KEGG   PATHWAY: spad00280
Entry
spad00280                   Pathway                                
Name
Valine, leucine and isoleucine degradation - Streptomyces paludis
Class
Metabolism; Amino acid metabolism
Pathway map
spad00280  Valine, leucine and isoleucine degradation
spad00280

Module
spad_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:spad00280]
spad_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:spad00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Streptomyces paludis [GN:spad]
Gene
DVK44_03530  aminodeoxychorismate lyase [KO:K00826] [EC:2.6.1.42]
DVK44_25610  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
DVK44_14735  Glu/Leu/Phe/Val dehydrogenase [KO:K00271] [EC:1.4.1.23]
DVK44_16095  pdhA; pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha [KO:K00166] [EC:1.2.4.4]
DVK44_16010  pdhA; pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha [KO:K00166] [EC:1.2.4.4]
DVK44_16100  alpha-ketoacid dehydrogenase subunit beta [KO:K00167] [EC:1.2.4.4]
DVK44_16015  alpha-ketoacid dehydrogenase subunit beta [KO:K00167] [EC:1.2.4.4]
DVK44_31305  2-oxoisovalerate dehydrogenase [KO:K11381] [EC:1.2.4.4]
DVK44_16105  2-oxo acid dehydrogenase subunit E2 [KO:K09699] [EC:2.3.1.168]
DVK44_16020  2-oxo acid dehydrogenase subunit E2 [KO:K09699] [EC:2.3.1.168]
DVK44_33135  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DVK44_06845  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DVK44_04445  acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
DVK44_31300  acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.8.5]
DVK44_10020  acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.8.5]
DVK44_25150  enoyl-CoA hydratase/isomerase family protein [KO:K01692] [EC:4.2.1.17]
DVK44_30715  3-hydroxyacyl-CoA dehydrogenase [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
DVK44_28395  acetyl-CoA C-acyltransferase [KO:K00632] [EC:2.3.1.16]
DVK44_22315  biotin/lipoyl-binding protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
DVK44_22350  acyl-CoA carboxylase subunit beta [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
DVK44_22345  acyl-CoA carboxylase subunit epsilon [KO:K27095]
DVK44_24650  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
DVK44_02350  methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
DVK44_02355  methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
DVK44_31845  NAD(P)-dependent oxidoreductase [KO:K00020] [EC:1.1.1.31]
DVK44_08000  NAD(P)-dependent oxidoreductase [KO:K00020] [EC:1.1.1.31]
DVK44_09845  mmsA; methylmalonate-semialdehyde dehydrogenase (CoA acylating) [KO:K00140] [EC:1.2.1.18 1.2.1.27]
DVK44_28065  mmsA; methylmalonate-semialdehyde dehydrogenase (CoA acylating) [KO:K00140] [EC:1.2.1.18 1.2.1.27]
DVK44_13440  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
DVK44_22240  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
DVK44_34985  acyl-CoA synthetase [KO:K18661] [EC:6.2.1.76 6.2.1.-]
DVK44_26150  gabT; 4-aminobutyrate--2-oxoglutarate transaminase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
DVK44_10010  ATP-grasp domain-containing protein [KO:K01968] [EC:6.4.1.4]
DVK44_10005  methylcrotonoyl-CoA carboxylase [KO:K01969] [EC:6.4.1.4]
DVK44_28950  enoyl-CoA hydratase/isomerase family protein [KO:K13766] [EC:4.2.1.18]
DVK44_10015  hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
DVK44_35350  CoA transferase subunit A [KO:K01028] [EC:2.8.3.5]
DVK44_35345  CoA transferase subunit B [KO:K01029] [EC:2.8.3.5]
DVK44_02925  acetoacetate--CoA ligase [KO:K01907] [EC:6.2.1.16]
DVK44_30710  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
DVK44_21245  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
DVK44_24655  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
DVK44_34370  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
spad00020  Citrate cycle (TCA cycle)
spad00240  Pyrimidine metabolism
spad00290  Valine, leucine and isoleucine biosynthesis
spad00640  Propanoate metabolism
spad00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   
LinkDB

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