KEGG   PATHWAY: ype00260
Entry
ype00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yersinia pestis CO92 (biovar Orientalis)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ype00260  Glycine, serine and threonine metabolism
ype00260

Module
ype_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ype00260]
ype_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ype00260]
ype_M00555  Betaine biosynthesis, choline => betaine [PATH:ype00260]
ype_M00621  Glycine cleavage system [PATH:ype00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yersinia pestis CO92 (biovar Orientalis) [GN:ype]
Gene
YPO3719  apk; lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
YPO0459  thrA; bifunctional aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
YPO0116  metL; bifunctional aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
YPO3949  asd; aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
YPO0460  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
YPO0461  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
YPO1357  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
YPO2907  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
YPO4078  putative D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
YPO3980  glxK; putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
YPO1133  gpm; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
YPO0455  gpmB; putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
YPO0064  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
YPO1288  putative D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YPO0914  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YPO1389  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
YPO0442  b4388; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
YPO0059  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
YPO0060  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
YPO0905  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
YPO0907  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
YPO3917  putative pyridine nucleotide-disulphide oxidoreductase [KO:K00382] [EC:1.8.1.4]
YPO3417  lpd; dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase complex [KO:K00382] [EC:1.8.1.4]
YPO0906  gcsH; glycine cleavage system H protein [KO:K02437]
YPO3273  pss; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
YPO1165  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
YPO1166  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
YPO1771  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
YPO3896  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
YPO4089  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
YPO2758  putative aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
YPO1687  putative alanine racemase [KO:K25317] [EC:5.1.1.10]
YPO2203  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
YPO2204  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
YPO1529  putative decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ype00010  Glycolysis / Gluconeogenesis
ype00020  Citrate cycle (TCA cycle)
ype00230  Purine metabolism
ype00250  Alanine, aspartate and glutamate metabolism
ype00270  Cysteine and methionine metabolism
ype00290  Valine, leucine and isoleucine biosynthesis
ype00300  Lysine biosynthesis
ype00330  Arginine and proline metabolism
ype00460  Cyanoamino acid metabolism
ype00470  D-Amino acid metabolism
ype00564  Glycerophospholipid metabolism
ype00600  Sphingolipid metabolism
ype00620  Pyruvate metabolism
ype00630  Glyoxylate and dicarboxylate metabolism
ype00640  Propanoate metabolism
ype00680  Methane metabolism
ype00860  Porphyrin metabolism
ype00920  Sulfur metabolism
KO pathway
ko00260   
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