| Entry |
|
|---|
| Name |
Sphingolipid metabolism |
|---|
| Class |
Metabolism; Lipid metabolism
|
|---|
| Pathway map |
|
|---|
| Module |
| M00067 | Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:rn00600] |
|
|---|
| Other DBs |
|
|---|
| Reaction |
| R01281 | palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) |
| R01494 | N-acylsphingosine amidohydrolase |
| R01495 | ATP:ceramide 1-phosphotransferase |
| R01496 | acyl-CoA:sphingosine N-acyltransferase |
| R01497 | UDP-glucose:N-acylsphingosine D-glucosyltransferase |
| R01498 | D-glucosyl-N-acylsphingosine glucohydrolase |
| R01500 | UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase |
| R01503 | CDP-ethanolamine:ceramide phosphoethanolaminyltransferase |
| R01891 | CDP-choline:N-acylsphingosine cholinephosphotransferase |
| R01926 | ATP:sphingosine 1-phosphotransferase; sphingosine kinase |
| R01928 | UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase |
| R01929 | CDP-choline:sphingosine cholinephosphotransferase |
| R02464 | sphinganine-1-phosphate pamlmitaldehyde-lyase |
| R02541 | sphingomyelin cholinephosphohydrolase |
| R02542 | sphingomyelin ceramide-phosphohydrolase |
| R02543 | acyl-CoA:sphingosine N-acyltransferase |
| R02976 | ATP:sphinganine 1-phosphotransferase |
| R02978 | sphinganine:NADP+ 3-oxidoreductase |
| R03354 | UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase |
| R03355 | beta-D-galactosyl-1,4-beta-D-glucosylceramide galactohydrolase |
| R03492 | GalNAc-beta1->4Gal-beta1->4Glc-beta1->1'Cer (GA2) N-acetylhexosaminohydrolase |
| R03617 | D-galactosyl-N-acylsphingosine galactohydrolase |
| R03618 | globotriosylceramide galactohydrolase |
| R04017 | 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase |
| R04018 | acylneuraminyl hydrolase |
| R04019 | digalactosylceramide galactohydrolase |
| R04184 | globoside N-acetylhexosaminohydrolase |
| R04586 | N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylhexosaminohydrolase |
| R04633 | D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide galactohydrolase |
| R04856 | sulfatide sulfohydrolase; cerebroside-3-sulfate 3-sulfohydrolase |
| R05105 | 3'-phosphoadenylylsulfate:digalactosylceramide 3'-sulfotransferase |
| R05112 | Gal-beta1->3GalNAc-beta1->4Gal-beta1->4Glc-beta1->1'Cer (GA1) galactohydrolase |
| R06516 | sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) |
| R06517 | acyl-CoA:sphingosine N-acyltransferase |
| R06518 | N-acylsphingosine amidohydrolase |
| R06519 | dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating) |
| R06520 | 3-sn-phosphatidate phosphohydrolase |
| R06521 | 3-sn-phosphatidate phosphohydrolase |
| R06522 | 3-sn-phosphatidate phosphohydrolase |
| R06525 | sphinganine,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating) |
| R06526 | dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating) |
| R06527 | acyl-CoA: phytosphingosine N-acyltransferase |
| R06528 | phytoceramide amidohydrolase |
| R08969 | ceramide:phosphatidylcholine cholinephosphotransferase |
| R12960 | 3'-phosphoadenylyl-sulfate:lactosylceramide 3'-sulfotransferase |
| R12961 | lactosylceramide-sulfate sulfohydrolase |
| R12962 | UDP-N-acetyl-D-galactosamine:lactosylceramide-sulfate N-acetyl-D-galactrosaminyltransferase |
| R12963 | gangliotriaosylceramide-II3-sulfate N-acetylgalactosaminohydrolase |
| R13178 | D-glucosylsphingosine glucohydrolase |
| R13179 | psychosine galactohydrolase |
|
|---|
| Compound |
| C01120 | Sphinganine 1-phosphate |
| C03405 | Lactosylceramide sulfate |
| C03640 | Sphingosyl-phosphocholine |
| C04737 | alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
| C04884 | N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide |
| C04911 | D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide |
| C05681 | Ceramide 2-aminoethylphosphonate |
| C06062 | Ceramide phosphoethanolamine |
| C06124 | Sphingosine 1-phosphate |
| C06127 | Digalactosylceramide sulfate |
| C22467 | Gangliotriaosylceramide-II3 sulfate |
|
|---|
| Reference |
|
|---|
| Authors |
Merrill AH Jr. |
|---|
| Title |
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M. |
|---|
| Title |
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Hannun YA, Luberto C, Argraves KM. |
|---|
| Title |
Enzymes of sphingolipid metabolism: from modular to integrative signaling. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Merrill AH Jr, Wang E. |
|---|
| Title |
Enzymes of ceramide biosynthesis. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Hirschberg K, Rodger J, Futerman AH. |
|---|
| Title |
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Dickson RC, Lester RL. |
|---|
| Title |
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. |
|---|
| Journal |
|
|---|
Related
pathway |
| rn00260 | Glycine, serine and threonine metabolism |
| rn00601 | Glycosphingolipid biosynthesis - lacto and neolacto series |
| rn00603 | Glycosphingolipid biosynthesis - globo and isoglobo series |
| rn00604 | Glycosphingolipid biosynthesis - ganglio series |
|
|---|
| KO pathway |
|
|---|
