KEGG   PATHWAY: sglc00260
Entry
sglc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Sphingomonas glaciei
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sglc00260  Glycine, serine and threonine metabolism
sglc00260

Module
sglc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sglc00260]
sglc_M00621  Glycine cleavage system [PATH:sglc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sphingomonas glaciei [GN:sglc]
Gene
M1K48_11990  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M1K48_03585  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M1K48_01530  homoserine kinase [KO:K00872] [EC:2.7.1.39]
M1K48_01525  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
M1K48_05715  threonine synthase [KO:K01733] [EC:4.2.3.1]
M1K48_11575  beta-eliminating lyase-related protein [KO:K01620] [EC:4.1.2.48]
M1K48_14210  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M1K48_09310  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
M1K48_12390  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M1K48_12395  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
M1K48_04300  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
M1K48_13760  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
M1K48_14225  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
M1K48_14085  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
M1K48_14090  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
M1K48_14070  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
M1K48_12915  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M1K48_13435  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M1K48_14075  gcvH; glycine cleavage system protein GcvH [KO:K02437]
M1K48_03030  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
M1K48_02575  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
M1K48_07295  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
M1K48_03385  amino acid racemase [KO:K25316] [EC:5.1.1.10]
M1K48_08895  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
M1K48_08900  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sglc00010  Glycolysis / Gluconeogenesis
sglc00020  Citrate cycle (TCA cycle)
sglc00230  Purine metabolism
sglc00250  Alanine, aspartate and glutamate metabolism
sglc00270  Cysteine and methionine metabolism
sglc00290  Valine, leucine and isoleucine biosynthesis
sglc00300  Lysine biosynthesis
sglc00330  Arginine and proline metabolism
sglc00460  Cyanoamino acid metabolism
sglc00470  D-Amino acid metabolism
sglc00564  Glycerophospholipid metabolism
sglc00620  Pyruvate metabolism
sglc00630  Glyoxylate and dicarboxylate metabolism
sglc00640  Propanoate metabolism
sglc00680  Methane metabolism
sglc00860  Porphyrin metabolism
sglc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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