KEGG   PATHWAY: seo00260
Entry
seo00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Typhimurium 14028S
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
seo00260  Glycine, serine and threonine metabolism
seo00260

Module
seo_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:seo00260]
seo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:seo00260]
seo_M00621  Glycine cleavage system [PATH:seo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Typhimurium 14028S [GN:seo]
Gene
STM14_0002  thrA; bifunctional aspartokinase I/homeserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
STM14_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
STM14_0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
STM14_0185  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
STM14_0615  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
STM14_0896  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
STM14_1049  ltaA; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
STM14_1105  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
STM14_1299  ycdW; putative oxidoreductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
STM14_1825  ydfG; 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
STM14_2089  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
STM14_2090  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
STM14_2208  sdaA; L-serine deaminase I/L-threonine deaminase I [KO:K01752] [EC:4.3.1.17]
STM14_2709  [KO:K01752] [EC:4.3.1.17]
STM14_3133  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STM14_3250  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
STM14_3567  [KO:K00865] [EC:2.7.1.165]
STM14_3582  sdaB; L-serine dehydratase/L-threonine deaminase 2 [KO:K01752] [EC:4.3.1.17]
STM14_3640  ygeA; putative racemase [KO:K25316]
STM14_3687  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
STM14_3688  gcvH; glycine cleavage system protein H [KO:K02437]
STM14_3689  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
STM14_3699  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
STM14_3922  tdcG; L-serine deaminase [KO:K01752] [EC:4.3.1.17]
STM14_3926  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STM14_3929  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
STM14_4260  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
STM14_4396  yiaE; 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
STM14_4464  pmgI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
STM14_4469  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
STM14_4470  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
STM14_4591  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
STM14_4702  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STM14_4929  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
STM14_5074  lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
STM14_5499  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
STM14_5506  gpmB; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
C23135  (2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate
C23136  4-Amino-L-allothreonine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
seo00010  Glycolysis / Gluconeogenesis
seo00020  Citrate cycle (TCA cycle)
seo00230  Purine metabolism
seo00250  Alanine, aspartate and glutamate metabolism
seo00270  Cysteine and methionine metabolism
seo00290  Valine, leucine and isoleucine biosynthesis
seo00300  Lysine biosynthesis
seo00330  Arginine and proline metabolism
seo00460  Cyanoamino acid metabolism
seo00470  D-Amino acid metabolism
seo00564  Glycerophospholipid metabolism
seo00600  Sphingolipid metabolism
seo00620  Pyruvate metabolism
seo00630  Glyoxylate and dicarboxylate metabolism
seo00640  Propanoate metabolism
seo00680  Methane metabolism
seo00860  Porphyrin metabolism
seo00920  Sulfur metabolism
KO pathway
ko00260   

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