KEGG   PATHWAY: rro00230
Entry
rro00230                    Pathway                                
Name
Purine metabolism - Rhinopithecus roxellana (golden snub-nosed monkey)
Class
Metabolism; Nucleotide metabolism
Pathway map
rro00230  Purine metabolism
rro00230

Module
rro_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:rro00230]
rro_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:rro00230]
rro_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:rro00230]
rro_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:rro00230]
rro_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:rro00230]
rro_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:rro00230]
rro_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:rro00230]
Other DBs
GO: 0006163 0042278
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104654191  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
104654204  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
104654225  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
104654477  AK7; adenylate kinase 7 isoform X2 [KO:K00939] [EC:2.7.4.3]
104654871  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
104654875  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
104654949  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
104655013  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
104655148  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
104655176  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
104655715  PAICS; multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
104655716  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
104655958  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
104655979  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
104656009  AMPD2; AMP deaminase 2 isoform X3 [KO:K01490] [EC:3.5.4.6]
104656534  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
104656952  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2 [KO:K18437] [EC:3.1.4.53]
104657284  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
104657322  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
104657740  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104657741  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104658021  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
104658028  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
104658100  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
104658102  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
104658457  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
104658629  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
104658753  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104658893  HDDC2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
104659869  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X2 [KO:K01510] [EC:3.6.1.5]
104659929  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
104660006  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
104660696  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
104660878  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
104661029  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
104661674  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
104661688  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
104661692  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
104662192  [KO:K00088] [EC:1.1.1.205]
104662269  [KO:K00088] [EC:1.1.1.205]
104662674  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104662685  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
104662724  [KO:K12319] [EC:4.6.1.2]
104663412  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
104663522  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
104663590  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
104664350  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
104664407  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
104664442  [KO:K22600] [EC:4.6.1.2]
104664517  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
104664681  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
104664884  NUDT5; ADP-sugar pyrophosphatase isoform X2 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
104665149  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
104665174  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
104665472  [KO:K00939] [EC:2.7.4.3]
104665872  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
104666071  LACC1; laccase domain-containing protein 1 isoform X2 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
104666392  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
104666399  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
104666414  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
104666593  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
104666769  ADA2; LOW QUALITY PROTEIN: adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
104667448  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
104667568  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
104668067  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
104668077  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
104668142  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104668292  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
104668790  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
104668871  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
104668974  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
104669079  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
104669241  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
104669616  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
104669638  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X2 [KO:K01509] [EC:3.6.1.-]
104669744  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
104669985  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
104669989  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
104670049  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104670476  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X4 [KO:K13293] [EC:3.1.4.53]
104670555  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
104671165  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
104671297  NME6; nucleoside diphosphate kinase 6 isoform X2 [KO:K00940] [EC:2.7.4.6]
104671715  PDE6B; LOW QUALITY PROTEIN: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
104671818  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
104672038  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
104672131  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
104672288  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104672382  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
104672552  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
104672569  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
104672577  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
104673059  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
104673121  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
104674083  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
104674240  [KO:K07127] [EC:3.5.2.17]
104674427  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
104674609  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
104674850  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
104675006  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
104675129  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
104675162  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104675204  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X2 [KO:K10808] [EC:1.17.4.1]
104675634  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
104675668  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
104675683  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
104676848  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
104676959  NME4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
104677031  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
104677430  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
104677513  [KO:K00365] [EC:1.7.3.3]
104677558  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X4 [KO:K01511] [EC:3.6.1.6]
104677958  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
104678021  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
104678076  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
104678639  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
104678729  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104678868  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
104679268  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
104679293  AMPD3; AMP deaminase 3 isoform X2 [KO:K01490] [EC:3.5.4.6]
104680000  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
104680295  [KO:K00940] [EC:2.7.4.6]
104680296  [KO:K00940] [EC:2.7.4.6]
104680391  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
104680613  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
104680789  [KO:K00940] [EC:2.7.4.6]
104681060  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
104681319  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
104681566  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
104681857  [KO:K06928] [EC:3.6.1.15]
104681940  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
104682433  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
104682459  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6 [KO:K13293] [EC:3.1.4.53]
115892773  [KO:K06928] [EC:3.6.1.15]
115896340  [KO:K00940] [EC:2.7.4.6]
115899091  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
115900420  [KO:K01510] [EC:3.6.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
rro00030  Pentose phosphate pathway
rro00220  Arginine biosynthesis
rro00250  Alanine, aspartate and glutamate metabolism
rro00260  Glycine, serine and threonine metabolism
rro00340  Histidine metabolism
rro00630  Glyoxylate and dicarboxylate metabolism
rro00730  Thiamine metabolism
rro00740  Riboflavin metabolism
rro00790  Folate biosynthesis
KO pathway
ko00230   

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