KEGG   PATHWAY: ko00600
Entry
ko00600                     Pathway                                
Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
Pathway map
ko00600  Sphingolipid metabolism
ko00600

Module
M00066  Lactosylceramide biosynthesis [PATH:ko00600]
M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:ko00600]
M00094  Ceramide biosynthesis [PATH:ko00600]
M00099  Sphingosine biosynthesis [PATH:ko00600]
M00100  Sphingosine degradation [PATH:ko00600]
Other DBs
GO: 0006665
Orthology
K00654  SPT; serine palmitoyltransferase [EC:2.3.1.50]
K00720  UGCG; ceramide glucosyltransferase [EC:2.4.1.80]
K00725  B4GALNT1, GALGT; (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase [EC:2.4.1.92]
K01019  GAL3ST1; galactosylceramide sulfotransferase [EC:2.8.2.11]
K01080  PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]
K01117  sph; sphingomyelin phosphodiesterase [EC:3.1.4.12]
K01123  SMaseD; sphingomyelin phosphodiesterase D [EC:3.1.4.41]
K01130  atsA, aslA; arylsulfatase [EC:3.1.6.1]
K01134  ARSA; arylsulfatase A [EC:3.1.6.8]
K01186  NEU1; sialidase-1 [EC:3.2.1.18]
K01189  GLA; alpha-galactosidase [EC:3.2.1.22]
K01190  lacZ; beta-galactosidase [EC:3.2.1.23]
K01201  GBA, srfJ; glucosylceramidase [EC:3.2.1.45]
K01202  GALC; galactosylceramidase [EC:3.2.1.46]
K01441  ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]
K01634  SGPL1, DPL1; sphinganine-1-phosphate aldolase [EC:4.1.2.27]
K04628  CGT, UGT8; ceramide galactosyltransferase [EC:2.4.1.47]
K04708  KDSR; 3-dehydrosphinganine reductase [EC:1.1.1.102]
K04709  LAG1, LAC1; very-long-chain ceramide synthase [EC:2.3.1.297]
K04710  CERS1, LASS1; sphingoid base N-stearoyltransferase [EC:2.3.1.299]
K04711  ACER3, YDC1; dihydroceramidase [EC:3.5.1.-]
K04712  DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
K04713  SUR2; sphinganine C4-monooxygenase [EC:1.14.18.5]
K04714  SGMS; sphingomyelin synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.27 3.1.4.62]
K04715  CERK; ceramide kinase [EC:2.7.1.138]
K04716  SGPP1; sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-]
K04717  SGPP2; sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]
K04718  SPHK; sphingosine kinase [EC:2.7.1.91]
K05848  YPC1; phytoceramidase [EC:3.5.1.-]
K07406  melA; alpha-galactosidase [EC:3.2.1.22]
K07407  E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22]
K07553  B4GALT6; beta-1,4-galactosyltransferase 6 [EC:2.4.1.274]
K09905  B4GALT5; beta-1,4-galactosyltransferase 5 [EC:2.4.1.274 2.4.1.-]
K12309  GLB1, ELNR1; beta-galactosidase [EC:3.2.1.23]
K12348  ASAH1; acid ceramidase [EC:3.5.1.23]
K12349  ASAH2; neutral ceramidase [EC:3.5.1.23]
K12350  SMPD1, ASM; sphingomyelin phosphodiesterase [EC:3.1.4.12]
K12351  SMPD2; sphingomyelin phosphodiesterase 2 [EC:3.1.4.12]
K12352  SMPD3; sphingomyelin phosphodiesterase 3 [EC:3.1.4.12]
K12353  SMPD4; sphingomyelin phosphodiesterase 4 [EC:3.1.4.12]
K12354  ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [EC:3.1.4.12]
K12357  NEU2_3_4; sialidase-2/3/4 [EC:3.2.1.18]
K12373  HEXA_B; hexosaminidase [EC:3.2.1.52]
K12382  PSAP, SGP1; saposin
K12383  GM2A; ganglioside GM2 activator
K17108  GBA2; non-lysosomal glucosylceramidase [EC:3.2.1.45]
K23451  LCB3; dihydrosphingosine 1-phosphate phosphatase
K23550  nanH; sialidase
K23727  CERS5_6, LASS5_6; sphingoid base N-palmitoyltransferase
K24621  CERS2_4, LASS2_4; very-long-chain ceramide synthase
K24622  CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase
K26283  CPES; ceramide phosphoethanolamine synthase
K28194  LOH1_3; very-long-chain ceramide synthase
K28195  LOH2; ceramide synthase
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
ko00260  Glycine, serine and threonine metabolism
ko00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ko00604  Glycosphingolipid biosynthesis - ganglio series

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