KEGG PATHWAY: sod00260

PATHWAY: sod00260

Entry

sod00260                    Pathway

Name

Glycine, serine and threonine metabolism - Sodalis praecaptivus

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

sod00260

Glycine, serine and threonine metabolism

Module

sod_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sod00260]

sod_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:sod00260]

sod_M00621

Glycine cleavage system [PATH:sod00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Sodalis praecaptivus [GN:sod]

Gene

Sant_0094

[KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

Sant_0281

ilvA; Threonine dehydratase [KO:K01754] [EC:4.3.1.19]

Sant_0349

asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

Sant_0771

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

Sant_0779

gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]

Sant_0780

gvcH; Glycine cleavage system H protein [KO:K02437]

Sant_0781

gcvP; Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

Sant_0935

pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]

Sant_1118

glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Sant_1269

[KO:K25316]

Sant_1753

[KO:K00058] [EC:1.1.1.95 1.1.1.399]

Sant_1786

sdaA; L-serine deamindase 1 [KO:K01752] [EC:4.3.1.17]

Sant_1853

trpA; Tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]

Sant_1854

trpB; Tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

Sant_1955

[KO:K00865] [EC:2.7.1.165]

Sant_1995

[KO:K16066] [EC:1.1.1.381 1.1.1.-]

Sant_2202

[KO:K12972] [EC:1.1.1.79 1.1.1.81]

Sant_2216

[KO:K00301] [EC:1.5.3.1]

Sant_2634

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Sant_2656

ltaE; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

Sant_2712

[KO:K01834] [EC:5.4.2.11]

Sant_2749

gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

Sant_3267

garK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]

Sant_3326

lpdA; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

Sant_3408

thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]

Sant_3409

thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]

Sant_3410

thrA; Bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]

Sant_3415

gpmB; Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]

Sant_3422

serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

Sant_3834

[KO:K01754] [EC:4.3.1.19]

Sant_3884

lysC; Aspartate kinase III [KO:K00928] [EC:2.7.2.4]

Sant_3961

metL; Bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721