KEGG   PATHWAY: zof00020
Entry
zof00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Zingiber officinale (ginger)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
zof00020  Citrate cycle (TCA cycle)
zof00020

Module
zof_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:zof00020]
zof_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:zof00020]
zof_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:zof00020]
Other DBs
GO: 0006099
Organism
Zingiber officinale (ginger) [GN:zof]
Gene
122043183  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
122019869  citrate synthase 3, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
122031731  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
122047708  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
122034324  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
122023624  citrate synthase 3, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
121988965  ATP-citrate synthase beta chain protein 1-like [KO:K01648] [EC:2.3.3.8]
121991692  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
121991693  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
122045446  ATP-citrate synthase alpha chain protein 3 [KO:K01648] [EC:2.3.3.8]
121991981  ATP-citrate synthase alpha chain protein 3-like [KO:K01648] [EC:2.3.3.8]
121980350  ATP-citrate synthase alpha chain protein 2-like isoform X1 [KO:K01648] [EC:2.3.3.8]
121995581  ATP-citrate synthase beta chain protein 1-like [KO:K01648] [EC:2.3.3.8]
121995895  ATP-citrate synthase alpha chain protein 2-like isoform X1 [KO:K01648] [EC:2.3.3.8]
122037982  ATP-citrate synthase alpha chain protein 3 [KO:K01648] [EC:2.3.3.8]
122038774  ATP-citrate synthase beta chain protein 1-like isoform X1 [KO:K01648] [EC:2.3.3.8]
122040939  ATP-citrate synthase alpha chain protein 2-like [KO:K01648] [EC:2.3.3.8]
121976801  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
121980553  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
121967612  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
122052850  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
121970806  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
121984460  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
122016472  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
122045248  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
121991882  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
121980045  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
121993147  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
121995788  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
121997111  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122020347  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122051877  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
121984118  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
122040707  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122041231  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122045728  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
121992486  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
121996434  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
122051063  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122020817  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122020964  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122021256  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122055646  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122024507  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
122024723  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122024881  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
122017623  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
122006947  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
122009519  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
121981478  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
121985356  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
122002704  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
122024795  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
121975276  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
121976025  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
121970191  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
121971628  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
122031834  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
122009962  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
121982037  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
122034484  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
122015401  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
121985907  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
122005545  succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
122014606  succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
122001253  succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
122055891  succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
122024659  succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
122007913  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial-like [KO:K01900] [EC:6.2.1.4 6.2.1.5]
121969959  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial-like [KO:K01900] [EC:6.2.1.4 6.2.1.5]
122015800  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
122056249  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
121989606  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
122051726  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
121998546  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
122027704  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122029417  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122032672  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122035042  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122036045  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122053323  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
122017524  succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236]
122010145  succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236]
121981825  succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236]
121981828  succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236]
121985673  succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236]
121985676  succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236]
122045500  fumarate hydratase 1, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
122040995  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
122042530  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
122045438  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
121992038  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
122047045  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
121995957  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
122040932  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
122042397  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
121975345  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
121992668  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
122046908  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
121993162  malate dehydrogenase, glyoxysomal-like isoform X1 [KO:K00026] [EC:1.1.1.37]
121996628  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
122010255  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
122034122  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
121997126  malate dehydrogenase, glyoxysomal-like isoform X1 [KO:K00026] [EC:1.1.1.37]
122020348  malate dehydrogenase, glyoxysomal isoform X1 [KO:K00026] [EC:1.1.1.37]
122021156  malate dehydrogenase, mitochondrial-like isoform X1 [KO:K00026] [EC:1.1.1.37]
122022755  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
122023696  malate dehydrogenase, glyoxysomal-like isoform X1 [KO:K00026] [EC:1.1.1.37]
122016486  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
122024987  malate dehydrogenase, mitochondrial-like isoform X1 [KO:K00026] [EC:1.1.1.37]
121974903  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
122019250  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
121976972  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
122048167  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
122051045  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
121968489  phosphoenolpyruvate carboxykinase (ATP) 1-like isoform X1 [KO:K01610] [EC:4.1.1.49]
121969776  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
121999283  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
121999556  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
122052430  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
122054806  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
122054875  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
121971950  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
122055629  phosphoenolpyruvate carboxykinase (ATP) 1-like [KO:K01610] [EC:4.1.1.49]
121991890  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
121995797  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
122032193  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
121980925  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like isoform X1 [KO:K00161] [EC:1.2.4.1]
122010131  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
121981816  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
122034686  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
121976558  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
121967251  pyruvate dehydrogenase E1 component subunit beta-like [KO:K00162] [EC:1.2.4.1]
122051360  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
122052464  pyruvate dehydrogenase E1 component subunit beta-like [KO:K00162] [EC:1.2.4.1]
121971115  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
122055731  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
122017715  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
122004961  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
122027536  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
122006968  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
122029874  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
122049388  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
122020248  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
122001917  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
122024121  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
122002722  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
zof00010  Glycolysis / Gluconeogenesis
zof00053  Ascorbate and aldarate metabolism
zof00061  Fatty acid biosynthesis
zof00062  Fatty acid elongation
zof00071  Fatty acid degradation
zof00190  Oxidative phosphorylation
zof00220  Arginine biosynthesis
zof00250  Alanine, aspartate and glutamate metabolism
zof00280  Valine, leucine and isoleucine degradation
zof00350  Tyrosine metabolism
zof00470  D-Amino acid metabolism
zof00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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