KEGG   PATHWAY: suv00020
Entry
suv00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Staphylococcus aureus subsp. aureus VC40
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
suv00020  Citrate cycle (TCA cycle)
suv00020

Module
suv_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:suv00020]
suv_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:suv00020]
suv_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:suv00020]
suv_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:suv00020]
suv_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:suv00020]
Other DBs
GO: 0006099
Organism
Staphylococcus aureus subsp. aureus VC40 [GN:suv]
Gene
SAVC_07680  citrate synthase [KO:K01659] [EC:2.3.3.5]
SAVC_05995  aconitate hydratase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
SAVC_07675  isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
SAVC_06315  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
SAVC_06310  dihydrolipoamide succinyltransferase [KO:K00658] [EC:2.3.1.61]
SAVC_04640  dihydrolipoamide dehydrogenase PdhD [KO:K00382] [EC:1.8.1.4]
SAVC_06840  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVC_05610  pyruvate ferredoxin oxidoreductase, alpha subunit [KO:K00174] [EC:1.2.7.3 1.2.7.11]
SAVC_05615  2-oxoglutarate ferredoxin oxidoreductase subunit beta [KO:K00175] [EC:1.2.7.3 1.2.7.11]
SAVC_05395  succinyl-CoA synthetase subunit alpha [KO:K01902] [EC:6.2.1.5]
SAVC_05390  sucC; succinyl-CoA synthetase subunit beta [KO:K01903] [EC:6.2.1.5]
SAVC_04905  sdhA; succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
SAVC_04910  sdhB; succinate dehydrogenase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
SAVC_04900  succinate dehydrogenase, cytochrome b558 subunit [KO:K00241]
SAVC_08500  fumC; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
SAVC_11900  malate:quinone oxidoreductase [KO:K00116] [EC:1.1.5.4]
SAVC_10695  malate:quinone oxidoreductase [KO:K00116] [EC:1.1.5.4]
SAVC_04735  pyruvate carboxylase PycA [KO:K01958] [EC:6.4.1.1]
SAVC_08165  phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
SAVC_04625  pyruvate dehydrogenase E1 component alpha subunit [KO:K00161] [EC:1.2.4.1]
SAVC_04630  pyruvate dehydrogenase E1 component beta subunit [KO:K00162] [EC:1.2.4.1]
SAVC_04635  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
suv00010  Glycolysis / Gluconeogenesis
suv00053  Ascorbate and aldarate metabolism
suv00061  Fatty acid biosynthesis
suv00071  Fatty acid degradation
suv00190  Oxidative phosphorylation
suv00220  Arginine biosynthesis
suv00250  Alanine, aspartate and glutamate metabolism
suv00280  Valine, leucine and isoleucine degradation
suv00350  Tyrosine metabolism
suv00470  D-Amino acid metabolism
suv00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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