KEGG   PATHWAY: sek00260
Entry
sek00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Paratyphi A AKU12601
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sek00260  Glycine, serine and threonine metabolism
sek00260

Module
sek_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sek00260]
sek_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sek00260]
sek_M00621  Glycine cleavage system [PATH:sek00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Paratyphi A AKU12601 [GN:sek]
Gene
SSPA3746  lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
SSPA0002  aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SSPA3671  bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SSPA3165  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SSPA0003  homoserine kinase [KO:K00872] [EC:2.7.1.39]
SSPA0004  threonine synthase [KO:K01733] [EC:4.2.3.1]
SSPA1735  L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SSPA0293  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SSPA1596  putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic region [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SSPA3265  putative 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SSPA0352  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SSPA2043  glycerate kinase [KO:K00865] [EC:2.7.1.165]
SSPA2631  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SSPA2909  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
SSPA1847  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
SSPA4080  probable phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]
SSPA3319  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SSPA2732  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SSPA1693  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SSPA4073  putative phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SSPA1249  putative oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SSPA3324  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SSPA3323  threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SSPA2723  glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
SSPA2725  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SSPA0154  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SSPA2724  glycine cleavage system H protein [KO:K02437]
SSPA0251  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
SSPA0977  L-serine deaminase 1 [KO:K01752] [EC:4.3.1.17]
SSPA2640  L-serine dehydratase 2 (L-serine deaminase 2) [KO:K01752] [EC:4.3.1.17]
SSPA2901  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SSPA3489  threonine deaminase [KO:K01754] [EC:4.3.1.19]
SSPA2907  catabolic threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SSPA3411  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
SSPA2685  conserved hypothetical protein [KO:K25316] [EC:5.1.1.10]
SSPA1069  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SSPA1070  tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sek00010  Glycolysis / Gluconeogenesis
sek00020  Citrate cycle (TCA cycle)
sek00230  Purine metabolism
sek00250  Alanine, aspartate and glutamate metabolism
sek00270  Cysteine and methionine metabolism
sek00290  Valine, leucine and isoleucine biosynthesis
sek00300  Lysine biosynthesis
sek00330  Arginine and proline metabolism
sek00460  Cyanoamino acid metabolism
sek00470  D-Amino acid metabolism
sek00564  Glycerophospholipid metabolism
sek00600  Sphingolipid metabolism
sek00620  Pyruvate metabolism
sek00630  Glyoxylate and dicarboxylate metabolism
sek00640  Propanoate metabolism
sek00680  Methane metabolism
sek00860  Porphyrin metabolism
sek00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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