KEGG   PATHWAY: sply00760
Entry
sply00760                   Pathway                                
Name
Nicotinate and nicotinamide metabolism - Serratia inhibens
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
sply00760  Nicotinate and nicotinamide metabolism
sply00760

Module
sply_M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:sply00760]
sply_M00622  Nicotinate degradation, nicotinate => fumarate [PATH:sply00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Serratia inhibens [GN:sply]
Gene
Q5A_019395  nadB; L-aspartate oxidase [KO:K00278] [EC:1.4.3.16]
Q5A_020975  nadX; L-aspartate dehydrogenase [KO:K06989] [EC:1.4.1.21]
Q5A_006470  nadA; Quinolinate synthase A [KO:K03517] [EC:2.5.1.72]
Q5A_003390  nadC; Nicotinate-nucleotide pyrophosphorylase [carboxylating] [KO:K00767] [EC:2.4.2.19]
Q5A_008605  pncB; Nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
Q5A_022185  xapA; Purine nucleoside phosphorylase 2 [KO:K03783] [EC:2.4.2.1]
Q5A_002830  deoD; Purine nucleoside phosphorylase DeoD-type [KO:K03784] [EC:2.4.2.1]
Q5A_002855  nadR; Trifunctional NAD biosynthesis/regulator protein NadR [KO:K06211] [EC:2.7.7.1 2.7.1.22]
Q5A_005320  mggB; Mannosylglucosyl-3-phosphoglycerate phosphatase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
Q5A_003630  surE; 5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
Q5A_006140  nagD; Ribonucleotide monophosphatase NagD [KO:K02566] [EC:3.1.3.5]
Q5A_006010  nadD; Nicotinate-nucleotide adenylyltransferase [KO:K00969] [EC:2.7.7.18]
Q5A_003495  mazG; Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
Q5A_001365  nudC; NADH pyrophosphatase [KO:K03426] [EC:3.6.1.22]
Q5A_019260  nadE; Glutamine-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]
Q5A_003685  pncC; Nicotinamide-nucleotide amidohydrolase PncC [KO:K03743] [EC:3.5.1.42]
Q5A_014215  rutB_2; Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB [KO:K08281] [EC:3.5.1.19 3.5.1.-]
Q5A_010060  cobB; NAD-dependent protein deacylase [KO:K12410] [EC:2.3.1.286 2.3.1.313]
Q5A_019435  nadK; NAD kinase [KO:K00858] [EC:2.7.1.23]
Q5A_024790  sthA; Soluble pyridine nucleotide transhydrogenase [KO:K00322] [EC:1.6.1.1]
Q5A_013535  pntA; NAD(P) transhydrogenase subunit alpha [KO:K00324] [EC:7.1.1.1]
Q5A_013530  pntB; NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:7.1.1.1]
Q5A_011880  nicA; Nicotinate dehydrogenase subunit A [KO:K18029] [EC:1.17.2.1]
Q5A_011885  nicB; Nicotinate dehydrogenase subunit B [KO:K18030] [EC:1.17.2.1]
Q5A_011865  nicC; 6-hydroxynicotinate 3-monooxygenase [KO:K14974] [EC:1.14.13.114]
Q5A_011870  nicX; 2,5-dihydroxypyridine 5,6-dioxygenase [KO:K18028] [EC:1.13.11.9]
Q5A_011860  nicD; N-formylmaleamate deformylase [KO:K15357] [EC:3.5.1.106]
Q5A_011850  nicF; Maleamate amidohydrolase [KO:K13995] [EC:3.5.1.107]
Q5A_011855  maiA; Maleate isomerase [KO:K01799] [EC:5.2.1.1]
Q5A_006850  gabD1; Succinate-semialdehyde dehydrogenase [NADP(+)] 1 [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
Q5A_013365  araE; Alpha-ketoglutaric semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
Q5A_016100  davD; Glutarate-semialdehyde dehydrogenase DavD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
Q5A_022445  gabD; Succinate-semialdehyde dehydrogenase [NADP(+)] GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
sply00020  Citrate cycle (TCA cycle)
sply00250  Alanine, aspartate and glutamate metabolism
sply00380  Tryptophan metabolism
sply00620  Pyruvate metabolism
sply00660  C5-Branched dibasic acid metabolism
KO pathway
ko00760   
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