KEGG   PATHWAY: senb00260
Entry
senb00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Bovismorbificans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
senb00260  Glycine, serine and threonine metabolism
senb00260

Module
senb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:senb00260]
senb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:senb00260]
senb_M00621  Glycine cleavage system [PATH:senb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Bovismorbificans [GN:senb]
Gene
BN855_42880  lysC; aspartokinase III, lysine-sensitive [KO:K00928] [EC:2.7.2.4]
BN855_10  thrA; aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BN855_41790  hypothetical protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BN855_36120  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BN855_20  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
BN855_30  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BN855_8780  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BN855_26440  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BN855_10930  putative 2-hydroxyacid dehydrogenase YcdW [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BN855_37280  yiaE; putative 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BN855_25770  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BN855_33270  conserved hypothetical protein STY3429 [KO:K00865] [EC:2.7.1.165]
BN855_5240  glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
BN855_30190  hypothetical protein [KO:K00865] [EC:2.7.1.165]
BN855_7430  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BN855_46580  gpmB; putative phosphoglyceromutase 2 [KO:K15634] [EC:5.4.2.11]
BN855_37990  pmgI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
BN855_31290  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BN855_9170  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BN855_46510  serB2; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BN855_15510  NADP-dependent l-serine/l-allo-threonine dehydrogenase ydfg [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BN855_38040  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BN855_38030  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BN855_31200  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BN855_31220  gcvT; glycine cleavage complex protein T [KO:K00605] [EC:2.1.2.10]
BN855_1640  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BN855_31210  gcvH; glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437]
BN855_27500  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
BN855_33210  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BN855_22860  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BN855_30320  hypothetical protein [KO:K01752] [EC:4.3.1.17]
BN855_18840  hypothetical protein [KO:K01752] [EC:4.3.1.17]
BN855_33250  tdcB; threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
BN855_39840  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
BN855_38940  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BN855_30780  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BN855_17800  trpA; tryptophan synthase, alpha protein [KO:K01695] [EC:4.2.1.20]
BN855_17790  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
senb00010  Glycolysis / Gluconeogenesis
senb00020  Citrate cycle (TCA cycle)
senb00230  Purine metabolism
senb00250  Alanine, aspartate and glutamate metabolism
senb00270  Cysteine and methionine metabolism
senb00290  Valine, leucine and isoleucine biosynthesis
senb00300  Lysine biosynthesis
senb00330  Arginine and proline metabolism
senb00460  Cyanoamino acid metabolism
senb00470  D-Amino acid metabolism
senb00564  Glycerophospholipid metabolism
senb00600  Sphingolipid metabolism
senb00620  Pyruvate metabolism
senb00630  Glyoxylate and dicarboxylate metabolism
senb00640  Propanoate metabolism
senb00680  Methane metabolism
senb00860  Porphyrin metabolism
senb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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