KEGG   PATHWAY: rn00600
Entry
rn00600                     Pathway                                
Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
Pathway map
rn00600  Sphingolipid metabolism
rn00600

Module
M00066  Lactosylceramide biosynthesis [PATH:rn00600]
M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:rn00600]
M00094  Ceramide biosynthesis [PATH:rn00600]
M00099  Sphingosine biosynthesis [PATH:rn00600]
M00100  Sphingosine degradation [PATH:rn00600]
Other DBs
GO: 0006665
Reaction
R01281  Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
R01494  N-Acylsphingosine amidohydrolase
R01495  ATP:ceramide 1-phosphotransferase
R01496  acyl-CoA:sphingosine N-acyltransferase
R01497  UDP-glucose:N-acylsphingosine D-glucosyltransferase
R01498  D-glucosyl-N-acylsphingosine glucohydrolase
R01500  UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase
R01503  CDP-ethanolamine:N-acylsphingosine ethanolaminephosphotransferase
R01891  CDP-choline:N-acylsphingosine cholinephosphotransferase
R01926  ATP:sphingosine 1-phosphotransferase
R01928  UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase
R01929  CDP-choline:sphingosine cholinephosphotransferase
R02464  Sphinganine-1-phosphate pamlmitaldehyde-lyase
R02541  Sphingomyelin cholinephosphohydrolase
R02542  Sphingomyelin ceramide-phosphohydrolase
R02543  Acyl-CoA:sphingosine N-acyltransferase
R02976  ATP:sphinganine 1-phosphotransferase
R02978  Sphinganine:NADP+ 3-oxidoreductase
R03354  UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
R03355  beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
R03617  D-galactosyl-N-acylsphingosine galactohydrolase
R04016   
R04017  3'-Phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase
R04018  Acylneuraminyl hydrolase
R04019  Digalactosylceramide galactohydrolase
R04856  Sulfatide sulfohydrolase
R04921   
R05105  3'-Phosphoadenylylsulfate:digalactosylceramide 3'-sulfotransferase
R06516  sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
R06517  acyl-CoA:sphingosine N-acyltransferase
R06518  N-acylsphingosine amidohydrolase
R06519  dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
R06520  3-sn-phosphatidate phosphohydrolase
R06521  3-sn-phosphatidate phosphohydrolase
R06522  3-sn-phosphatidate phosphohydrolase
R06525  sphinganine,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
R06526  dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
R06527  acyl-CoA: phytosphingosine N-acyltransferase
R06528  Phytoceramide amidohydrolase
R08969  ceramide:phosphatidylcholine cholinephosphotransferase
R12960  3'-phosphoadenylyl-sulfate:lactosylceramide 3'-sulfotransferase
R12961  lactosylceramide-sulfate sulfohydrolase
R12962  UDP-N-acetyl-D-galactosamine:lactosylceramide-sulfate N-acetyl-D-galactrosaminyltransferase
R12963  gangliotriaosylceramide-II3-sulfate N-acetylgalactosaminohydrolase
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
rn00260  Glycine, serine and threonine metabolism
rn00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rn00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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