KEGG   PATHWAY: rro04740
Entry
rro04740                    Pathway                                
Name
Olfactory transduction - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.
Class
Organismal Systems; Sensory system
Pathway map
rro04740  Olfactory transduction
rro04740

Other DBs
GO: 0007608
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653553  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104653554  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
104653686  [KO:K04257]
104653688  [KO:K04257]
104653689  [KO:K04257]
104653690  [KO:K04257]
104653692  [KO:K04257]
104653693  [KO:K04257]
104653694  [KO:K04257]
104653695  [KO:K04257]
104653696  [KO:K04257]
104653697  [KO:K04257]
104654225  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
104654297  [KO:K04257]
104654301  [KO:K04257]
104654533  [KO:K04257]
104654534  [KO:K04257]
104654535  [KO:K04257]
104654536  [KO:K04257]
104654537  [KO:K04257]
104654538  [KO:K04257]
104654539  [KO:K04257]
104654540  [KO:K04257]
104654544  [KO:K04257]
104654813  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
104654849  [KO:K04257]
104654854  [KO:K04257]
104654855  [KO:K04257]
104654869  [KO:K04257]
104656249  [KO:K04257]
104656250  [KO:K04257]
104656298  [KO:K04257]
104656300  [KO:K04257]
104656372  [KO:K04257]
104656374  [KO:K04257]
104656375  [KO:K04257]
104656376  [KO:K04257]
104656377  [KO:K04257]
104656378  [KO:K04257]
104656380  [KO:K04257]
104656381  [KO:K04257]
104656382  [KO:K04257]
104656387  [KO:K04257]
104656388  [KO:K04257]
104656391  [KO:K04257]
104656395  [KO:K04257]
104656749  [KO:K04257]
104656752  [KO:K04257]
104656754  [KO:K04257]
104656772  [KO:K04257]
104656871  [KO:K02183]
104657024  [KO:K04257]
104657026  [KO:K04257]
104657027  [KO:K04257]
104657029  [KO:K04257]
104657037  [KO:K04257]
104657038  [KO:K04257]
104657041  [KO:K04257]
104657383  [KO:K04257]
104657384  [KO:K04257]
104657386  [KO:K04257]
104657387  [KO:K04257]
104657388  [KO:K04257]
104657697  [KO:K04257]
104657698  [KO:K04257]
104657699  [KO:K04257]
104657701  [KO:K04257]
104657702  [KO:K04257]
104657877  [KO:K04257]
104657878  [KO:K04257]
104657886  [KO:K04257]
104658457  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
104658538  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
104658784  [KO:K04257]
104658785  [KO:K04257]
104659291  [KO:K04257]
104659402  [KO:K04257]
104659421  [KO:K04257]
104659508  [KO:K04257]
104659649  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
104659714  [KO:K04257]
104659715  [KO:K04257]
104660224  [KO:K04257]
104660374  [KO:K04257]
104660375  [KO:K04257]
104660377  [KO:K04257]
104660378  [KO:K04257]
104660380  [KO:K04257]
104660383  [KO:K04257]
104660384  [KO:K04257]
104660423  [KO:K04257]
104660452  [KO:K04257]
104660454  [KO:K04257]
104660938  [KO:K04257]
104661010  [KO:K04257]
104661028  [KO:K04257]
104661033  [KO:K04257]
104661051  [KO:K04345] [EC:2.7.11.11]
104661136  [KO:K04257]
104661476  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
104661674  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
104661904  [KO:K04257]
104662055  [KO:K02183]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104662332  [KO:K04257]
104662334  [KO:K04257]
104662335  [KO:K04257]
104662336  [KO:K04257]
104662337  [KO:K04257]
104662338  [KO:K04257]
104662342  [KO:K04257]
104662344  [KO:K04257]
104662346  [KO:K04257]
104662590  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
104663009  [KO:K04257]
104663033  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
104663095  ARRB2; beta-arrestin-2 isoform X4 [KO:K04439]
104663170  CALM2; calmodulin-2 [KO:K02183]
104663383  [KO:K04257]
104663395  [KO:K04257]
104663396  [KO:K04257]
104663397  [KO:K04257]
104663398  [KO:K04257]
104663402  [KO:K04257]
104663404  [KO:K04257]
104663445  [KO:K04257]
104664064  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
104664749  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
104664834  CALML5; calmodulin-like protein 5 [KO:K02183]
104664835  CALML3; calmodulin-like protein 3 [KO:K02183]
104665104  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
104665149  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
104665177  [KO:K04257]
104665180  [KO:K04257]
104665181  [KO:K04257]
104665183  [KO:K04257]
104665185  [KO:K04257]
104665186  [KO:K04257]
104665190  [KO:K04257]
104665202  [KO:K04257]
104665213  [KO:K04257]
104665214  [KO:K04257]
104665216  [KO:K04257]
104665217  [KO:K04257]
104665805  [KO:K04257]
104666593  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
104667054  [KO:K04257]
104667500  [KO:K04257]
104667533  [KO:K04257]
104667622  [KO:K04257]
104667682  [KO:K04257]
104668189  [KO:K04257]
104668191  [KO:K04257]
104669017  [KO:K04257]
104669063  [KO:K04257]
104669064  [KO:K04257]
104669207  [KO:K04257]
104669820  [KO:K04257]
104669821  [KO:K04257]
104669984  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104670012  [KO:K04257]
104670016  [KO:K04257]
104670245  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
104670410  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104670544  CALM1; calmodulin-1 [KO:K02183]
104670555  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
104670779  [KO:K04257]
104670780  [KO:K04257]
104670781  [KO:K04257]
104670782  [KO:K04257]
104670783  [KO:K04257]
104670784  [KO:K04257]
104670785  [KO:K04257]
104670833  NCALD; neurocalcin-delta [KO:K19695]
104670835  [KO:K04257]
104670844  [KO:K04257]
104671146  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
104671203  [KO:K04257]
104671381  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
104671505  [KO:K04257]
104671506  [KO:K04257]
104671522  [KO:K04257]
104671897  RGS2; regulator of G-protein signaling 2 [KO:K18154]
104671949  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
104672307  [KO:K04257]
104672326  [KO:K04257]
104672344  [KO:K04257]
104672608  [KO:K04257]
104672634  [KO:K04257]
104672787  [KO:K04257]
104672883  [KO:K04257]
104672884  [KO:K04257]
104672886  [KO:K04257]
104672887  [KO:K04257]
104672889  [KO:K04257]
104672890  [KO:K04257]
104672891  [KO:K04257]
104673103  [KO:K04257]
104673104  [KO:K04257]
104673105  [KO:K04257]
104673106  [KO:K04257]
104673107  [KO:K04257]
104673108  [KO:K04257]
104673109  [KO:K04257]
104673110  [KO:K04257]
104673111  [KO:K04257]
104673112  [KO:K04257]
104673113  [KO:K04257]
104673130  [KO:K04257]
104673133  [KO:K04257]
104673135  [KO:K04257]
104673136  [KO:K04257]
104673139  [KO:K04257]
104673142  [KO:K04257]
104673143  [KO:K04257]
104673144  [KO:K04257]
104673145  [KO:K04257]
104673146  [KO:K04257]
104673384  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
104673406  CALM3; calmodulin-3 [KO:K02183]
104673576  [KO:K04257]
104673639  [KO:K04257]
104673718  [KO:K04257]
104673721  [KO:K04257]
104673722  [KO:K04257]
104674012  [KO:K04257]
104674030  [KO:K04257]
104674031  [KO:K04257]
104674128  [KO:K04257]
104674164  [KO:K04257]
104674211  [KO:K02183]
104674913  [KO:K04257]
104674927  [KO:K04257]
104674932  [KO:K04257]
104674933  [KO:K04257]
104674934  [KO:K04257]
104674935  [KO:K04257]
104674936  [KO:K04257]
104674937  [KO:K04257]
104674938  [KO:K04257]
104674941  [KO:K04257]
104674942  [KO:K04257]
104674946  [KO:K04257]
104674953  [KO:K04257]
104674954  [KO:K04257]
104674956  [KO:K04257]
104674993  [KO:K04257]
104674994  [KO:K04257]
104675855  [KO:K04257]
104676623  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
104676729  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
104676761  [KO:K04257]
104676762  [KO:K04257]
104676763  [KO:K04257]
104676767  [KO:K04257]
104676853  [KO:K04257]
104676929  [KO:K04257]
104676930  [KO:K04257]
104676932  [KO:K04257]
104677200  [KO:K04257]
104677201  [KO:K04257]
104677205  [KO:K04257]
104677206  [KO:K04257]
104677241  [KO:K04257]
104677242  [KO:K04257]
104677243  [KO:K04257]
104677244  [KO:K04257]
104677245  [KO:K04257]
104677246  [KO:K04257]
104677247  [KO:K04257]
104677254  [KO:K04257]
104677255  [KO:K04257]
104677268  [KO:K04257]
104677269  [KO:K04257]
104677288  [KO:K04257]
104677448  [KO:K04257]
104677449  [KO:K04257]
104677451  [KO:K04257]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104677518  [KO:K04257]
104677671  [KO:K04257]
104677673  [KO:K04257]
104677674  [KO:K04257]
104677675  [KO:K04257]
104677676  [KO:K04257]
104677677  [KO:K04257]
104677678  [KO:K04257]
104677691  [KO:K04257]
104677693  [KO:K04257]
104678124  [KO:K04257]
104678132  [KO:K04257]
104678140  [KO:K04257]
104678148  [KO:K04257]
104678157  [KO:K04257]
104678161  [KO:K04257]
104678170  [KO:K04257]
104678186  [KO:K04257]
104678187  [KO:K04257]
104678189  [KO:K04257]
104678192  [KO:K04257]
104678194  [KO:K04257]
104678195  [KO:K04257]
104678198  [KO:K04257]
104678204  [KO:K04257]
104678214  [KO:K04257]
104678223  [KO:K04257]
104678233  [KO:K04257]
104678242  [KO:K04257]
104678265  [KO:K04257]
104678283  [KO:K04257]
104678284  [KO:K04257]
104678288  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
104678308  [KO:K04257]
104678310  [KO:K04257]
104678311  [KO:K04257]
104679042  SLC24A4; sodium/potassium/calcium exchanger 4 [KO:K13752]
104679148  [KO:K04257]
104679159  [KO:K04257]
104679161  [KO:K04257]
104679435  [KO:K04257]
104679436  [KO:K04257]
104679438  [KO:K04257]
104679439  [KO:K04257]
104679440  [KO:K04257]
104679441  [KO:K04257]
104679442  [KO:K04257]
104679456  [KO:K04257]
104680136  ANO2; anoctamin-2 [KO:K19497]
104680413  [KO:K04257]
104680414  [KO:K04257]
104680741  [KO:K02183]
104681130  [KO:K04257]
104681131  [KO:K04257]
104681134  [KO:K04257]
104681135  [KO:K04257]
104681136  [KO:K04257]
104681137  [KO:K04257]
104681138  [KO:K04257]
104681140  [KO:K04257]
104681141  [KO:K04257]
104681143  [KO:K04257]
104681144  [KO:K04257]
104681145  [KO:K04257]
104681146  [KO:K04257]
104681147  [KO:K04257]
104681148  [KO:K04257]
104681155  [KO:K04257]
104681156  [KO:K04257]
104681158  [KO:K04257]
104681159  [KO:K04257]
104681460  [KO:K04257]
104681934  [KO:K04257]
104681968  [KO:K04257]
104681969  [KO:K04257]
104681970  [KO:K04257]
104682280  [KO:K04257]
104682284  [KO:K04257]
104682285  [KO:K04257]
104682286  [KO:K04257]
104682292  [KO:K04257]
104682295  [KO:K04257]
104682641  [KO:K04257]
104682642  [KO:K04257]
104682644  [KO:K04257]
104682647  [KO:K04257]
104682648  [KO:K04257]
104682650  [KO:K04257]
104682652  [KO:K04257]
115892031  [KO:K04257]
115893452  [KO:K04257]
115893488  [KO:K04257]
115893625  [KO:K04257]
115893627  [KO:K04257]
115893631  [KO:K04257]
115893654  [KO:K04257]
115895307  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
115897424  [KO:K04257]
115897462  [KO:K04257]
115898359  [KO:K04257]
115898381  [KO:K04257]
115898993  [KO:K04257]
115899004  [KO:K04257]
115899139  [KO:K04257]
Compound
C00020  AMP
C00076  Calcium cation
C00144  GMP
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
Reference
PMID:20145624
  Authors
Kaupp UB
  Title
Olfactory signalling in vertebrates and insects: differences and commonalities.
  Journal
Nat Rev Neurosci 11:188-200 (2010)
DOI:10.1038/nrn2789
Reference
PMID:24733839
  Authors
Peterlin Z, Firestein S, Rogers ME
  Title
The state of the art of odorant receptor deorphanization: a report from the orphanage.
  Journal
J Gen Physiol 143:527-42 (2014)
DOI:10.1085/jgp.201311151
Reference
PMID:19652915
  Authors
Kato A, Touhara K
  Title
Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization.
  Journal
Cell Mol Life Sci 66:3743-53 (2009)
DOI:10.1007/s00018-009-0111-6
Reference
PMID:11557990
  Authors
Firestein S.
  Title
How the olfactory system makes sense of scents.
  Journal
Nature 413:211-8 (2001)
DOI:10.1038/35093026
Reference
PMID:16269360
  Authors
Ache BW, Young JM.
  Title
Olfaction: diverse species, conserved principles.
  Journal
Neuron 48:417-30 (2005)
DOI:10.1016/j.neuron.2005.10.022
Reference
PMID:10944513
  Authors
Zufall F, Leinders-Zufall T.
  Title
The cellular and molecular basis of odor adaptation.
  Journal
Chem Senses 25:473-81 (2000)
DOI:10.1093/chemse/25.4.473
Reference
PMID:22875451
  Authors
Lodovichi C, Belluscio L
  Title
Odorant receptors in the formation of the olfactory bulb circuitry.
  Journal
Physiology (Bethesda) 27:200-12 (2012)
DOI:10.1152/physiol.00015.2012
Reference
PMID:12488531
  Authors
Kohout TA, Lefkowitz RJ.
  Title
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
  Journal
Mol Pharmacol 63:9-18 (2003)
DOI:10.1124/mol.63.1.9
Reference
PMID:22735517
  Authors
De Palo G, Boccaccio A, Miri A, Menini A, Altafini C
  Title
A dynamical feedback model for adaptation in the olfactory transduction pathway.
  Journal
Biophys J 102:2677-86 (2012)
DOI:10.1016/j.bpj.2012.04.040
Reference
PMID:19941039
  Authors
Zufall F, Munger SD
  Title
Receptor guanylyl cyclases in mammalian olfactory function.
  Journal
Mol Cell Biochem 334:191-7 (2010)
DOI:10.1007/s11010-009-0325-9
Reference
PMID:19306880
  Authors
Duda T, Sharma RK
  Title
Ca2+-modulated ONE-GC odorant signal transduction.
  Journal
FEBS Lett 583:1327-30 (2009)
DOI:10.1016/j.febslet.2009.03.036
Related
pathway
rro00230  Purine metabolism
rro04024  cAMP signaling pathway
KO pathway
ko04740   

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