KEGG PATHWAY: roa00760

KEGG

PATHWAY: roa00760

Entry

roa00760                    Pathway

Name

Nicotinate and nicotinamide metabolism - Rhodococcus opacus PD630

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

Nicotinate and nicotinamide metabolism

Module

NAD biosynthesis, aspartate => quinolinate => NAD [PATH:roa00760]

Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde [PATH:roa00760]

Other DBs

UMBBD:

GO:	0046497 0006769

Organism

Rhodococcus opacus PD630 [GN:roa]

Gene

L-aspartate oxidase [KO:K00278] [EC:1.4.3.16]

Quinolinate synthase A [KO:K03517] [EC:2.5.1.72]

Nicotinate-nucleotide pyrophosphorylase [carboxylating] [KO:K00767] [EC:2.4.2.19]

Nicotinate phosphoribosyltransferase pncB1 [KO:K00763] [EC:6.3.4.21]

Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]

Endonuclease YhcR [KO:K01081] [EC:3.1.3.5]

Protein nagD [KO:K02566] [EC:3.1.3.5]

putative nicotinate-nucleotide adenylyltransferase [KO:K00969] [EC:2.7.7.18]

Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]

NADH pyrophosphatase [KO:K03426] [EC:3.6.1.22]

NH(3)-dependent NAD(+) synthetase [KO:K01916] [EC:6.3.1.5]

Putative competence-damage inducible protein [KO:K03743] [EC:3.5.1.42]

CinA-like protein [KO:K03743] [EC:3.5.1.42]

Pyrazinamidase/nicotinamidase [KO:K08281] [EC:3.5.1.19 3.5.1.-]

putative inorganic polyphosphate/ATP-NAD kinase [KO:K00858] [EC:2.7.1.23]

NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:7.1.1.1]

NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:7.1.1.1]

hypothetical protein [KO:K18028] [EC:1.13.11.9]

Tropinesterase [KO:K15357] [EC:3.5.1.106]

N-carbamoylsarcosine amidase [KO:K13995] [EC:3.5.1.107]

Arylmalonate decarboxylase [KO:K01799] [EC:5.2.1.1]

hypothetical protein [KO:K01799] [EC:5.2.1.1]

hypothetical protein [KO:K01799] [EC:5.2.1.1]

Carbon monoxide dehydrogenase medium chain [KO:K19818] [EC:1.5.99.4]

Carbon monoxide dehydrogenase small chain [KO:K19819] [EC:1.5.99.4]

Carbon monoxide dehydrogenase large chain [KO:K19820] [EC:1.5.99.4]

Amine oxidase [flavin-containing] A [KO:K19826] [EC:1.5.3.5]

putative succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Putative succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

betaine aldehyde dehydrogenase [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Putative succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [NADP+] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Succinate-semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]

Carbon monoxide dehydrogenase medium chain [KO:K19185] [EC:1.5.99.14]

Carbon monoxide dehydrogenase small chain [KO:K19186] [EC:1.5.99.14]

Carbon monoxide dehydrogenase large chain [KO:K19187] [EC:1.5.99.14]

2,6-dihydropseudooxynicotine hydrolase [KO:K19188] [EC:3.7.1.19]

6-hydroxynicotinate 3-monooxygenase [KO:K19189] [EC:1.14.13.10]

Compound

NAD+

NADP+

Pyruvate

Succinate

L-Aspartate

Glycerone phosphate

Fumarate

Nicotinamide

Propanoate

Succinate semialdehyde

Nicotinate

4-Aminobutanoate

Nicotinamide D-ribonucleotide

Nicotine

Deamino-NAD+

2,3-Dimethylmaleate

6-Hydroxynicotinate

(S)-6-Hydroxynicotine

2,5-Dihydroxypyridine

Nicotinate D-ribonucleotide

6-Hydroxypseudooxynicotine

Maleic acid

Maleamate

Methylitaconate

1-Methylnicotinamide

2-Methyleneglutarate

(R)-6-Hydroxynicotine

2,6-Dihydroxypyridine

Nicotinamide-beta-riboside

2,3,6-Trihydroxypyridine

(2R,3S)-2,3-Dimethylmalate

Quinolinate

6-Oxo-1,4,5,6-tetrahydronicotinate

Nicotinurate

Iminoaspartate

Nicotinate D-ribonucleoside

N1-Methyl-2-pyridone-5-carboxamide

N1-Methyl-4-pyridone-5-carboxamide

1-Methylpyrrolinium

2,6-Dihydroxynicotinate

2,6-Dihydroxypseudooxynicotine

4-Methylaminobutyrate

2,6-Dihydroxy-N-methylmyosmine

Blue pigment

2-Formylglutarate

(R)-Nicotine

(S)-2-(Hydroxymethyl)glutarate

N-Formylmaleamic acid

4-Oxo-1-(3-pyridyl)-1-butanone

3-Succinoylpyridine

6-Hydroxy-3-succinoylpyridine

Pseudooxynicotine

3,3'-Bipyridine-2,2',5,5',6,6'-hexol

5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol

N-Methylmyosmine

Reference

Authors

BEHRMAN EJ, STANIER RY.

Title

The bacterial oxidation of nicotinic acid.

Journal

J Biol Chem 228:923-45 (1957)

Reference

Authors

Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.

Title

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.

Journal

Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103

Reference

Authors

Baitsch D, Sandu C, Brandsch R, Igloi GL.

Title

Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.

Journal

J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001

Reference

Authors

Sachelaru P, Schiltz E, Igloi GL, Brandsch R.

Title

An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.

Journal

J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005

Reference

Authors

Gherna RL, Richardson SH, Rittenberg SC

Title

The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.

Journal

J Biol Chem 240:3669-74 (1965)

Reference

Authors

Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N

Title

Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.

Journal

J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818

Related
pathway

Citrate cycle (TCA cycle)

Alanine, aspartate and glutamate metabolism

Tryptophan metabolism

Pyruvate metabolism

C5-Branched dibasic acid metabolism

KO pathway

LinkDB

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