KEGG   PATHWAY: ko00760
Entry
ko00760                     Pathway                                
Name
Nicotinate and nicotinamide metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00760  Nicotinate and nicotinamide metabolism
ko00760

Module
M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:ko00760]
M00622  Nicotinate degradation, nicotinate => fumarate [PATH:ko00760]
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde [PATH:ko00760]
M00811  Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde [PATH:ko00760]
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:ko00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Orthology
K00135  gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
K00157  AOX; aldehyde oxidase [EC:1.2.3.1]
K00278  nadB; L-aspartate oxidase [EC:1.4.3.16]
K00322  sthA, udhA; NAD(P) transhydrogenase [EC:1.6.1.1]
K00323  NNT; proton-translocating NAD(P)+ transhydrogenase [EC:7.1.1.1]
K00324  pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]
K00325  pntB; proton-translocating NAD(P)+ transhydrogenase subunit beta [EC:7.1.1.1]
K00541  NNMT; nicotinamide N-methyltransferase [EC:2.1.1.1]
K00763  pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]
K00767  nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]
K00858  ppnK, NADK; NAD+ kinase [EC:2.7.1.23]
K00952  nadM; nicotinamide-nucleotide adenylyltransferase [EC:2.7.7.1]
K00969  nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]
K01081  E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01240  URH1; uridine nucleosidase [EC:3.2.2.3]
K01242  CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]
K01440  PNC1; nicotinamidase [EC:3.5.1.19]
K01513  ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
K01799  nicE, maiA; maleate isomerase [EC:5.2.1.1]
K01916  nadE; NAD+ synthase [EC:6.3.1.5]
K01950  E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]
K02566  nagD; 5'-nucleotidase [EC:3.1.3.5]
K03426  NUDT12_13, nudC; NAD+ diphosphatase [EC:3.6.1.22]
K03462  NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
K03517  nadA; quinolinate synthase [EC:2.5.1.72]
K03742  pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]
K03743  pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]
K03783  punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1]
K03784  deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]
K03787  surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6]
K04765  mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]
K06210  NMNAT; nicotinamide mononucleotide adenylyltransferase [EC:2.7.7.1 2.7.7.18]
K06211  nadR; HTH-type transcriptional regulator, transcriptional repressor of NAD biosynthesis genes [EC:2.7.7.1 2.7.1.22]
K06989  nadX, ASPDH; aspartate dehydrogenase [EC:1.4.1.21]
K08281  pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-]
K08324  sad; succinate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.24]
K08693  yfkN; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase / 5'-nucleotidase [EC:3.1.4.16 3.1.3.6 3.1.3.5]
K10524  NRK1_2; nicotinamide/nicotinate riboside kinase [EC:2.7.1.22 2.7.1.173]
K11121  SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  SIRT2, SIR2L2; NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  SIRT4, SIR2L4; NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  SIRT5, SIR2L5; NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  SIRT6, SIR2L6; NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  SIRT7, SIR2L7; NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K11751  ushA; 5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45]
K12410  cobB, srtN, npdA; NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
K13522  K13522, nadM; bifunctional NMN adenylyltransferase/nudix hydrolase [EC:2.7.7.1 3.6.1.-]
K13995  nicF; maleamate amidohydrolase [EC:3.5.1.107]
K14974  nicC; 6-hydroxynicotinate 3-monooxygenase [EC:1.14.13.114]
K15357  nicD; N-formylmaleamate deformylase [EC:3.5.1.106]
K15358  ena; enamidase [EC:3.5.2.18]
K15359  hspA; 6-hydroxy-3-succinoylpyridine 3-monooxygenase [EC:1.14.13.163]
K18028  nicX; 2,5-dihydroxypyridine 5,6-dioxygenase [EC:1.13.11.9]
K18029  nicA; nicotinate dehydrogenase subunit A [EC:1.17.2.1]
K18030  nicB; nicotinate dehydrogenase subunit B [EC:1.17.2.1]
K18152  BST1, CD157; ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]
K18153  nga; NAD+ glycohydrolase [EC:3.2.2.5]
K18276  hspB; 6-hydroxy-3-succinoylpyridine 3-monooxygenase [EC:1.14.13.163]
K18550  ISN1; IMP and pyridine-specific 5'-nucleotidase [EC:3.1.3.99 3.1.3.-]
K18551  SDT1; pyrimidine and pyridine-specific 5'-nucleotidase [EC:3.1.3.-]
K19185  kdhA; 6-hydroxypseudooxynicotine dehydrogenase subunit alpha [EC:1.5.99.14]
K19186  kdhB; 6-hydroxypseudooxynicotine dehydrogenase subunit beta [EC:1.5.99.14]
K19187  kdhL; 6-hydroxypseudooxynicotine dehydrogenase subunit gamma [EC:1.5.99.14]
K19188  dhponh; 2,6-dihydroxypseudooxynicotine hydrolase [EC:3.7.1.19]
K19189  dhpH; 2,6-dihydroxypyridine 3-monooxygenase [EC:1.14.13.10]
K19190  nboR; nicotine blue oxidoreductase [EC:1.1.1.328]
K19191  mabO; 4-methylaminobutanoate oxidase (formaldehyde-forming) [EC:1.5.3.19]
K19647  hgd; 2-hydroxymethylglutarate dehydrogenase [EC:1.1.1.291]
K19700  sap; 3-succinoylsemialdehyde-pyridine dehydrogenase [EC:1.2.1.83]
K19785  POF1; nicotinamide-nucleotide adenylyltransferase [EC:2.7.7.1]
K19818  ndhA; nicotine dehydrogenase subunit A [EC:1.5.99.4]
K19819  ndhB; nicotine dehydrogenase subunit B [EC:1.5.99.4]
K19820  ndhC; nicotine dehydrogenase subunit C [EC:1.5.99.4]
K19826  nctB, 6-hlno; (S)-6-hydroxynicotine oxidase [EC:1.5.3.5]
K19890  6-hdno; (R)-6-hydroxynicotine oxidase [EC:1.5.3.6]
K19970  NT5E, CD73; 5'-nucleotidase [EC:3.1.3.5]
K19980  ART2, RT6; ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:2.4.2.31 3.2.2.5]
K20155  mao; 4-methylaminobutanoate oxidase (methylamine-forming) [EC:1.5.3.21]
K20158  pao; pseudooxynicotine dehydrogenase [EC:1.4.2.3]
K20169  nox, nicA2; nicotine dehydrogenase [EC:1.4.2.2]
K20170  nicA1; nicotine oxidoreductase
K20171  spmA; 3-succinoylpyridine monooxygenase subunit A
K20172  spmC; 3-succinoylpyridine monooxygenase subunit C
K20445  ndhF; nicotinate dehydrogenase FAD-subunit [EC:1.17.1.5]
K20446  ndhS; nicotinate dehydrogenase small FeS subunit [EC:1.17.1.5]
K20447  ndhL; nicotinate dehydrogenase large molybdopterin subunit [EC:1.17.1.5]
K20448  ndhM; nicotinate dehydrogenase medium molybdopterin subunit [EC:1.17.1.5]
K20449  hnr; 6-hydroxynicotinate reductase [EC:1.3.7.1]
K20450  mgm; 2-methyleneglutarate mutase [EC:5.4.99.4]
K20451  mii; methylitaconate Delta-isomerase [EC:5.3.3.6]
K20452  dmdA; dimethylmaleate hydratase large subunit [EC:4.2.1.85]
K20453  dmdB; dimethylmaleate hydratase small subunit [EC:4.2.1.85]
K20454  dml; 2,3-dimethylmalate lyase [EC:4.1.3.32]
K26956  NUDT2_6_7_10; ADP-ribose/NAD+ diphosphatase
K27536  SARM1, SAMD2; NAD(+) hydrolase SARM1
K28299  tse6; NAD(P)(+) glycohydrolase toxin Tse6
K28925  NIC1; nicotinamidase
K28926  NIC2_3; nicotinamidase
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21154  N-Methylmyosmine
C23137  5-(6-Hydroxypyridin-3-yl)-1-methyl-3,4-dihydro-2H-pyrrol-1-ium
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00250  Alanine, aspartate and glutamate metabolism
ko00380  Tryptophan metabolism
ko00620  Pyruvate metabolism
ko00660  C5-Branched dibasic acid metabolism
ko00960  Tropane, piperidine and pyridine alkaloid biosynthesis

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