PATHWAY: zof00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Zingiber officinale (ginger)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
zof_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:zof00020 ]
Other DBs
Organism
Zingiber officinale (ginger) [GN:
zof ]
Gene
121992486 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
121996434 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
121975276 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
121976025 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
121970191 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
121971628 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
121989606 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
122051726 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
121998546 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
122027704 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122029417 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122032672 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122035042 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122036045 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122053323 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
122017524 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
122010145 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
121981825 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
121981828 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
121985673 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
121985676 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
121980925 pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
122017715 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
122004961 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
122027536 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
122006968 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
122029874 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
122049388 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
122020248 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
122001917 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
122024121 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
122002722 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
zof00053 Ascorbate and aldarate metabolism
zof00250 Alanine, aspartate and glutamate metabolism
zof00280 Valine, leucine and isoleucine degradation
zof00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs