KEGG   PATHWAY: tsp04010
Entry
tsp04010                    Pathway                                
Name
MAPK signaling pathway - Trichinella spiralis
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tsp04010  MAPK signaling pathway
tsp04010

Other DBs
GO: 0000165
Organism
Trichinella spiralis [GN:tsp]
Gene
Tsp_07724  transporter, cation channel family [KO:K04851]
Tsp_06861  voltage gated calcium channel IQ domain protein [KO:K04851]
Tsp_10785  voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
Tsp_03463  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
Tsp_00969  cAMP-dependent protein kinase catalytic subunit [KO:K04345] [EC:2.7.11.11]
Tsp_00967  protein kinase A catalytic subunit [KO:K04345] [EC:2.7.11.11]
Tsp_00479  guanine nucleotide-binding protein alpha-12 subunit [KO:K04346]
Tsp_08323  serine/threonine-protein phosphatase 2B catalytic subunit 2 [KO:K04348] [EC:3.1.3.16]
Tsp_02876  calcineurin B subunit [KO:K06268]
Tsp_12574  putative RasGEF domain protein [KO:K08018]
Tsp_05894  putative RasGEF domain protein [KO:K08018]
Tsp_12677  putative Ras association domain protein [KO:K08018]
Tsp_02666  GTPase KRas [KO:K04353]
Tsp_09844  fibroblast growth factor 18 [KO:K04358]
Tsp_11318  fibroblast growth factor 20 [KO:K04358]
Tsp_10902  insulin/IGF/Relaxin family protein [KO:K04526]
Tsp_00617  putative fibroblast growth factor receptor 2 [KO:K04362] [EC:2.7.10.1]
Tsp_05323  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
Tsp_12077  putative receptor L domain protein [KO:K05087] [EC:2.7.10.1]
Tsp_00087  putative kinase domain protein [KO:K05096] [EC:2.7.10.1]
Tsp_07994  Sex muscle abnormal protein 5 [KO:K04364]
Tsp_08277  protein son of sevenless [KO:K03099]
Tsp_07908  Ras protein let-60 [KO:K07827]
Tsp_05804  b-Raf proto-oncogene serine/threonine-protein kinase [KO:K04365] [EC:2.7.11.1]
Tsp_10801  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
Tsp_01601  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Tsp_09595  MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
Tsp_10306  hypothetical protein [KO:K04373] [EC:2.7.11.1]
Tsp_03174  serum response factor [KO:K04378]
Tsp_05588  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
Tsp_03569  putative protein kinase domain protein [KO:K04674] [EC:2.7.11.30]
Tsp_04387  cell division control protein 42-like protein [KO:K04392]
Tsp_03972  Cdc42-like protein [KO:K04392]
Tsp_04183  protein SYM1 [KO:K04405]
Tsp_07847  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
Tsp_03757  serine/threonine-protein kinase 4 [KO:K04412]
Tsp_07016  mitogen-activated protein kinase kinase kinase 11 [KO:K04417] [EC:2.7.11.25]
Tsp_09483  mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
Tsp_00085  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
Tsp_02206  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
Tsp_05725  C-jun-amino- kinase-interacting protein [KO:K04434]
Tsp_12751  putative filamin/ABP280 repeat-containing domain protein [KO:K04437]
Tsp_02523  putative filamin/ABP280 repeat-containing domain protein [KO:K04437]
Tsp_02524  putative filamin/ABP280 repeat-containing domain protein [KO:K04437]
Tsp_12104  putative filamin/ABP280 repeat-containing domain protein [KO:K04437]
Tsp_06038  adapter molecule Crk [KO:K04438]
Tsp_04009  beta-arrestin-1 [KO:K04439]
Tsp_05770  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
Tsp_03128  mitogen-activated protein kinase 14a [KO:K04441] [EC:2.7.11.24]
Tsp_10399  MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
Tsp_10984  MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
Tsp_05339  transcription factor AP-1 [KO:K04448]
Tsp_05337  transcription factor AP-1 [KO:K04448]
Tsp_05266  putative cellular tumor antigen p53 [KO:K04451]
Tsp_02503  RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
Tsp_11906  dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
Tsp_02993  dual specificity protein phosphatase 7 (Dual specificity protein phosphatase PYST2) [KO:K04459] [EC:3.1.3.16 3.1.3.48]
Tsp_12613  dual specificity protein phosphatase 6 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
Tsp_03046  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
Tsp_05990  protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
Tsp_06317  heat shockprotein A [KO:K03283]
Tsp_10471  heat shock cognate protein [KO:K03283]
Tsp_06402  nuclear receptor subfamily 4 group A member 1 [KO:K04465]
Tsp_01235  extracellular signal-regulated kinase 1 [KO:K04468] [EC:2.7.11.24]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tsp04070  Phosphatidylinositol signaling system
tsp04310  Wnt signaling pathway
KO pathway
ko04010   
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