KEGG   PATHWAY: spen00480
Entry
spen00480                   Pathway                                
Name
Glutathione metabolism - Solanum pennellii
Class
Metabolism; Metabolism of other amino acids
Pathway map
spen00480  Glutathione metabolism
spen00480

Module
spen_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:spen00480]
Other DBs
GO: 0006749
Organism
Solanum pennellii [GN:spen]
Gene
107007403  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107019015  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107026636  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
107005374  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
107003194  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
107031363  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
107028588  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107008034  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107005617  LOW QUALITY PROTEIN: leucine aminopeptidase 1, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
107005629  leucine aminopeptidase 1, chloroplastic [KO:K01255] [EC:3.4.11.1]
107007191  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
107028384  puromycin-sensitive aminopeptidase isoform X2 [KO:K01256] [EC:3.4.11.2]
107013143  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107013156  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107011626  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107025523  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
107031786  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031787  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031791  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031792  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031793  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031794  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107013630  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107006427  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
107006428  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
107006432  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
107023454  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107028498  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107028500  glutathione S-transferase T1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
107001994  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107030621  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107030623  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
107005591  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107006915  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107030021  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107025609  LOW QUALITY PROTEIN: probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
107032464  glutathione transferase GST 23-like isoform X2 [KO:K00799] [EC:2.5.1.18]
107019961  glutathione S-transferase U17-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107024301  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107026068  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107026069  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107014106  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107029376  glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
107030723  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107005278  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107006652  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
107008460  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107007458  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
107018308  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107019535  LOW QUALITY PROTEIN: glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107024338  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107032377  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107030761  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107030773  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107030794  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107030829  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107001778  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107006720  glutathione S-transferase U19-like [KO:K00799] [EC:2.5.1.18]
107006732  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107010531  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107010995  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
107008877  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107029498  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107006808  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107023720  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107025904  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
107025905  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
107029933  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031327  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031328  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031330  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031332  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107031333  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
107002283  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
114073942  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
114075997  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
107004866  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107020618  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107031132  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107031213  glutathione reductase, chloroplastic isoform X1 [KO:K00383] [EC:1.8.1.7]
107011997  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107004420  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107007760  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107018396  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107020560  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107007274  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107025976  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107011708  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107020595  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107025712  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107021052  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
107028836  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107028087  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107028642  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
107005688  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
107013901  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
107013578  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107018207  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
107014103  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107013171  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107013852  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107013854  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107013893  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107020620  spermidine synthase [KO:K00797] [EC:2.5.1.16]
107018265  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
107022355  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
107015092  spermine synthase [KO:K00797] [EC:2.5.1.16]
107029646  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
107029648  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
107023881  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
107023536  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107023623  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
107008867  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
107029071  putative L-ascorbate peroxidase 6 isoform X2 [KO:K00434] [EC:1.11.1.11]
107005028  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
107007774  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107009391  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107017905  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
107015598  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107008659  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
107011918  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
spen00220  Arginine biosynthesis
spen00250  Alanine, aspartate and glutamate metabolism
spen00270  Cysteine and methionine metabolism
spen00430  Taurine and hypotaurine metabolism
spen00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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