Entry |
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Name |
Drug metabolism - other enzymes |
Class |
Metabolism; Xenobiotics biodegradation and metabolism
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Pathway map |
rn00983 | Drug metabolism - other enzymes |

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Reaction |
R08221 | 5'-deoxy-5-fluorocytidine aminohydrolase |
R08222 | 5'-deoxy-5-fluorouridine:phosphate deoxy-alpha-D-ribosyltransferase |
R08226 | 5,6-dihydro-5-fluorouracil:NADP+ 5-oxidoreductase |
R08227 | 5,6-dihydro-5-fluorouracil amidohydrolase |
R08228 | alpha-fluoro-beta-ureidopropionic acid amidohydrolase |
R08229 | 5-fluorouridine:phosphate alpha-D-ribosyltransferase |
R08230 | 5-fluorodeoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase |
R08231 | 5-fluorouridine monophosphate:diphosphate phospho-alpha-D-ribosyl-transferase |
R08232 | ATP:5-fluorouridine 5'-phosphotransferase |
R08233 | ATP:5-fluorodeoxyuridine 5'-phosphotransferase |
R08235 | 6-mercaptopurin:oxygen oxidoreductase |
R08236 | S-adenosyl-L-methionine:6-mercaptopurin S-methyltransferase |
R08237 | 6-thioinosine 5'-monophosphate:diphosphate phospho-D-ribosyltransferase |
R08238 | 6-methylthiopurine 5'-monophosphate ribonucleotide:diphosphate phospho-D-ribosyltransferase |
R08239 | S-adenosyl-L-methionine:6-thioinosine 5'-monophosphate S-methyltransferase |
R08240 | 6-thioinosine 5'-monophosphate:NAD+ oxidoreductase |
R08243 | inosine triphosphate pyrophosphatase |
R08244 | 6-thioxanthine 5'-monophosphate:L-glutamine amido-ligase (AMP-forming) |
R08245 | 6-thioguanosine monophosphate:diphosphate phospho-D-ribosyltransferase |
R08246 | S-adenosyl-L-methionine:6-thioguanosine monophosphate S-methyltransferase |
R08248 | acetyl-CoA: isoniazid N-acetyltransferase |
R08249 | N-acetylisoniazid amidohydrolase |
R08250 | acetyl-CoA:acetylhydrazine N-acetyltransferase |
R08251 | isoniazid amidohydrolase |
R08260 | SN38 glucuronide glucuronosohydrolase |
R11891 | ATP:5-fluorouridine-monophosphate phosphotransferase |
R11892 | ATP:5-fluorodeoxyuridine-monophosphate phosphotransferase |
R11893 | 5-fluorodeoxyuridine-diphosphate:thioredoxin-disulfide 2'-oxidoreductase |
R11894 | ATP:5-fluorouridine-diphosphate phosphotransferase |
R11895 | ATP:5-fluorodeoxyuridine-diphosphate phosphotransferase |
R11896 | 5-fluorodeoxyuridine-triphosphate diphosphohydrolase |
R11902 | acetyl-CoA:hydrazine N-acetyltransferase |
R11903 | acetylhydrazine amidohydrolase |
R11904 | acetylhydrazine,NADPH:oxygen oxidoreductase |
R11906 | isoniazid:hydrogen-peroxide oxidoreductase |
|
Compound |
C04242 | 5-Fluorodeoxyuridine monophosphate |
C04646 | 6-Thioinosine-5'-monophosphate |
C12739 | 5'-Deoxy-5-fluorouridine |
C16615 | 6-Methylthiopurine 5'-monophosphate ribonucleotide |
C16616 | 6-Mercaptopurine ribonucleoside 5'-diphosphate |
C16617 | 6-Mercaptopurine ribonucleoside triphosphate |
C16618 | 6-Thioxanthine 5'-monophosphate |
C16619 | 6-Thioguanosine monophosphate |
C16620 | 6-Methylthioguanosine monophosphate |
C16621 | 1-Methyl-4-nitroimidazole |
C16625 | Isoniazid alpha-ketoglutaric acid |
C16630 | 5,6-Dihydro-5-fluorouracil |
C16631 | alpha-Fluoro-beta-ureidopropionic acid |
C16632 | alpha-Fluoro-beta-alanine |
C16634 | 5-Fluorouridine monophosphate |
C16635 | 5'-Deoxy-5-fluorocytidine |
C21748 | 5-Fluorouridine diphosphate |
C21749 | 5-Fluorouridine triphosphate |
C21750 | 5-Fluorodeoxyuridine diphosphate |
C21751 | 5-Fluorodeoxyuridine triphosphate |
C21759 | Isonicotinoyl-NAD adduct |
C21760 | Isonicotinoyl-NADP adduct |
D00238 | Azathioprine (JP18/USP/INN) |
D00346 | Isoniazid (JP18/USP/INN) |
D00584 | Fluorouracil (JP18/USP/INN) |
D01223 | Capecitabine (JAN/USP/INN) |
D01244 | Tegafur (JP18/USAN/INN) |
D01309 | Doxifluridine (JP18/INN) |
|
Reference |
|
Authors |
Kato R, Kamatari T (eds). |
Title |
[Drug Metabolism] (In Japanese) |
Journal |
Tokyo Kagaku Dojin (2000) |
Reference |
|
Authors |
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR. |
Title |
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. |
Journal |
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Reference |
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Authors |
Gearry RB, Barclay ML. |
Title |
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. |
Journal |
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Reference |
|
Authors |
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG. |
Title |
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. |
Journal |
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Reference |
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Authors |
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G. |
Title |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes. |
Journal |
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Reference |
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Authors |
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H. |
Title |
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. |
Journal |
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Reference |
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Authors |
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR |
Title |
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy. |
Journal |
|
Reference |
|
Authors |
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A |
Title |
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). |
Journal |
Clin Cancer Res 7:2182-94 (2001) |
Reference |
|
Authors |
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K. |
Title |
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients. |
Journal |
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Reference |
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Authors |
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I |
Title |
5-fu metabolism in cancer and orally-administrable 5-fu drugs. |
Journal |
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Reference |
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Authors |
Wang P, Pradhan K, Zhong XB, Ma X |
Title |
Isoniazid metabolism and hepatotoxicity. |
Journal |
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Reference |
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Authors |
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE |
Title |
PharmGKB summary: isoniazid pathway, pharmacokinetics. |
Journal |
|
Reference |
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Authors |
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A |
Title |
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity. |
Journal |
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Reference |
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Authors |
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C |
Title |
Mechanisms of catalase activity of heme peroxidases. |
Journal |
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Reference |
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Authors |
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG |
Title |
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites. |
Journal |
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Reference |
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Authors |
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ |
Title |
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation. |
Journal |
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Reference |
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Authors |
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B |
Title |
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis. |
Journal |
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Reference |
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Authors |
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC |
Title |
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis. |
Journal |
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Reference |
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Authors |
Argyrou A, Vetting MW, Blanchard JS |
Title |
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP. |
Journal |
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KO pathway |
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