, arginine => glutamate [PATH:rn00330]
Other DBs
GO: 0006525 0006560
Reaction
R00111  N-(omega)-Hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
R00135   
R00178  S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylsulfanyl)propylamine-forming]
R00239  ATP:L-glutamate 5-phosphotransferase
R00245  L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
R00411  N-succinyl-L-glutamate amidohydrolase
R00471  4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
R00551  L-Arginine amidinohydrolase
R00554  ATP:L-arginine Nomega-phosphotransferase
R00558  L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)
R00559  L-Arginine:oxygen 2-oxidoreductase (decarboxylating)
R00562  N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)
R00563  N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)
R00565  L-Arginine:glycine amidinotransferase
R00566  L-arginine carboxy-lyase (agmatine-forming)
R00667  L-Ornithine:2-oxo-acid aminotransferase
R00670  L-ornithine carboxy-lyase (putrescine-forming)
R00671  L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
R00707  (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase
R00708  (S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase
R00832  succinyl-CoA:L-arginine N2-succinyltransferase
R01151  Putrescine:oxygen oxidoreductase (deaminating)
R01152  N-Carbamoylputrescine amidohydrolase
R01154  acetyl-CoA:putrescine N-acetyltransferase
R01155  putrescine:2-oxoglutarate aminotransferase
R01156  N-Acetylputrescine acetylhydrolase
R01157  Agmatine amidinohydrolase
R01246  L-proline:NAD+ 2-oxidoreductase
R01248  L-Proline:NAD+ 5-oxidoreductase
R01249  L-proline:NADP+ 2-oxidoreductase
R01251  L-Proline:NADP+ 5-oxidoreductase
R01252  L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
R01253  L-proline:quinone oxidoreductase
R01255  proline racemase
R01416  Agmatine iminohydrolase
R01563  N-Carbamoylsarcosine amidohydrolase
R01566  Creatine amidinohydrolase
R01617  4-Coumaroyl-CoA:agmatine N4-coumaroyltransferase
R01881  ATP:creatine N-phosphotransferase
R01883  S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
R01884  Creatinine amidohydrolase
R01914  spermidine:(acceptor) oxidoreductase
R01915  Spermidine:(acceptor) oxidoreductase
R01920  S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
R01986  4-Aminobutyraldehyde:NAD+ oxidoreductase
R01987  4-acetamidobutanoate amidohydrolase
R01989  L-Arginine:4-aminobutanoate amidinotransferase
R01990  4-Guanidinobutanoate amidinohydrolase
R01991  L-histidine:4-aminobutanoate ligase (ADP-forming)
R01992  alpha-Aminobutyryl histidine hydrolase
R02549  4-aminobutanal:NAD+ 1-oxidoreductase
R02575  ATP:guanidoacetate N-phosphotransferase
R02825   
R02869  S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
R02894  D-Proline:oxygen oxidoreductase
R02922  Creatinine iminohydrolase
R03177  4-Guanidinobutanal:NAD+ 1-oxidoreductase
R03178  2-oxo-5-Guanidinopentanoate carboxy-lyase
R03180  4-Guanidinobutanamide amidohydrolase
R03187  N-Methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)
R03249   
R03290  4-Hydroxy-L-proline:NAD+ oxidoreductase
R03291  trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
R03292  4-Hydroxy-L-proline:NADP+ oxidoreductase
R03293  trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase
R03295  trans-4-hydroxy-L-proline:quinone oxidoreductase
R03313  L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
R03314   
R04025  N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)
R04189  N2-succinyl-L-arginine iminohydrolase (decarboxylating)
R04217  N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase
R04374  trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
R04443   
R04444  L-1-pyrroline-3-hydroxy-5-carboxylate:NAD+ oxidoreductase
R04445  L-1-pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase
R05049  N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase
R05050  N4-Acetylaminobutanal:NAD+ oxidoreductase
R05051  L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase
R05052  L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase
R05053  D-aspartate:2-oxoglutarate aminotransferase
R07414  glutamate putrescine ligase
R07415   
R07417  4-(gamma-L-glutamylamino)butanal:NAD+ oxidoreductase
R07418  4-(gamma-L-glutamylamino)butanal:NADP+ oxidoreductase
R07419  4-(gamma-L-glutamylamino)butanoate amidohydrolase
R07420   
R08197  L-arginine:pyruvate aminotransferase
R08714  putrescine:pyruvate aminotransferase
R09076  spermidine:oxygen oxidoreductase (spermidine-forming)
R09077  spermidine:oxygen oxidoreductase (3-aminopropanal-forming)
R09079  carboxyspermidine:NADP+ oxidoreductase
R09080  carboxynorspermidine:NADP+ oxidoreductase
R09081  carboxyspermidine carboxy-lyase (spermidine-forming)
R09082  carboxynorspermidine carboxy-lyase (norspermidine-forming)
R09255  feruloyl-CoA:agmatine feruloyltransferase
R09256  4-coumaroyl-CoA:putrescine N4-coumaroyltransferase
R09257  feruloyl-CoA:putrescine feruloyltransferase
R09496  D-proline:acceptor oxidoreductase
R10507  L-proline:(acceptor) oxidoreductase
R11604  L-arginine:oxygen oxidoreductase (deaminating)
R11625  cis-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
R11712   
R11713   
R11819  trans-4-hydroxy-L-proline hydro-lyase
R12085  acetyl-CoA:L-glutamate-5-semialdehyde N-acetyltransferase
R12706   
R12707   
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C01877  4-Oxoproline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C04498  p-Coumaroylagmatine
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18325  Feruloylagmatine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
rn00020  Citrate cycle (TCA cycle)
rn00220  Arginine biosynthesis
rn00250  Alanine, aspartate and glutamate metabolism
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00310  Lysine degradation
rn00410  beta-Alanine metabolism
rn00470  D-Amino acid metabolism
rn00480  Glutathione metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00650  Butanoate metabolism
rn00770  Pantothenate and CoA biosynthesis
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
KO pathway
ko00330   
LinkDB

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